Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life.
Chemotherapy
Quality of life
Taste alterations
Taste disorders
Taxane
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
09
09
2020
accepted:
09
02
2021
pubmed:
20
2
2021
medline:
9
10
2021
entrez:
19
2
2021
Statut:
ppublish
Résumé
There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL), and adverse events. This cross-sectional study evaluated 100 patients receiving paclitaxel, docetaxel, or nab-paclitaxel as monotherapy or combination therapy. Taste alterations were evaluated using taste recognition thresholds and severity and symptom scales. Taste recognition thresholds, symptoms, appetite, weight, and adverse events were compared between patients with and without taste alterations, and logistic regression analysis was performed to identify risk factors. Of the 100 patients, 59% reported taste alterations. We found significantly elevated taste recognition thresholds (hypogeusia) for sweet, sour, and bitter tastes in the taste alteration group receiving nab-paclitaxel (p = 0.022, 0.020, and 0.039, respectively). The taste alteration group reported general taste alterations, decline in basic taste, and decreased appetite. Neither weight nor QOL was associated with taste alterations. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were significantly associated with taste alterations. Almost 60% of patients receiving taxane-based regimens, especially docetaxel, reported taste alterations. Taste alteration affected the patient's appetite but did not affect the weight or QOL. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were independent risk factors for taste alterations.
Identifiants
pubmed: 33604787
doi: 10.1007/s00520-021-06066-3
pii: 10.1007/s00520-021-06066-3
pmc: PMC8295069
doi:
Substances chimiques
Taxoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5103-5114Informations de copyright
© 2021. The Author(s).
Références
Wagland R, Richardson A, Ewings S, Armes J, Lennan E, Hankins M, Griffiths P (2016) Prevalence of cancer chemotherapy-related problems, their relation to health-related quality of life and associated supportive care: a cross-sectional survey. Supportive Care in Cancer 12:4901–4911. https://doi.org/10.1007/s00520-016-3346-4
doi: 10.1007/s00520-016-3346-4
Williams AR, Mowlazadeh B, Sisler L, Williams PD (2015) Self-reported assessment of symptoms and self-care within a cohort of U.S. veterans during outpatient care for cancer. Clinical Journal of Oncology Nursing 19(5):595–602. https://doi.org/10.1188/15.cjon.595-602
doi: 10.1188/15.cjon.595-602
Rahnama M, Madej-Czerwonka B, Jastrzebska-Jamrogiewicz I, Jamrogiewicz R (2015) Analysis of the influence of parenteral cancer chemotherapy on the health condition of oral mucosa. Contemporary Oncology (Poznan, Poland) 19(1):77–82. https://doi.org/10.5114/wo.2014.45291
doi: 10.5114/wo.2014.45291
Bernhardson BM, Tishelman C, Rutqvist LE (2007) Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. Journal of Pain and Symptom Management 34(4):403–412. https://doi.org/10.1016/j.jpainsymman.2006.12.010
doi: 10.1016/j.jpainsymman.2006.12.010
Turcott JG, Juarez-Hernandez E, De la Torre-Vallejo M, Sanchez-Lara K, Luvian-Morales J, Arrieta O (2016) Value: changes in the detection and recognition thresholds of three basic tastes in lung cancer patients receiving cisplatin and paclitaxel and its association with nutritional and quality of life parameters. Nutrition and Cancer 68(2):241–249. https://doi.org/10.1080/01635581.2016.1144075
doi: 10.1080/01635581.2016.1144075
Boltong A, Aranda S, Keast R, Wynne R, Francis PA, Chirgwin J, Gough K (2014) A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes. PloS One 9(7):e103512. https://doi.org/10.1371/journal.pone.0103512
doi: 10.1371/journal.pone.0103512
pubmed: 4117507
pmcid: 4117507
Rehwaldt M, Wickham R, Purl S, Tariman J, Blendowski C, Shott S, Lappe M (2009) Self-care strategies to cope with taste changes after chemotherapy. Oncology Nursing Forum 36(2):E47–E56. https://doi.org/10.1188/09.onf.e47-e56
doi: 10.1188/09.onf.e47-e56
pubmed: 2893729
pmcid: 2893729
Zabernigg A, Gamper E, Giesinger JM, Rumpold G, Kemmler G, Gattringer K, Sperner-Unterweger B, Holzner B (2010) Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist 15(8):913–920. https://doi.org/10.1634/theoncologist.2009-0333
doi: 10.1634/theoncologist.2009-0333
pubmed: 3228016
pmcid: 3228016
