The xenobiotic receptors PXR and CAR in liver physiology, an update.
Bile acid homeostasis
CAR
Cell proliferation
Energy metabolism
PXR
Xenobiotic receptors
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
04
12
2020
revised:
25
01
2021
accepted:
06
02
2021
pubmed:
19
2
2021
medline:
11
9
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two nuclear receptors that are well-known for their roles in xenobiotic detoxification by regulating the expression of drug-metabolizing enzymes and transporters. In addition to metabolizing drugs and other xenobiotics, the same enzymes and transporters are also responsible for the production and elimination of numerous endogenous chemicals, or endobiotics. Moreover, both PXR and CAR are highly expressed in the liver. As such, it is conceivable that PXR and CAR have major potentials to affect the pathophysiology of the liver by regulating the homeostasis of endobiotics. In recent years, the physiological functions of PXR and CAR in the liver have been extensively studied. Emerging evidence has suggested the roles of PXR and CAR in energy metabolism, bile acid homeostasis, cell proliferation, to name a few. This review summarizes the recent progress in our understanding of the roles of PXR and CAR in liver physiology.
Identifiants
pubmed: 33600998
pii: S0925-4439(21)00034-X
doi: 10.1016/j.bbadis.2021.166101
pmc: PMC8026720
mid: NIHMS1676069
pii:
doi:
Substances chimiques
Constitutive Androstane Receptor
0
Pregnane X Receptor
0
Receptors, Cytoplasmic and Nuclear
0
Xenobiotics
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
166101Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK117370
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES030429
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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