Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma.


Journal

Sarcoma
ISSN: 1357-714X
Titre abrégé: Sarcoma
Pays: Egypt
ID NLM: 9709257

Informations de publication

Date de publication:
2021
Historique:
received: 19 05 2020
revised: 17 08 2020
accepted: 07 01 2021
entrez: 19 2 2021
pubmed: 20 2 2021
medline: 20 2 2021
Statut: epublish

Résumé

Six cell surface receptors, human epidermal growth factor receptor-2 (Her-2), platelet-derived growth factor receptor- Patient-derived OS cell lines ( All 6 receptors were variably expressed in the majority of cell lines. IR and PDGFR- The six cell surface receptors demonstrated variable expression across the majority of patient-derived OS cell lines tested. Limited prognostic value was offered by IR and PDGFR-

Sections du résumé

BACKGROUND BACKGROUND
Six cell surface receptors, human epidermal growth factor receptor-2 (Her-2), platelet-derived growth factor receptor-
METHODS METHODS
Patient-derived OS cell lines (
RESULTS RESULTS
All 6 receptors were variably expressed in the majority of cell lines. IR and PDGFR-
CONCLUSION CONCLUSIONS
The six cell surface receptors demonstrated variable expression across the majority of patient-derived OS cell lines tested. Limited prognostic value was offered by IR and PDGFR-

Identifiants

pubmed: 33603563
doi: 10.1155/2021/8324348
pmc: PMC7872755
doi:

Types de publication

Journal Article

Langues

eng

Pagination

8324348

Subventions

Organisme : NCI NIH HHS
ID : U10 CA180886
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180899
Pays : United States

Informations de copyright

Copyright © 2021 Yoav Zvi et al.

Déclaration de conflit d'intérêts

The authors have no conflicts of interest to declare.

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Auteurs

Yoav Zvi (Y)

Department of Orthopaedic Surgery, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, NY, USA.

Elif Ugur (E)

The Albert Einstein College of Medicine, Bronx, NY, USA.

Brian Batko (B)

Department of Orthopaedic Surgery, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, NY, USA.

Jonathan Gill (J)

Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.

Michael Roth (M)

Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.

Richard Gorlick (R)

Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.

David Hall (D)

QuadW-COG Childhood Sarcoma Biostatistics and Annotation Office, Children's Oncology Group, Monrovia, CA, USA.

Janet Tingling (J)

Department of Orthopaedic Surgery, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, NY, USA.

Donald A Barkauskas (DA)

QuadW-COG Childhood Sarcoma Biostatistics and Annotation Office, Children's Oncology Group, Monrovia, CA, USA.
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

Jinghang Zhang (J)

Flow Cytometry Core, Albert Einstein College of Medicine, Bronx, NY, USA.

Rui Yang (R)

Department of Orthopaedic Surgery, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, NY, USA.
The Albert Einstein College of Medicine, Bronx, NY, USA.

Bang H Hoang (BH)

Department of Orthopaedic Surgery, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, NY, USA.
The Albert Einstein College of Medicine, Bronx, NY, USA.

David S Geller (DS)

Department of Orthopaedic Surgery, Montefiore Medical Center, The Children's Hospital at Montefiore, Bronx, NY, USA.
The Albert Einstein College of Medicine, Bronx, NY, USA.

Classifications MeSH