McGreevy J, Orrevall Y, Belqaid K, Wismer W, Tishelman C, Bernhardson BM (2014) Characteristics of taste and smell alterations reported by patients after starting treatment for lung cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 22(10):2635–2644. https://doi.org/10.1007/s00520-014-2215-2
doi: 10.1007/s00520-014-2215-2
Coa KI, Epstein JB, Ettinger D, Jatoi A, McManus K, Platek ME, Price W, Stewart M, Teknos TN, Moskowitz B (2015) The impact of cancer treatment on the diets and food preferences of patients receiving outpatient treatment. Nutrition and Cancer 67(2):339–353. https://doi.org/10.1080/01635581.2015.990577
doi: 10.1080/01635581.2015.990577
pubmed: 4353259
pmcid: 4353259
Sanchez-Lara K, Sosa-Sanchez R, Green-Renner D, Rodriguez C, Laviano A, Motola-Kuba D, Arrieta O (2010) Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy. Nutrition Journal 9:15. https://doi.org/10.1186/1475-2891-9-15
doi: 10.1186/1475-2891-9-15
pubmed: 2858711
pmcid: 2858711
Ravasco P (2005) Aspects of taste and compliance in patients with cancer. European Journal of Oncology Nursing : the official journal of European Oncology Nursing Society 9(Suppl 2):S84–S91. https://doi.org/10.1016/j.ejon.2005.09.003
doi: 10.1016/j.ejon.2005.09.003
Boltong A, Keast R, Aranda S (2012) Experiences and consequences of altered taste, flavour and food hedonics during chemotherapy treatment. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20(11):2765–2774. https://doi.org/10.1007/s00520-012-1398-7
doi: 10.1007/s00520-012-1398-7
Heckmann JG, Heckmann SM, Lang CJ, Hummel T (2003) Neurological aspects of taste disorders. Archives of Neurology 60(5):667–671. https://doi.org/10.1001/archneur.60.5.667
doi: 10.1001/archneur.60.5.667
McLaughlin L, Mahon SM (2012) Understanding taste dysfunction in patients with cancer. Clinical Journal of Oncology Nursing 16(2):171–178. https://doi.org/10.1188/12.cjon.171-178
doi: 10.1188/12.cjon.171-178
Boyce JM, Shone GR (2006) Effects of ageing on smell and taste. Postgraduate Medical Journal 82(966):239–241. https://doi.org/10.1136/pgmj.2005.039453
doi: 10.1136/pgmj.2005.039453
pubmed: 2579627
pmcid: 2579627
Vennemann MM, Hummel T, Berger K (2008) The association between smoking and smell and taste impairment in the general population. Journal of Neurology 255(8):1121–1126. https://doi.org/10.1007/s00415-008-0807-9
doi: 10.1007/s00415-008-0807-9
Ponticelli E, Clari M, Frigerio S, De Clemente A, Bergese I, Scavino E, Bernardini A, Sacerdote C (2017) Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: a cross-sectional study. European Journal of Cancer Care 26(2). https://doi.org/10.1111/ecc.12633
van Oort S, Kramer E, de Groot JW, Visser O (2018) Taste alterations and cancer treatment. Current Opinion in Supportive and Palliative Care 12(2):162–167. https://doi.org/10.1097/spc.0000000000000346
doi: 10.1097/spc.0000000000000346
Gamper EM, Zabernigg A, Wintner LM, Giesinger JM, Oberguggenberger A, Kemmler G, Sperner-Unterweger B, Holzner B (2012) Coming to your senses: detecting taste and smell alterations in chemotherapy patients. A systematic review. Journal of Pain and Symptom Management 44(6):880–895. https://doi.org/10.1016/j.jpainsymman.2011.11.011
doi: 10.1016/j.jpainsymman.2011.11.011
Amezaga J, Alfaro B, Rios Y, Larraioz A, Ugartemendia G, Urruticoechea A, Tueros I (2018) Assessing taste and smell alterations in cancer patients undergoing chemotherapy according to treatment. https://doi.org/10.1007/s00520-018-4277-z
Nishijima S, Yanase T, Tsuneki I, Tamura M, Kurabayashi T (2013) Examination of the taste disorder associated with gynecological cancer chemotherapy. Gynecologic Oncology 131(3):674–678. https://doi.org/10.1016/j.ygyno.2013.09.015
doi: 10.1016/j.ygyno.2013.09.015
Tomita H, Ikeda M, Okuda Y (1986) Basis and practice of clinical taste examinations. Auris, Nasus, Larynx 13(Suppl 1):S1–S15. https://doi.org/10.1016/s0385-8146(86)80029-3
Basch E, Pugh SL, Dueck AC, Mitchell SA, Berk L, Fogh S, Rogak LJ, Gatewood M, Reeve BB, Mendoza TR, O’Mara AM, Denicoff AM, Minasian LM, Bennett AV, Setser A, Schrag D, Roof K, Moore JK, Gergel T, Stephans K, Rimner A, DeNittis A, Bruner DW (2017) Feasibility of patient reporting of symptomatic adverse events via the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE) in a chemoradiotherapy cooperative group multicenter clinical trial. International Journal of Radiation Oncology, Biology, Physics 98(2):409–418. https://doi.org/10.1016/j.ijrobp.2017.02.002
