Nanozymes as Enzyme Inhibitors.
R-chymotrypsin inhibitor
mitochondrial F0F1-ATPase inhibitor
nanozyme
β-galactosidase inhibitor
β-lactamase inhibitor
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
11
2020
accepted:
28
01
2021
entrez:
19
2
2021
pubmed:
20
2
2021
medline:
9
3
2021
Statut:
epublish
Résumé
Nanozyme is a type of nanomaterial with intrinsic enzyme-like activity. Following the discovery of nanozymes in 2007, nanozyme technology has become an emerging field bridging nanotechnology and biology, attracting research from multi-disciplinary areas focused on the design and synthesis of catalytically active nanozymes. However, various types of enzymes can be mimicked by nanomaterials, and our current understanding of nanozymes as enzyme inhibitors is limited. Here, we provide a brief overview of the utility of nanozymes as inhibitors of enzymes, such as R-chymotrypsin (ChT), β-galactosidase (β-Gal), β-lactamase, and mitochondrial F0F1-ATPase, and the mechanisms underlying inhibitory activity. The advantages, challenges and future research directions of nanozymes as enzyme inhibitors for biomedical research are further discussed.
Identifiants
pubmed: 33603373
doi: 10.2147/IJN.S294871
pii: 294871
pmc: PMC7887156
doi:
Substances chimiques
Enzyme Inhibitors
0
Enzymes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1143-1155Informations de copyright
© 2021 Huang et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest in this work.
Références
ACS Appl Mater Interfaces. 2015 May 13;7(18):9898-903
pubmed: 25897818
Adv Appl Microbiol. 2001;49:163-84
pubmed: 11757350
J Am Chem Soc. 2006 Nov 15;128(45):14612-8
pubmed: 17090046
J Chem Inf Model. 2019 Jan 28;59(1):86-97
pubmed: 30408958
Theranostics. 2017 Jul 22;7(13):3207-3227
pubmed: 28900505
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 24;1048:30-37
pubmed: 28192760
Bioconjug Chem. 2019 Aug 21;30(8):2089-2101
pubmed: 31269795
Science. 2008 Jul 18;321(5887):356-61
pubmed: 18635788
J Exp Biol. 2000 Jan;203(Pt 1):9-17
pubmed: 10600668
Int J Nanomedicine. 2018 Aug 23;13:4795-4805
pubmed: 30197515
Nanomedicine. 2010 Jun;6(3):427-41
pubmed: 20056170
Chem Commun (Camb). 2020 Apr 28;56(33):4571-4574
pubmed: 32206768
Trends Biotechnol. 2018 Jan;36(1):15-29
pubmed: 29102240
Curr Opin Lipidol. 2006 Jun;17(3):279-84
pubmed: 16680033
Trends Cell Biol. 2003 Mar;13(3):114-21
pubmed: 12628343
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10661-6
pubmed: 20534582
ACS Nano. 2015 Sep 22;9(9):9097-105
pubmed: 26325486
Methods Enzymol. 2000;305:188-95
pubmed: 10812601
J Med Chem. 2004 Feb 26;47(5):1081-4
pubmed: 14971888
J Clin Invest. 1994 Apr;93(4):1756-64
pubmed: 8163674
J Clin Oncol. 2006 Sep 1;24(25):4054-5
pubmed: 16943522
Bioorg Med Chem Lett. 2008 May 1;18(9):2771-5
pubmed: 18434150
Talanta. 2015 Aug 15;141:47-52
pubmed: 25966379
ACS Biomater Sci Eng. 2018 Mar 12;4(3):1083-1091
pubmed: 33418792
Biosens Bioelectron. 2021 Jan 1;171:112707
pubmed: 33049565
Antimicrob Agents Chemother. 2000 Apr;44(4):891-7
pubmed: 10722487
Lancet Infect Dis. 2011 May;11(5):381-93
pubmed: 21530894
J Am Chem Soc. 2005 Sep 21;127(37):12873-81
pubmed: 16159281
J Am Chem Soc. 2004 Oct 13;126(40):12833-42
pubmed: 15469279
Oncogene. 2002 Nov 21;21(53):8149-57
pubmed: 12444550
J Am Chem Soc. 2001 Dec 19;123(50):12488-94
pubmed: 11741411
Chem Commun (Camb). 2011 Apr 21;47(15):4436-8
pubmed: 21390375
Bioorg Med Chem Lett. 2004 Feb 23;14(4):1027-30
pubmed: 15013016
Molecules. 2020 Jun 02;25(11):
pubmed: 32498444
J Am Chem Soc. 2011 Nov 9;133(44):17524-7
pubmed: 21954932
Biochemistry. 1997 Apr 15;36(15):4576-84
pubmed: 9109667
Curr Opin Chem Biol. 2017 Aug;39:46-53
pubmed: 28605671
Drugs. 2010 Apr 16;70(6):651-79
pubmed: 20394454
Nature. 2009 May 21;459(7245):364-70
pubmed: 19458712
Nat Commun. 2018 Apr 12;9(1):1440
pubmed: 29650959
Cancer Lett. 2004 Nov 25;215(2):129-40
pubmed: 15488631