Link between Mild Traumatic Brain Injury, Poor Sleep, and Magnetic Resonance Imaging: Visible Perivascular Spaces in Veterans.
MRI
all sleep disorders
brain trauma
glymphatic
perivascular spaces
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
pubmed:
19
2
2021
medline:
23
2
2022
entrez:
18
2
2021
Statut:
ppublish
Résumé
Impaired clearance of perivascular waste in the brain may play a critical role in morbidity after mild traumatic brain injury (mTBI). We aimed to determine the effect of mTBI on the burden of magnetic resonance imaging (MRI)-visible perivascular spaces (PVSs) in a cohort of U.S. military veterans and whether sleep modulates this effect. We also investigated the correlation between PVS burden and severity of persistent post-concussive symptoms. Fifty-six Iraq/Afghanistan veterans received 3 Tesla MRI as part of a prospective cohort study on military blast mTBI. White matter PVS burden (i.e., number and volume) was calculated using an established automated segmentation algorithm. Multi-variate regression was used to establish the association between mTBIs sustained in the military and PVS burden. Covariates included age, blood pressure, number of impact mTBIs outside the military, and blast exposures. Correlation coefficients were calculated between PVS burden and severity of persistent post-concussive symptoms. There was a significant positive relationship between the number of mTBIs sustained in the military and both PVS number and volume (
Identifiants
pubmed: 33599176
doi: 10.1089/neu.2020.7447
pmc: PMC8390772
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2391-2399Subventions
Organisme : NIA NIH HHS
ID : P30 AG066518
Pays : United States
Organisme : RRD VA
ID : I01 RX000521
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL150217
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089709
Pays : United States
Organisme : RRD VA
ID : I01 RX001612
Pays : United States
Organisme : RRD VA
ID : I01 RX003087
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066509
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054456
Pays : United States
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