A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5.
Kv1.5
Oculicosa supermirabilis
atrial fibrillation
recombinant expression
spider venom
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
05
2020
accepted:
26
10
2020
entrez:
18
2
2021
pubmed:
19
2
2021
medline:
19
2
2021
Statut:
epublish
Résumé
Spider venoms include various peptide toxins that modify the ion currents, mainly of excitable insect cells. Consequently, scientific research on spider venoms has revealed a broad range of peptide toxins with different pharmacological properties, even for mammal species. In this work, thirty animal venoms were screened against hK
Identifiants
pubmed: 33597864
doi: 10.3389/fphar.2020.563858
pii: 563858
pmc: PMC7883638
doi:
Types de publication
Journal Article
Langues
eng
Pagination
563858Informations de copyright
Copyright © 2021 Diana Alvarado, Cardoso-Arenas, Corrales-García, Clement, Arenas, Montero-Dominguez, Olamendi-Portugal, Zamudio, Agota, Borrego, Panyi, Papp and Corzo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer EU declared a past co-authorship with one of the authors GP to the handling editor.
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