Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional magnetic resonance imaging.
Brain aging
High-field fMRI
Network amplitude
Resting-state fMRI
Sparse graphs
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
07
07
2020
accepted:
20
01
2021
pubmed:
20
2
2021
medline:
1
12
2021
entrez:
19
2
2021
Statut:
ppublish
Résumé
Functional changes in the aging human brain have been previously reported using functional magnetic resonance imaging (fMRI). Earlier resting-state fMRI studies revealed an age-associated weakening of intra-system functional connectivity (FC) and age-associated strengthening of inter-system FC. However, the majority of such FC studies did not investigate the relationship between age and network amplitude, without which correlation-based measures of FC can be challenging to interpret. Consequently, the main aim of this study was to investigate how three primary measures of resting-state fMRI signal-network amplitude, network topography, and inter-network FC-are affected by healthy cognitive aging. We acquired resting-state fMRI data on a 4.7 T scanner for 105 healthy participants representing the entire adult lifespan (18-85 years of age). To study age differences in network structure, we combined ICA-based network decomposition with sparse graphical models. Older adults displayed lower blood-oxygen-level-dependent (BOLD) signal amplitude in all functional systems, with sensorimotor networks showing the largest age differences. Our age comparisons of network topography and inter-network FC demonstrated a substantial amount of age invariance in the brain's functional architecture. Despite architecture similarities, old adults displayed a loss of communication efficiency in our inter-network FC comparisons, driven primarily by the FC reduction in frontal and parietal association cortices. Together, our results provide a comprehensive overview of age effects on fMRI-based FC.
Identifiants
pubmed: 33604746
doi: 10.1007/s00429-021-02226-7
pii: 10.1007/s00429-021-02226-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1098Subventions
Organisme : CIHR
ID : MOP11501
Pays : Canada
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 06186
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 06638
Organisme : CIHR
ID : MOP11501
Pays : Canada
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