Intra-individual cytokine profile in peri-implantitis and periodontitis: A cross-sectional study.
cytokines
inflammation
peri-implantitis
periodontitis
Journal
Clinical oral implants research
ISSN: 1600-0501
Titre abrégé: Clin Oral Implants Res
Pays: Denmark
ID NLM: 9105713
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
27
12
2020
received:
23
02
2020
accepted:
27
01
2021
pubmed:
18
2
2021
medline:
15
5
2021
entrez:
17
2
2021
Statut:
ppublish
Résumé
To study cytokine profiles and intra-individual correlations in crevicular fluid samples at periodontitis, peri-implantitis, and healthy sites. Samples from gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) were collected from healthy and diseased sites in patients who had had dental implants for a minimum of 10 years. Cytokine levels were analyzed using the Bio-Plex Pro Human inflammation kit, which included biomarkers for the tumor necrosis factor-α (TNF-α) superfamily, regulatory T Cell (Treg) cytokines, and interferon (IFN) proteins. Gingival crevicular fluid/PICF cytokine levels, determined in samples from 163 patients, were frequently lower for healthy tooth and implant sites compared to sites with periodontitis or peri-implantitis. In contrast, there were no significant differences in cytokine levels between peri-implant sites and periodontitis sites. Intra-individual correlations between cytokines at peri-implant sites were frequently significant. In addition, the cytokines IFN-λ1 and TNFSF12 were significantly correlated with the presence of peri-implantitis. Within the limits of this study, the intra-individual cytokine profile did not differ between sites diagnosed with periodontitis and those diagnosed with peri-implantitis, but did differ between healthy tooth and healthy implant sites. Studying intra-individual cytokine profiles is a method to elucidate possible differences between the etiopathogeneses of periodontitis and peri-implantitis, since it is well known that immune responses to dysbiosis vary between individuals according to host factors. Thus, the findings of the present study are potentially relevant to the advancement of knowledge in this field.
Substances chimiques
Cytokines
0
Dental Implants
0
Types de publication
Journal Article
Langues
eng
Pagination
559-568Subventions
Organisme : Folktandvården Stockholms län AB, Sweden
Organisme : The Swedish Research Council, Sweden
Organisme : The Swedish Dental Society, Sweden
Organisme : Stockholm County Council, Sweden
Informations de copyright
© 2021 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.
Références
Abe, T., AlSarhan, M., Benakanakere, M. R., Maekawa, T., Kinane, D. F., Cancro, M. P., Korostoff, J. M., & Hajishengallis, G. (2015). The B Cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B Cell-dependent bone loss in experimental Murine Periodontitis. Journal of Immunology, 195(4), 1427-1435. https://doi.org/10.4049/jimmunol.1500496
Ainamo, J., & Bay, I. (1975). Problems and proposals for recording gingivitis and plaque. International Dental Journal, 25(4), 229-235.
Armitage, G. C. (2004). The complete periodontal examination. Periodontology 2000, 34, 22-33. https://doi.org/10.1046/j.0906-6713.2002.003422.x
Berglundh, T., Armitage, G., Araujo, M. G., Avila-Ortiz, G., Blanco, J., Camargo, P. M., Chen, S., Cochran, D., Derks, J., Figuero, E., Hämmerle, C. H. F., Heitz-Mayfield, L. J. A., Huynh-Ba, G., Iacono, V., Koo, K.-T., Lambert, F., McCauley, L., Quirynen, M., Renvert, S., … Zitzmann, N. (2018). Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the classification of periodontal and peri-implant diseases and conditions. Journal of Clinical Periodontology, 45(Suppl 20), S286-S291. https://doi.org/10.1111/jcpe.12957
Bertin, D., Stephan, D., Khrestchatisky, M., & Desplat-Jego, S. (2013). Is TWEAK a biomarker for autoimmune/chronic inflammatory diseases? Frontiers in Immunology, 4, 489. https://doi.org/10.3389/fimmu.2013.00489
Brunetti, G., Faienza, M. F., Colaianni, G., Gigante, I., Oranger, A., Pignataro, P., & Grano, M. (2018). Impairment of bone remodeling in LIGHT/TNFSF14-deficient mice. Journal of Bone and Mineral Research, 33(4), 704-719. https://doi.org/10.1002/jbmr.3345
