Circumferential trabecular meshwork cell density in the human eye.
Aqueous humor
Glaucoma
Human
Morphometry
Segmental outflow
Trabecular meshwork
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
23
07
2020
revised:
04
02
2021
accepted:
09
02
2021
pubmed:
18
2
2021
medline:
4
9
2021
entrez:
17
2
2021
Statut:
ppublish
Résumé
The cells residing in the trabecular meshwork (TM) fulfill important roles in the maintenance of the tissue and the regulation of intraocular pressure (IOP). Here we examine (i) TM cell distribution along the circumference of the human eye, (ii) differences in TM cell density between regions of high and low outflow, and (iii) whether TM cell distribution in eyes from donors with primary open angle glaucoma (POAG) differs from that of normal eyes. Toward this end, the TM cell density from 12 radial segments around the circumference of the TM of human donor eyes (n = 6) with and without POAG was determined using histochemical methods. Areas of high, median, and low outflow were mapped in a different set of human donor eyes that were perfused in organ culture, and TM cell densities in these areas were determined in normal (n = 11) and POAG eyes (n = 6). Our analysis of 1380 tissue sections taken from the first set of six eyes shows that the average TM cell density of these six eyes ranges from 15.5 to 23.7 cells/100 μm and is negatively correlated to the maximum IOP recorded for each donor eye (R
Identifiants
pubmed: 33596442
pii: S0014-4835(21)00059-2
doi: 10.1016/j.exer.2021.108494
pmc: PMC8044015
mid: NIHMS1675058
pii:
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108494Subventions
Organisme : RRD VA
ID : I01 RX001163
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026048
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY025580
Pays : United States
Organisme : RRD VA
ID : I50 RX003002
Pays : United States
Organisme : RRD VA
ID : I01 RX002860
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
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