Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population.
Aging
Arterial stiffness
Person-specific arterial ventricular coupling
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
19
10
2020
accepted:
22
12
2020
pubmed:
19
2
2021
medline:
1
6
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Although mechanical energy transfer between the heart and arterial system, referred to as arterial-ventricular (AV) coupling, is an important determinant of cardiovascular performance, how AV coupling changes over time within and among individuals as they age has not been fully explored. We studied 129 participants (baseline age 21-96) of the Baltimore Longitudinal Study of Aging, free of clinical CVD. Participants underwent repeated multigated cardiac blood pool scans to estimate left ventricular (LV) volumes (SV, EDV, and ESV). Total systemic vascular resistance (TSVR), total arterial compliance (TAC), effective arterial elastance (Ea), and end-systolic LV elastance (Elv) were calculated using LV volumes and brachial BP measurements; calculated Ea/Elv was the measure of AV coupling. Linear mixed-effects models were used to estimate person-specific rates of change (Change) for each variable. The rate at which Ea increased over time was faster than the rate at which Elv increased, resulting in AV uncoupling (increased Ea/Elv) over time that was significantly greater in women than in men. Loss of arterial compliance was the main determinant of (Ea/Elv)
Identifiants
pubmed: 33598853
doi: 10.1007/s11357-020-00321-x
pii: 10.1007/s11357-020-00321-x
pmc: PMC8110622
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
551-561Références
Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Circulation. 2003;107(2):346–54.
doi: 10.1161/01.CIR.0000048893.62841.F7
Nichols WW, O’Rourke MF, Avolio AP, et al. Effects of age on ventricular-vascular coupling. Am J Cardiol. 1985;55(9):1179–84.
doi: 10.1016/0002-9149(85)90659-9
Little WC, Cheng CP. Left ventricular-arterial coupling in conscious dogs. Am J Physiol - Hear Circ Physiol. 1991;261(1 30–1).
Little WC, Che Ping Cheng. Effect of exercise on left ventricular-arterial coupling assessed in the pressure-volume plane. Am J Physiol - Hear Circ Physiol. 1993;264(5 33–5).
Chen CH, Nakayama M, Nevo E, Fetics BJ, Lowell Maughan W, Kass DA. Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol. 1998;32(5):1221–7.
doi: 10.1016/S0735-1097(98)00374-X
Ikonomidis I, Aboyans V, Blacher J, Brodmann M, Brutsaert DL, Chirinos JA, et al. The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on aorta & peripheral vascular diseases, European Association of Cardiovascular Imaging, and heart failure association. Eur J Heart Fail. 2019;21(4):402–24.
doi: 10.1002/ejhf.1436
Chantler PD, Lakatta EG, Najjar SS. Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise. J Appl Physiol. 2008;105(4):1342–51.
doi: 10.1152/japplphysiol.90600.2008
AlGhatrif M, Strait JB, Morrell CH, Canepa M, Wright J, Elango P, et al. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore longitudinal study of aging. Hypertension. 2013;62(5):934–51.
doi: 10.1161/HYPERTENSIONAHA.113.01445
Scuteri A, Morrell CH, Orrù M, et al. Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging. Hypertension Published online September 15, 2014.
Scantlebury DC, Borlaug BA. Why are women more likely than men to develop heart failure with preserved ejection fraction? Curr Opin Cardiol. 2011;26(6):562–8.
doi: 10.1097/HCO.0b013e32834b7faf
Sunagawa K, Maughan WL, Burkhoff D, Sagawa K. Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol - Hear Circ Physiol. 1983;14(5).
Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005;112(15):2254–62.
doi: 10.1161/CIRCULATIONAHA.105.541078
Chen C-H, Nakayama M, Talbot M, Nevo E, Fetics B, Gerstenblith G, et al. Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals. J Am Coll Cardiol. 1999;33:1602–9.
doi: 10.1016/S0735-1097(99)00052-2
Senzaki H, Chen CH, Kass DA. Single-beat estimation of end-systolic pressure-volume relation in humans: a new method with the potential for noninvasive application. Circulation. 1996;94(10):2497–506.
doi: 10.1161/01.CIR.94.10.2497
Park S, Ha JW, Shim CY, et al. Gender-related difference in arterial elastance during exercise in patients with hypertension. Hypertension. 2008;51(4 PART 2 SUPPL.):1163–1169.
