Glutamate transporters have a chloride channel with two hydrophobic gates.
Amino Acid Transport System X-AG
/ chemistry
Animals
Brain
/ metabolism
Chloride Channels
/ chemistry
Chlorides
/ metabolism
Cryoelectron Microscopy
Crystallography, X-Ray
Excitatory Amino Acid Transporter 1
/ chemistry
Female
Glutamic Acid
/ metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Mutation
Oocytes
Protein Conformation
Xenopus laevis
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
25
05
2020
accepted:
13
01
2021
pubmed:
19
2
2021
medline:
1
9
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and its precise control is vital to maintain normal brain function and to prevent excitotoxicity
Identifiants
pubmed: 33597752
doi: 10.1038/s41586-021-03240-9
pii: 10.1038/s41586-021-03240-9
pmc: PMC7954978
mid: NIHMS1663144
doi:
Substances chimiques
Amino Acid Transport System X-AG
0
Chloride Channels
0
Chlorides
0
Excitatory Amino Acid Transporter 1
0
SLC1A3 protein, human
0
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-331Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM104601
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM067887
Pays : United States
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