Brunetti, G., Rizzi, R., Storlino, G., Bortolotti, S., Colaianni, G., Sanesi, L., Lippo, L., Faienza, M. F., Mestice, A., Curci, P., Specchia, G., Grano, M., & Colucci, S. (2018). LIGHT/TNFSF14 as a New biomarker of bone disease in multiple myeloma patients experiencing therapeutic regimens. Frontiers in Immunology, 9, 2459. https://doi.org/10.3389/fimmu.2018.02459
Buduneli, N., & Kinane, D. F. (2011). Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. Journal of Clinical Periodontology, 38(Suppl 11), 85-105. https://doi.org/10.1111/j.1600-051X.2010.01670.x
Darveau, R. P. (2010). Periodontitis: A polymicrobial disruption of host homeostasis. Nature Reviews: Microbiology, 8(7), 481-490. https://doi.org/10.1038/nrmicro2337
Duarte, P. M., de Mendonça, A. C., Máximo, M. B., Santos, V. R., Bastos, M. F., & Nociti, F. H. (2009). Effect of anti-infective mechanical therapy on clinical parameters and cytokine levels in human peri-implant diseases. Journal of Periodontology, 80(2), 234-243. https://doi.org/10.1902/jop.2009.070672
Duarte, P. M., Serrão, C. R., Miranda, T. S., Zanatta, L. C. S., Bastos, M. F., Faveri, M., Figueiredo, L. C., & Feres, M. (2016). Could cytokine levels in the peri-implant crevicular fluid be used to distinguish between healthy implants and implants with peri-implantitis? A systematic review. Journal of Periodontal Research, 51(6), 689-698. https://doi.org/10.1111/jre.12354
Edwards, J. R., Sun, S. G., Locklin, R., Shipman, C. M., Adamopoulos, I. E., Athanasou, N. A., & Sabokbar, A. (2006). LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis and Rheumatism, 54(5), 1451-1462. https://doi.org/10.1002/art.21821
Frederic, L. J., Michel, B., & Selena, T. (2018). Oral microbes, biofilms and their role in periodontal and peri-implant diseases. Materials, 11(10), 1802. https://doi.org/10.3390/ma11101802
Gamonal, J., Acevedo, A., Bascones, A., Jorge, O., & Silva, A. (2001). Characterization of cellular infiltrate, detection of chemokine receptor CCR5 and interleukin-8 and RANTES chemokines in adult periodontitis. Journal of Periodontal Research, 36(3), 194-203. https://doi.org/10.1034/j.1600-0765.2001.360309.x
Ghallab, N. A. (2018). Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence. Archives of Oral Biology, 87, 115-124. https://doi.org/10.1016/j.archoralbio.2017.12.022
Giannobile, W. V., Beikler, T., Kinney, J. S., Ramseier, C. A., Morelli, T., & Wong, D. T. (2009). Saliva as a diagnostic tool for periodontal disease: Current state and future directions. Periodontology 2000, 50, 52-64. https://doi.org/10.1111/j.1600-0757.2008.00288.x
Gurlek, O., Gumus, P., Nile, C. J., Lappin, D. F., & Buduneli, N. (2017). Biomarkers and bacteria around implants and natural teeth in the same individuals. Journal of Periodontology, 88(8), 752-761. https://doi.org/10.1902/jop.2017.160751
Hajishengallis, G., & Lamont, R. J. (2012). Beyond the red complex and into more complexity: The polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Molecular Oral Microbiology, 27(6), 409-419. https://doi.org/10.1111/j.2041-1014.2012.00663.x
Kinane, D. F., Preshaw, P. M., & Loos, B. G. (2011). Host-response: Understanding the cellular and molecular mechanisms of host-microbial interactions-consensus of the Seventh European Workshop on Periodontology. Journal of Clinical Periodontology, 38(Suppl 11), 44-48. https://doi.org/10.1111/j.1600-051X.2010.01682.x
Koldsland, O. C., Scheie, A. A., & Aass, A. M. (2010). Prevalence of peri-implantitis related to severity of the disease with different degrees of bone loss. Journal of Periodontology, 81(2), 231-238. https://doi.org/10.1902/jop.2009.090269
Korte, D. L., & Kinney, J. (2016). Personalized medicine: An update of salivary biomarkers for periodontal diseases. Periodontology 2000, 70(1), 26-37. https://doi.org/10.1111/prd.12103
Loos, B. G., & Tjoa, S. (2005). Host-derived diagnostic markers for periodontitis: Do they exist in gingival crevice fluid? Periodontology 2000, 39, 53-72. https://doi.org/10.1111/j.1600-0757.2005.00129.x
Lopalco, G., Lucherini, O. M., Lopalco, A., Venerito, V., Fabiani, C., Frediani, B., Galeazzi, M., Lapadula, G., Cantarini, L., & Iannone, F. (2017). Cytokine Signatures in Mucocutaneous and Ocular Behcet's Disease. Frontiers in Immunology, 8, 200. https://doi.org/10.3389/fimmu.2017.00200
