An Analysis for Adulteration and Contamination of Over-the-Counter Weight-Loss Products.
adulteration
complementary medicine
contamination
heavy metal
patient safety
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
18 Feb 2021
18 Feb 2021
Historique:
received:
14
10
2020
accepted:
26
01
2021
entrez:
19
2
2021
pubmed:
20
2
2021
medline:
26
3
2021
Statut:
epublish
Résumé
Six Australian and five overseas complementary medicines (CM) and meal replacement shake products were analysed for potential adulteration with two common active pharmaceutical ingredients, caffeine and sibutramine, using thin-layer chromatography and mass spectrometry. The declared amount of caffeine in each product was also reviewed. Finally, the products were examined for heavy metal contamination using inductively coupled plasma-mass spectrometry. The results showed that there was no detected adulteration of either caffeine (for those products that did not list caffeine as an ingredient) or sibutramine in the 11 products; however, based on the product labels, one Australian and one overseas (two in total) CM product contained more than the maximum daily safety limit (400 mg) of caffeine. Potentially excessive lead and/or chromium was detected in six products, including four Australian products and two products purchased online. One Australian CM product appeared to contain these heavy metals at concentrations at, or exceeding, the safety limits specified in the United States Pharmacopeia or set by the World Health Organization. The overconsumption of caffeine and heavy metals has the potential of causing significant health effects in consumers.
Identifiants
pubmed: 33604777
doi: 10.1208/s12249-021-01946-7
pii: 10.1208/s12249-021-01946-7
doi:
Substances chimiques
Cyclobutanes
0
Metals, Heavy
0
Nonprescription Drugs
0
Caffeine
3G6A5W338E
sibutramine
WV5EC51866
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
78Références
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