Interferon lambda 4 genotype and pathway in alcoholic hepatitis.

Single nucleotide polymorphisms within the interferon lambda 4 ( In this pilot study, 58 patients with alcoholic hepatitis were genotyped for the Amongst the alcoholic hepatitis patients who died, the IFN negative patients live longer after diagnosis, and also the IFN negative patients tended to have an overall short-term survival benefit compared to IFN lambda positive patients ( The IFN lambda 4 pathway seems involved in the acute disease processes of alcoholic hepatitis and patients without IFN lambda expression seem to have a short-term survival benefit.