Multi-scale optoacoustic molecular imaging of brain diseases.


Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
12 2021
Historique:
received: 07 12 2020
accepted: 17 01 2021
pubmed: 18 2 2021
medline: 12 11 2021
entrez: 17 2 2021
Statut: ppublish

Résumé

The ability to non-invasively visualize endogenous chromophores and exogenous probes and sensors across the entire rodent brain with the high spatial and temporal resolution has empowered optoacoustic imaging modalities with unprecedented capacities for interrogating the brain under physiological and diseased conditions. This has rapidly transformed optoacoustic microscopy (OAM) and multi-spectral optoacoustic tomography (MSOT) into emerging research tools to study animal models of brain diseases. In this review, we describe the principles of optoacoustic imaging and showcase recent technical advances that enable high-resolution real-time brain observations in preclinical models. In addition, advanced molecular probe designs allow for efficient visualization of pathophysiological processes playing a central role in a variety of neurodegenerative diseases, brain tumors, and stroke. We describe outstanding challenges in optoacoustic imaging methodologies and propose a future outlook.

Identifiants

pubmed: 33594473
doi: 10.1007/s00259-021-05207-4
pii: 10.1007/s00259-021-05207-4
pmc: PMC8566397
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

4152-4170

Subventions

Organisme : NINDS NIH HHS
ID : UF1 NS107680
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Daniel Razansky (D)

Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Wolfgang-Pauli-Strasse 27, HIT E42.1, 8093, Zurich, Switzerland.
Zurich Neuroscience Center (ZNZ), Zurich, Switzerland.
Faculty of Medicine and Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

Jan Klohs (J)

Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Wolfgang-Pauli-Strasse 27, HIT E42.1, 8093, Zurich, Switzerland.
Zurich Neuroscience Center (ZNZ), Zurich, Switzerland.

Ruiqing Ni (R)

Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Wolfgang-Pauli-Strasse 27, HIT E42.1, 8093, Zurich, Switzerland. ruiqing.ni@uzh.ch.
Zurich Neuroscience Center (ZNZ), Zurich, Switzerland. ruiqing.ni@uzh.ch.
Institute for Regenerative Medicine, Uiversity of Zurich, Zurich, Switzerland. ruiqing.ni@uzh.ch.

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