Innervation of the Human Intervertebral Disc: A Scoping Review.

Annulus Fibrosus Back Pain Humans Intervertebral Disc Intervertebral Disc Degeneration
Annulus Fibrosus Back Pain Intervertebral Disc Degeneration Neuroanatomy Nucleus Pulposus Peripheral Nervous System

Journal

Pain medicine (Malden, Mass.)
ISSN: 1526-4637
Titre abrégé: Pain Med
Pays: England
ID NLM: 100894201

Informations de publication

Date de publication:
04 06 2021
Historique:
pubmed: 18 2 2021
medline: 25 6 2021
entrez: 17 2 2021
Statut: ppublish

Résumé

Back pain is an elusive symptom complicated by a variety of possible causes, precipitating and maintaining factors, and consequences. Notably, the underlying pathology remains unknown in a significant number of cases. Changes to the intervertebral disc (IVD) have been associated with back pain, leading many to postulate that the IVD may be a direct source of pain, typically referred to as discogenic back pain. Yet despite decades of research into the neuroanatomy of the IVD, there is a lack of consensus in the literature as to the distribution and function of neural elements within the tissue. The current scoping review provides a comprehensive systematic overview of studies that document the topography, morphology, and immunoreactivity of neural elements within the IVD in humans. Articles were retrieved from six separate databases in a three-step systematic search and were independently evaluated by two reviewers. Three categories of neural elements were described within the IVD: perivascular nerves, sensory nerves independent of blood vessels, and mechanoreceptors. Nerves were consistently localized within the outer layers of the annulus fibrosus. Neural ingrowth into the inner annulus fibrosus and nucleus pulposus was found to occur only in degenerative and disease states. While the pattern of innervation within the IVD is clear, the specific topographic arrangement and function of neural elements in the context of back pain remains unclear.

Identifiants

DOI: 10.1093/pm/pnab070 PMID: 33595648 PMC: PMC8185559
pubmed: 33595648
pii: 6141029
doi: 10.1093/pm/pnab070
pmc: PMC8185559
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1281-1304

