Severe ocular and adnexal complications in dengue hemorrhagic fever: A report of 29 eyes.
Dengue
necrosis
panophthalmitis
phthisis bulbi
scleral melt
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
entrez:
17
2
2021
pubmed:
18
2
2021
medline:
28
5
2021
Statut:
ppublish
Résumé
To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was lost. Twenty-nine eyes of 23 patients were included. Bilateral ocular involvement was seen in 6 (26%) patients. The mean age was 37.62 ± 18.68 years (range: 14 to 81 years). Coexistent diabetes mellitus and enteric fever were present in three patients. History of blood transfusion was present in nine (40%) and thrombocytopenia in eight (35%) patients at the time of presentation with ocular complaints. Presenting features included endophthalmitis in 11 (38%), panophthalmitis in 10 (35%), orbital cellulitis with panophthalmitis in four (14%), isolated corneal or scleral melt in three (10%), and orbital hemorrhage with panophthalmitis in one (3%) patient. Globe salvage was achieved in 21/29 eyes (72.4%), vision salvage in 6/29 eyes (20.68%), and improvement in visual acuity was noted in 5/29 eyes (17.24%). Logistic regression analysis revealed no significant effect of any clinical-microbiological factors on globe salvage, vision salvage, and visual improvement. However, visual improvement and globe salvage were possible in eyes that underwent early endoscopic vitrectomy. Dengue fever can present with sight-threatening ocular and adnexal inflammation resulting in endophthalmitis and panophthalmitis, orbital cellulitis, corneal and scleral melt, and orbital hemorrhage. Early vitrectomy may improve vision and globe salvage in cases with significant vitritis.
Identifiants
pubmed: 33595487
pii: IndianJOphthalmol_2021_69_3_617_309370
doi: 10.4103/ijo.IJO_1588_20
pmc: PMC7942086
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
617-622Déclaration de conflit d'intérêts
None
Références
Indian J Ophthalmol. 2018 Jul;66(7):1017-1019
pubmed: 29941760
Emerg Infect Dis. 2005 May;11(5):770-2
pubmed: 15890137
Eye (Lond). 2009 Apr;23(4):873-6
pubmed: 18464800
Am J Trop Med Hyg. 2018 Oct;99(4):1053-1054
pubmed: 30062992
Emerg Microbes Infect. 2017 Aug 9;6(8):e70
pubmed: 28790459
Indian J Ophthalmol. 2019 Oct;67(10):1775-1777
pubmed: 31546563
PLoS Negl Trop Dis. 2018 Jul 16;12(7):e0006618
pubmed: 30011275
Ophthalmology. 2004 Nov;111(11):2057-64
pubmed: 15522372
J Family Med Prim Care. 2019 Mar;8(3):1022-1027
pubmed: 31041245
Medicine (Baltimore). 2018 Aug;97(32):e11875
pubmed: 30095666
Emerg Infect Dis. 2006 Feb;12(2):285-9
pubmed: 16494756
Case Rep Ophthalmol Med. 2016;2016:5704695
pubmed: 28078150
Indian J Pediatr. 2013 Jun;80(6):522-3
pubmed: 22961056
Lancet. 2002 Oct 5;360(9339):1070
pubmed: 12383989
Lancet. 1946 Jan 19;1(6386):92
pubmed: 21011278
Ophthalmol Ther. 2012 Dec;1(1):2
pubmed: 25135582
Int Ophthalmol. 2010 Oct;30(5):465-83
pubmed: 19711015
Curr Opin Ophthalmol. 2019 Nov;30(6):500-505
pubmed: 31503074
Middle East Afr J Ophthalmol. 2014 Oct-Dec;21(4):347-9
pubmed: 25371643
Ocul Immunol Inflamm. 2019;27(4):571-577
pubmed: 29370564
Indian J Med Res. 2012 Sep;136(3):373-90
pubmed: 23041731
Indian Pediatr. 2012 Sep;49(9):760
pubmed: 23024087