T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells.
Animals
Colitis
/ genetics
Immunity, Innate
Inflammatory Bowel Diseases
/ genetics
Intestinal Mucosa
/ immunology
Lymphocytes
/ immunology
Mice
Mice, Knockout
Nuclear Receptor Subfamily 1, Group F, Member 3
/ genetics
Receptors, Interleukin-7
/ genetics
STAT1 Transcription Factor
/ genetics
STAT4 Transcription Factor
/ genetics
T-Box Domain Proteins
/ genetics
ILCs
T-bet
innate lymphoid cells
intestinal inflammation
mucosal homeostasis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
10
2020
accepted:
15
12
2020
entrez:
19
2
2021
pubmed:
20
2
2021
medline:
24
6
2021
Statut:
epublish
Résumé
Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD). However, a role of T-bet-negative ILC3 in driving colitis has also been suggested in mouse models questioning T-bet as a critical factor for IBD. We report here that T-bet deficient mice had a greater cellularity of NKp46-negative ILC3 correlating with enhanced expression of RORγt and IL-7R, but independent of signaling through STAT1 or STAT4. We observed enhanced neutrophilia in the colonic lamina propria (cLP) of these animals, however, we did not detect a greater risk of T-bet-deficient mice to develop spontaneous colitis. Furthermore, by utilizing an
Identifiants
pubmed: 33603753
doi: 10.3389/fimmu.2020.623324
pmc: PMC7884460
doi:
Substances chimiques
Nuclear Receptor Subfamily 1, Group F, Member 3
0
Receptors, Interleukin-7
0
Rorc protein, mouse
0
STAT1 Transcription Factor
0
STAT4 Transcription Factor
0
Stat1 protein, mouse
0
Stat4 protein, mouse
0
T-Box Domain Proteins
0
T-box transcription factor TBX21
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
623324Subventions
Organisme : Medical Research Council
ID : MR/K002996/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT101159
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M003493/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R024812/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 091009
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Schroeder, Meissl, Hromadová, Lo, Neves, Howard, Helmby, Powell, Strobl and Lord.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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