Subventions

Organisme : CIHR
ID : 115068
Pays : Canada

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Références

N Engl J Med. 1994 Jul 14;331(2):69-73
pubmed: 8208267
J Clin Neurosci. 2010 Jan;17(1):87-91
pubmed: 19969463
Spine (Phila Pa 1976). 2017 Apr 15;42(8):540-546
pubmed: 27438387
JBMR Plus. 2019 Mar 04;3(5):e10180
pubmed: 31131347
World Neurosurg. 2018 Nov;119:e686-e693
pubmed: 30092465
Arthritis Res Ther. 2014 Aug 20;16(5):416
pubmed: 25209447
Sao Paulo Med J. 2010;128(2):63-8
pubmed: 20676571
J Bone Joint Surg Br. 1997 Jan;79(1):147-53
pubmed: 9020464
N Engl J Med. 2001 Feb 1;344(5):363-70
pubmed: 11172169
Spine (Phila Pa 1976). 2006 Apr 20;31(9):1026-31
pubmed: 16641780
Spine (Phila Pa 1976). 2006 Aug 15;31(18):2151-61
pubmed: 16915105
Spine (Phila Pa 1976). 1995 Dec 15;20(24):2645-51
pubmed: 8747242
JAMA. 2010 Apr 7;303(13):1295-302
pubmed: 20371789
J Pathol. 1980 Oct;132(2):95-104
pubmed: 6448280
Spine (Phila Pa 1976). 1996 Aug 15;21(16):1848-51
pubmed: 8875714
Spine (Phila Pa 1976). 1997 Oct 15;22(20):2342-9; discussion 2349-50
pubmed: 9355214
J Bone Joint Surg Am. 1966 Oct;48(7):1272-81
pubmed: 5921784
Neurosurgery. 2017 Mar 01;80(3S):S46-S54
pubmed: 28350945
Spine (Phila Pa 1976). 1999 Oct 15;24(20):2075-9
pubmed: 10543001
J Orthop Res. 1994 Mar;12(2):186-92
pubmed: 8164090
Spine (Phila Pa 1976). 2006 Oct 1;31(21):2418-22
pubmed: 17023849
J Pain. 2014 Apr;15(4):378-86
pubmed: 24389017
Spine (Phila Pa 1976). 2002 Jan 15;27(2):135-40
pubmed: 11805657
J Clin Neurosci. 2010 Jun;17(6):742-5
pubmed: 20347312
Spine (Phila Pa 1976). 2006 Nov 1;31(23):2724-7
pubmed: 17077742
J Anat. 2010 Jul;217(1):1-15
pubmed: 20456524
Spine Surg Relat Res. 2018 Jan 27;2(1):11-17
pubmed: 31440640
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Arthritis Res Ther. 2009;11(4):R126
pubmed: 19695094
Spine (Phila Pa 1976). 1988 Jan;13(1):2-8
pubmed: 3381132
J Bone Joint Surg Am. 1956 Apr;38-A(2):377-91
pubmed: 13319400
Ann Intern Med. 2017 Apr 4;166(7):514-530
pubmed: 28192789
PLoS One. 2012;7(10):e47735
pubmed: 23091643
Nat Rev Dis Primers. 2018 Dec 13;4(1):52
pubmed: 30546064
Nat Med. 2007 Jul;13(7):803-11
pubmed: 17603492
JOR Spine. 2020 Sep 15;3(4):e1123
pubmed: 33392458
Spine (Phila Pa 1976). 2012 Jan 1;37(1):2-9
pubmed: 21386768
J Neurosurg Spine. 2008 Sep;9(3):285-95
pubmed: 18928227
Biorheology. 2000;37(1-2):185-90
pubmed: 10912191
Spine (Phila Pa 1976). 2007 May 20;32(12):1295-302
pubmed: 17515817
Ann Intern Med. 2018 Oct 2;169(7):467-473
pubmed: 30178033
Spine (Phila Pa 1976). 2004 Dec 1;29(23):2700-9
pubmed: 15564919
Acta Anat (Basel). 1967;68(3):321-33
pubmed: 5591904
Cell Mol Life Sci. 2016 Nov;73(22):4249-4264
pubmed: 27314883
Acta Orthop Scand. 1949;19(2):211-21, illust
pubmed: 15400963
F1000Res. 2019 Sep 12;8:
pubmed: 31559013
Lancet. 1997 Jul 19;350(9072):178-81
pubmed: 9250186
J Cell Biol. 2018 May 7;217(5):1869-1882
pubmed: 29490939
Spine (Phila Pa 1976). 1999 Nov 15;24(22):2295-9
pubmed: 10586451
Science. 2004 Aug 13;305(5686):1007-9
pubmed: 15310904
Nat Rev Rheumatol. 2014 Jan;10(1):44-56
pubmed: 24166242
Lancet. 1990 Jul 21;336(8708):189-90
pubmed: 1973516
Spine (Phila Pa 1976). 2004 Dec 1;29(23):2679-90
pubmed: 15564917
Cell Tissue Res. 2019 Jan;375(1):227-241
pubmed: 30284083
J Anat. 2018 Jul;233(1):86-97
pubmed: 29708266
Spine (Phila Pa 1976). 2001 Dec 1;26(23):2550-7
pubmed: 11725235
Pain Med. 2019 Jun 1;20(6):1072-1077
pubmed: 30848823
J Pathol. 2002 Jul;197(3):286-92
pubmed: 12115873
J Anat. 1981 Jan;132(Pt 1):39-56
pubmed: 7275791
Biometrics. 1977 Mar;33(1):159-74
pubmed: 843571
Spine (Phila Pa 1976). 2012 Oct 15;37(22):1883-91
pubmed: 22706090
J Cell Mol Med. 2014 Jun;18(6):1213-25
pubmed: 24650225
Spine J. 2014 Mar 1;14(3):513-21
pubmed: 24139753
Bull Johns Hopkins Hosp. 1963 Dec;113:347-51
pubmed: 14089497
Arthritis Res Ther. 2015 Dec 21;17:370
pubmed: 26695177
J Orthop Res. 2016 Aug;34(8):1456-65
pubmed: 27155444
J Bone Joint Surg Br. 2005 Jan;87(1):62-7
pubmed: 15686239
Spine (Phila Pa 1976). 1992 Feb;17(2):132-5
pubmed: 1372767
Acta Anat (Basel). 1959;38:96-113
pubmed: 14420325

Auteurs

Adam M R Groh (AMR)

Integrated Program in Neuroscience, The Montreal Neurological Institute-Hospital, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
ORCID: 0000-0002-5878-0973

Dale E Fournier (DE)

Health and Rehabilitation Sciences (Physical Therapy), Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.
Bone and Joint Institute, University of Western Ontario, London, Ontario, Canada.
ORCID: 0000-0001-6572-8447

Michele C Battié (MC)

Bone and Joint Institute, University of Western Ontario, London, Ontario, Canada.
School of Physical Therapy, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.
ORCID: 0000-0001-8499-2040

Cheryle A Séguin (CA)

Bone and Joint Institute, University of Western Ontario, London, Ontario, Canada.
Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.
ORCID: 0000-0001-6503-9107

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Anneau fibreux › Innervation of the Human Intervertebral Disc:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dorsalgie › Innervation of the Human Intervertebral Disc:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Innervation of the Human Intervertebral Disc:...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Innervation of the Human Intervertebral Disc:...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › Innervation of the Human Intervertebral Disc:...