Lundmark, A., Hu, Y. O. O., Huss, M., Johannsen, G., Andersson, A. F., & Yucel-Lindberg, T. (2019). Identification of salivary microbiota and its association with host inflammatory mediators in Periodontitis. Frontiers in Cellular and Infection Microbiology, 21(9), 216. https://doi.org/10.3389/fcimb.2019.00216
Lundmark, A., Johannsen, G., Eriksson, K., Kats, A., Jansson, L., Tervahartiala, T., Rathnayake, N., Åkerman, S., Klinge, B., Sorsa, T., & Yucel-Lindberg, T. (2017). Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis. Journal of Clinical Periodontology, 44(3), 247-254. https://doi.org/10.1111/jcpe.12670
Maecker, H., Varfolomeev, E., Kischkel, F., Lawrence, D., LeBlanc, H., Lee, W., Hurst, S., Danilenko, D., Li, J., Filvaroff, E., Yang, B., Daniel, D., & Ashkenazi, A. (2005). TWEAK attenuates the transition from innate to adaptive immunity. Cell, 123(5), 931-944. https://doi.org/10.1016/j.cell.2005.09.022
Nazar Majeed, Z., Philip, K., Alabsi, A. M., Pushparajan, S., & Swaminathan, D. (2016). Identification of gingival crevicular fluid sampling, analytical methods, and oral biomarkers for the diagnosis and monitoring of periodontal diseases: A systematic review. Disease Markers, 2016, 1804727, https://doi.org/10.1155/2016/1804727
Nile, C. J., Sherrabeh, S., Ramage, G., & Lappin, D. F. (2013). Comparison of circulating tumour necrosis factor superfamily cytokines in periodontitis patients undergoing supportive therapy: A case-controlled cross-sectional study comparing smokers and non-smokers in health and disease. Journal of Clinical Periodontology, 40(9), 875-882. https://doi.org/10.1111/jcpe.12134
Nogueira-Filho, G., Pesun, I., Isaak-Ploegman, C., Wijegunasinghe, M., Wierzbicki, T., & McCulloch, C. A. (2014). Longitudinal comparison of cytokines in peri-implant fluid and gingival crevicular fluid in healthy mouths. Journal of Periodontology, 85(11), 1582-1588. https://doi.org/10.1902/jop.2014.130642
Nowzari, H., Phamduong, S., Botero, J. E., Villacres, M. C., & Rich, S. K. (2012). The profile of inflammatory cytokines in gingival crevicular fluid around healthy osseointegrated implats. Clinical Implant Dentistry and Related Research, 14(4), 546-552. https://doi.org/10.1111/j.1708-8208
Raj, S. C., Panda, S. M., Dash, M., Patnaik, K., Mohanty, D., Katti, N., Mahapatra, A., Mishra, D., & Praharaj, K. (2018). Association of human interleukin-35 level in gingival crevicular fluid and serum in periodontal health, disease, and after nonsurgical therapy: A comparative study. Contemporary Clinical Dentistry, 9(2), 293-297. https://doi.org/10.4103/ccd.ccd_51_18
Schwarz, F., Derks, J., Monje, A., & Wang, H. L. (2018). Peri-implantitis. Journal of Periodontology, 89(Suppl 1), S267-S290. https://doi.org/10.1002/jper.16-0350
Severino, V. O., Napimoga, M. H., & de Lima Pereira, S. A. (2011). Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis. Archives of Oral Biology, 56(8), 823-828. https://doi.org/10.1016/j.archoralbio.2011.01.006
Souza, P. P., & Lerner, U. H. (2013). The role of cytokines in inflammatory bone loss. Immunological Investigations, 42(7), 555-622. https://doi.org/10.3109/08820139.2013.822766
Yaghobee, S., Khorsand, A., Rasouli Ghohroudi, A. A., Sanjari, K., & Kadkhodazadeh, M. (2014). Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: A cross-sectional study. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 40(5), 220-224. https://doi.org/10.5125/jkaoms.2014.40.5.220
Yakar, N., Guncu, G., Akman, A., Pinar, A., Karabulut, E., & Nohutcu, R. (2019). Evaluation of gingival crevicular fluid and periimplant crevicular fluid levels of sclerostin, TWEAK, RANKL and OPG. Cytokine, 113, 433-439. https://doi.org/10.1016/j.cyto.2018.10.021
Yucel-Lindberg, T., & Bage, T. (2013). Inflammatory mediators in the pathogenesis of periodontitis. Expert Reviews in Molecular Medicine, 15, e7. https://doi.org/10.1017/erm.2013.8
Zani, S. R., Moss, K., Shibli, J. A., Teixeira, E. R., de Oliveira Mairink, R., Onuma, T., Feres, M., & Teles, R. P. (2016). Peri-implant crevicular fluid biomarkers as discriminants of peri-implant health and disease. Journal of Clinical Periodontology, 43(10), 825-832. https://doi.org/10.1111/jcpe.12586