Spatially constrained kinetic modeling with dual reference tissues improves
18F-Flortaucipir PET
Alzheimer disease
Dual reference tissues
Logan plot
SRTM
SUVR
Spatially constrained kinetic modeling
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
19
07
2020
accepted:
20
11
2020
pubmed:
19
2
2021
medline:
18
9
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Recent studies have shown that standard compartmental models using plasma input or the cerebellum reference tissue input are generally not reliable for quantifying tau burden in dynamic Participants were classified as either cognitively normal (CN) or cognitively impaired (CI) based on clinical assessment. T1-weighted structural MRI and 105-min dynamic The percent coefficients of variation of R Using a spatially constrained kinetic model with dual reference tissues significantly improved quantification of relative perfusion and tau binding. Cerebellum and CS are the suggested reference tissues to estimate R
Identifiants
pubmed: 33599811
doi: 10.1007/s00259-020-05134-w
pii: 10.1007/s00259-020-05134-w
pmc: PMC8371062
mid: NIHMS1699360
doi:
Substances chimiques
Carbolines
0
tau Proteins
0
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
J09QS3Z3WB
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3172-3186Subventions
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150891
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB025815
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG032438
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG042791
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG064937
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG059798
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NIH HHS
ID : S10 OD025214
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052550
Pays : United States
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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