Histological categorisation of the desmoplastic reaction is a predictor of patient prognosis in oesophageal squamous cell carcinoma.
Adult
Aged
Aged, 80 and over
Cancer-Associated Fibroblasts
/ pathology
Esophageal Neoplasms
/ diagnosis
Esophageal Squamous Cell Carcinoma
/ diagnosis
Female
Fibrosis
/ classification
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prognosis
Retrospective Studies
Survival Analysis
cancer stroma
cancer-associated fibroblasts
desmoplastic reaction
oesophageal cancer
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
12
02
2021
received:
28
08
2020
accepted:
14
02
2021
pubmed:
18
2
2021
medline:
8
2
2022
entrez:
17
2
2021
Statut:
ppublish
Résumé
Histological categorisation of the desmoplastic reaction (DR) is an independent prognostic factor in colorectal cancer. However, it is unknown whether DR categorisation is predictive of oesophageal squamous cell carcinoma (OSCC) outcomes. This study aimed to evaluate the prognostic value of DR categorisation in OSCC patients. Data were collected from 118 patients with OSCC who underwent a curative oesophagectomy with T2 or deeper wall invasion. The DR in each tumour was classified as mature, intermediate or immature based on the presence or absence of keloid-like collagen and myxoid stroma. We identified 49 mature DR tumours, 41 intermediate DR tumours and 28 immature DR tumours. The 5-year overall survival (OS) rate was highest in the mature DR group (42.8%), followed by the intermediate DR group (25.0%) and the immature DR group (19.9%) (P = 0.022, log-rank test; P = 0.006, log-rank trend test). The 5-year disease-specific survival (DSS) rate was also highest in the mature DR group (48.5%), followed by the intermediate DR group (30.8%) and the immature DR group (26.8%) (P = 0.031, log-rank test; P = 0.010, log-rank trend test, respectively). Multivariate analysis revealed that an immature DR was an independent poor prognostic factor of OS and DSS (P = 0.002 and P = 0.004). DR categorisation of OSCC stroma following oesophagectomy is a useful diagnostic tool and an independent prognostic marker.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-226Informations de copyright
© 2021 John Wiley & Sons Ltd.
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