Melting transition of oriented Li-DNA fibers submerged in ethanol solutions.


Journal

Biopolymers
ISSN: 1097-0282
Titre abrégé: Biopolymers
Pays: United States
ID NLM: 0372525

Informations de publication

Date de publication:
Mar 2021
Historique:
revised: 08 01 2021
received: 28 10 2020
accepted: 21 01 2021
pubmed: 19 2 2021
medline: 26 10 2021
entrez: 18 2 2021
Statut: ppublish

Résumé

The melting transition of Li-DNA fibers immersed in ethanol-water solutions has been studied using calorimetry and neutron diffraction techniques. The data have been analyzed using the Peyrard-Bishop-Dauxois model to determine the strengths of the intra- and inter-base pair potentials. The data and analysis show that the potentials are weaker than those for DNA in water. They become weaker still and the DNA less stable as the ethanol concentration increases but, conversely, the fibers become more compact and the distances between base pairs become more regular. The results show that the melting transition is relatively insensitive to local confinement and depends more on the interaction between the DNA and its aqueous environment.

Identifiants

pubmed: 33600618
doi: 10.1002/bip.23422
doi:

Substances chimiques

Solutions 0
Water 059QF0KO0R
Ethanol 3K9958V90M
DNA 9007-49-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e23422

Subventions

Organisme : European Regional Development Fund and Greece
ID : MIS 5002409 NSRF 2014-2020
Organisme : Institut Laue-Langevin

Informations de copyright

© 2021 Wiley Periodicals LLC.

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Auteurs

Adrián González (A)

Institut Laue-Langevin, Grenoble, France.
ICCRAM, University of Burgos, Burgos, Spain.
Nano and Biophysics division, Department of Physics, Chalmers University of Technology, Göteborg, Sweden.

Andrew R Wildes (AR)

Institut Laue-Langevin, Grenoble, France.

Estelle Mossou (E)

Institut Laue-Langevin, Grenoble, France.

Viviana Cristiglio (V)

Institut Laue-Langevin, Grenoble, France.

Gaël Moiroux (G)

Institut Néel, CNRS, Grenoble, France.
Institut Néel, University Grenoble Alpes, Grenoble, France.

Jean-Luc Garden (JL)

Institut Néel, CNRS, Grenoble, France.
Institut Néel, University Grenoble Alpes, Grenoble, France.

Santiago Cuesta-López (S)

ICCRAM, University of Burgos, Burgos, Spain.
Advanced Materials and Computational Engineering, ICAMCyL Foundation International Center for Advanced Materials and Raw Materials of Castilla y León, León, Spain.

Nikos Theodorakopoulos (N)

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece.
Fachbereich Physik, Universität Konstanz, Constance, Germany.

Michel Peyrard (M)

Université de Lyon, Ecole Normale Supérieure de Lyon, Laboratoire de Physique, CNRS, UMR 5672, Lyon, France.

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