Saba PS, Ganau A, Devereux RB, Pini R, Pickering TG, Roman MJ. Impact of arterial elastance as a measure of vascular load on left ventricular geometry in hypertension. J Hypertens. 1999;17(7):1007–15.
doi: 10.1097/00004872-199917070-00018
Kelly RP, Ting CT, Yang TM, Liu CP, Maughan WL, Chang MS, et al. Effective arterial elastance as index of arterial vascular load in humans. Circulation. 1992;86(2):513–21.
doi: 10.1161/01.CIR.86.2.513
Najjar SS, Schulman SP, Gerstenblith G, et al. Age and gender affect ventricular-vascular coupling during aerobic exercise. J Am Coll Cardiol. 2004;44:611–7 ST-Age and gender affect ventricular-vasc.
Chantler PD, Lakatta EG. Arterial-ventricular coupling with aging and disease. Front Physiol. 2012;3:90.
doi: 10.3389/fphys.2012.00090
Segers P, Stergiopulos N, Westerhof N. Relation of effective arterial elastance to arterial system properties. Am J Physiol - Hear Circ Physiol. 2002;282(3 51–3).
De Tombe PP, Jones S, Burkhoff D, Hunter WC, Kass DA. Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading. Am J Physiol - Hear Circ Physiol. 1993;264(6 33–6).
Cohen-Solal A, Caviezel B, Laperche T, Gourgon R. Effects of aging on left ventricular-arterial coupling in man: assessment by means of arterial effective and left ventricular elastances. J Hum Hypertens. 1996;10(2):111–6.
pubmed: 8867565
Borlaug BA, Redfield MM, Melenovsky V, Kane GC, Karon BL, Jacobsen SJ, et al. Longitudinal changes in left ventricular stiffness a community-based study. Circ Hear Fail. 2013;6(5):944–52.
doi: 10.1161/CIRCHEARTFAILURE.113.000383
Ferrucci L. The Baltimore longitudinal study of aging (BLSA): a 50-year-long journey and plans for the future. J Gerontol A Biol Sci Med Sci. 2008;63(12):1416–9.
doi: 10.1093/gerona/63.12.1416
Oberdier MT, Morrell CH, Lakatta EG, Ferrucci L, AlGhatrif M. Subclinical longitudinal change in ankle-brachial index with aging in a community-dwelling population is associated with central arterial stiffening. J Am Heart Assoc. 2019;8(15).
Karikkineth A, AlGhatrif M, Oberdier MT, et al. Sex differences in longitudinal determinants of carotid intima media thickening with aging in a community dwelling population: the Baltimore Longitudinal Study on Aging. JAHA. 2020;In press.
Schulman SP, Lakatta EG, Fleg JL, Lakatta L, Becker LC, Gerstenblith G. Age-related decline in left ventricular filling at rest and exercise. Am J Physiol - Hear Circ Physiol. 1992;263(6 32–6).
Chen CH, Nevo E, Fetics B, Pak PH, Yin FCP, Maughan WL, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation. 1997;95(7):1827–36.
doi: 10.1161/01.CIR.95.7.1827
Morrell CH, Brant LJ, Ferrucci L. Model choice can obscure results in longitudinal studies. Journals Gerontol Ser A Biol Sci Med Sci. 2009;64A(2):215–22.
doi: 10.1093/gerona/gln024
Kass DA. Age-related changes in venticular-arterial coupling: pathophysiologic implications. Heart Fail Rev. 2002;7:51–62.
doi: 10.1023/A:1013749806227
AlGhatrif M, Wang M, Fedorova OV, Bagrov AY, Lakatta EG. The pressure of aging. Med Clin North Am. 2017;101(1):81–101.
doi: 10.1016/j.mcna.2016.08.006
Renlund DG, Gerstenblith G, Fleg JL, Becker LC, Lakatta EG. Interaction between left ventricular end-diastolic and end-systolic volumes in normal humans. Am J Phys. 1990;258(2 Pt 2):H473–81.
Lam CSP, Roger VL, Rodeheffer RJ, et al. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation. 2007;115(15):1982–90.
doi: 10.1161/CIRCULATIONAHA.106.659763
Brinker SK, Pandey A, Ayers CR, Barlow CE, DeFina LF, Willis BL, et al. Association of cardiorespiratory fitness with left ventricular remodeling and diastolic function: the Cooper center longitudinal study. JACC Hear Fail. 2014;2(3):238–46.
doi: 10.1016/j.jchf.2014.01.004
Nwabuo CC, Moreira HT, Vasconcellos HD, Ambale-Venkatesh B, Yoneyama K, Ohyama Y, et al. Association of aortic root dilation from early adulthood to middle age with cardiac structure and function: the CARDIA study. J Am Soc Echocardiogr. 2017;30(12):1172–9.
doi: 10.1016/j.echo.2017.08.001