Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits.
Black or African American
/ genetics
Aged
Asian People
/ genetics
Blood Pressure
/ genetics
Cross-Sectional Studies
Female
Genome-Wide Association Study
Hispanic or Latino
/ genetics
Humans
Longitudinal Studies
Male
Middle Aged
Quantitative Trait Loci
/ genetics
Quantitative Trait, Heritable
White People
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 02 2021
18 02 2021
Historique:
received:
27
08
2020
accepted:
25
01
2021
entrez:
19
2
2021
pubmed:
20
2
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p = 7.3 × 10
Identifiants
pubmed: 33603002
doi: 10.1038/s41598-021-83450-3
pii: 10.1038/s41598-021-83450-3
pmc: PMC7893038
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4075Subventions
Organisme : Intramural NIH HHS
ID : Z01 HG200362
Pays : United States
Références
Biochemistry. 2003 Jun 24;42(24):7270-82
pubmed: 12809483
Hypertension. 2016 Feb;67(2):349-55
pubmed: 26711733
PLoS Med. 2011 Jun;8(6):e1000440
pubmed: 21695075
Bioinformatics. 2014 May 1;30(9):1266-72
pubmed: 24413527
Am J Epidemiol. 2002 Nov 1;156(9):871-81
pubmed: 12397006
Int J Epidemiol. 2011 Aug;40(4):862-7
pubmed: 20805109
Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012
pubmed: 30445434
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Sci Rep. 2019 Dec 2;9(1):18085
pubmed: 31792241
J Hum Hypertens. 2019 Nov;33(11):775-785
pubmed: 31551569
BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S80
pubmed: 25519409
Am J Epidemiol. 1989 Apr;129(4):687-702
pubmed: 2646917
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Am J Hum Genet. 2013 Sep 5;93(3):545-54
pubmed: 23972371
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8696-701
pubmed: 26124090
Nat Genet. 2019 Jan;51(1):51-62
pubmed: 30578418
J Am Heart Assoc. 2018 Feb 24;7(5):
pubmed: 29478026
Am J Hum Genet. 2018 Mar 01;102(3):375-400
pubmed: 29455858
PLoS One. 2009 Dec 24;4(12):e8460
pubmed: 20041147
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
pubmed: 11125122
Diabetologia. 2011 Apr;54(4):783-8
pubmed: 21188353
BMJ. 2011 Feb 22;342:d643
pubmed: 21343202
Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4
pubmed: 22064851
Hum Hered. 2011;72(2):110-20
pubmed: 21996601
Nat Genet. 2009 Jun;41(6):677-87
pubmed: 19430479
Hypertension. 1995 Mar;25(3):305-13
pubmed: 7875754
BMC Genet. 2017 Dec 08;18(1):105
pubmed: 29221444
Nucleic Acids Res. 2010 Sep;38(16):e164
pubmed: 20601685
Am J Epidemiol. 1969 Dec;90(6):527-35
pubmed: 5362860
J Hum Hypertens. 2000 Jul;14(7):441-5
pubmed: 10918549
Nat Rev Genet. 2019 Sep;20(9):520-535
pubmed: 31235872
Cardiovasc J Afr. 2012 Sep;23(8):456-62
pubmed: 23044502
J Gerontol A Biol Sci Med Sci. 2001 Oct;56(10):M644-9
pubmed: 11584038
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
pubmed: 24194600
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
BMC Proc. 2016 Oct 18;10(Suppl 7):321-327
pubmed: 27980656
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
Nucleic Acids Res. 2015 Jan;43(Database issue):D743-50
pubmed: 25355511
JAMA Intern Med. 2018 Jan 1;178(1):93-99
pubmed: 29204655
Biopreserv Biobank. 2015 Oct;13(5):311-9
pubmed: 26484571
J Med Genet. 2018 Nov;55(11):765-778
pubmed: 30166351
Cell. 2019 Oct 31;179(4):984-1002.e36
pubmed: 31675503
Nat Genet. 2018 Oct;50(10):1412-1425
pubmed: 30224653
J Gerontol A Biol Sci Med Sci. 1997 May;52(3):M177-83
pubmed: 9158560
Am J Hum Genet. 2005 Mar;76(3):427-37
pubmed: 15647995
Database (Oxford). 2018 Jan 1;2018:
pubmed: 30576484
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Nat Genet. 2016 Nov;48(11):1443-1448
pubmed: 27694958
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
J Am Heart Assoc. 2020 Aug 18;9(16):e014513
pubmed: 32805198
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Nature. 2009 Oct 8;461(7265):747-53
pubmed: 19812666
Nat Genet. 2019 Dec;51(12):1749-1755
pubmed: 31768069
Circ Cardiovasc Genet. 2017 Aug;10(4):
pubmed: 28794112
Am J Pathol. 2005 Dec;167(6):1497-509
pubmed: 16314465
Genome Res. 2003 Sep;13(9):2129-41
pubmed: 12952881
Am J Epidemiol. 2018 Jul 1;187(7):1345-1353
pubmed: 29394304
Nat Rev Genet. 2019 Aug;20(8):467-484
pubmed: 31068683
Eur Heart J. 1998 Dec;19(12):1872-8
pubmed: 9886731
Diabetes. 2004 Mar;53(3):838-41
pubmed: 14988271