doi: 10.1016/j.ijrobp.2017.02.002
pubmed: 5557037
pmcid: 5557037
Kawaguchi T, Azuma K, Sano M, Kim S, Kawahara Y, Sano Y, Shimodaira T, Ishibashi K, Miyaji T, Basch E, Yamaguchi T (2017) The Japanese version of the National Cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE): psychometric validation and discordance between clinician and patient assessments of adverse events. Journal of Patient-Reported Outcomes 2(1):2. https://doi.org/10.1186/s41687-017-0022-5
doi: 10.1186/s41687-017-0022-5
Kano T, Kanda K (2013) Development and validation of a chemotherapy-induced taste alteration scale. Oncology Nursing Forum 40(2):E79–E85. https://doi.org/10.1188/13.onf.e79-e85
doi: 10.1188/13.onf.e79-e85
Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, Silberman M, Yellen SB, Winicour P, Brannon J et al (1993) The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 11(3):570–579. https://doi.org/10.1200/jco.1993.11.3.570
doi: 10.1200/jco.1993.11.3.570
Fumimoto H, Kobayashi K, Chang CH, Eremenco S, Fujiki Y, Uemura S, Ohashi Y, Kudoh S (2001) Cross-cultural validation of an international questionnaire, the General Measure of the Functional Assessment of Cancer Therapy scale (FACT-G), for Japanese. Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation 10(8):701–709
doi: 10.1023/A:1013851216181
Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SL, Walters EE, Zaslavsky AM (2002) Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychological Medicine 32(6):959–976
doi: 10.1017/S0033291702006074
Furukawa TA, Kawakami N, Saitoh M, Ono Y, Nakane Y, Nakamura Y, Tachimori H, Iwata N, Uda H, Nakane H, Watanabe M, Naganuma Y, Hata Y, Kobayashi M, Miyake Y, Takeshima T, Kikkawa T (2008) The performance of the Japanese version of the K6 and K10 in the World Mental Health Survey Japan. International Journal of Methods in Psychiatric Research 17(3):152–158. https://doi.org/10.1002/mpr.257
doi: 10.1002/mpr.257
pubmed: 6878390
pmcid: 6878390
Campagna S, Gonella S, Sperlinga R, Giuliano PL, Marchese R, Pedersini R, Berchialla P, Dimonte V (2018) Prevalence, severity, and self-reported characteristics of taste alterations in patients receiving chemotherapy. Oncology Nursing Forum 45(3):342–353. https://doi.org/10.1188/18.onf.342-353
doi: 10.1188/18.onf.342-353
Speck RM, DeMichele A, Farrar JT, Hennessy S, Mao JJ, Stineman MG, Barg FK (2013) Taste alteration in breast cancer patients treated with taxane chemotherapy: experience, effect, and coping strategies. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 21(2):549–555. https://doi.org/10.1007/s00520-012-1551-3
doi: 10.1007/s00520-012-1551-3
Kuba S, Fujiyama R, Yamanouchi K, Morita M, Sakimura C, Hatachi T, Matsumoto M, Yano H, Takatsuki M, Hayashida N, Nagayasu T, Eguchi S (2018) Awareness of dysgeusia and gustatory tests in patients undergoing chemotherapy for breast cancer. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. 26:3883–3889. https://doi.org/10.1007/s00520-018-4256-4
doi: 10.1007/s00520-018-4256-4
Epstein JB, Smutzer G, Doty RL (2016) Understanding the impact of taste changes in oncology care. Supportive Care in Cancer : official journal of the Multinational Association of Supportive Care in Cancer 24(4):1917–1931. https://doi.org/10.1007/s00520-016-3083-8
doi: 10.1007/s00520-016-3083-8
Tang CC, Draucker C, Tejani M, Von Ah D (2018) Symptom experiences in patients with advanced pancreatic cancer as reported during healthcare encounters. European Journal of Cancer Care 27(3):e12838. https://doi.org/10.1111/ecc.12838
doi: 10.1111/ecc.12838
Mukherjee N, Carroll BL, Spees JL, Delay ER (2013) Pre-treatment with amifostine protects against cyclophosphamide-induced disruption of taste in mice. PloS one 8(4):e61607. https://doi.org/10.1371/journal.pone.0061607
doi: 10.1371/journal.pone.0061607
pubmed: 3634019
pmcid: 3634019
de Vries RMW YC, van den Berg MMGA, de Graaf C, Boesveldt S (2018) Altered food preferences and chemosensory perception during chemotherapy in breast cancer patients : a longitudinal comparison with healthy controls. Food Quality and Preference 63:135–143. https://doi.org/10.1371/journal.pone.0185473
doi: 10.1371/journal.pone.0185473
Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E, Potter C, Blendowski C (1999) Taste changes experienced by patients receiving chemotherapy. Oncology Nursing Forum 26(4):697–706
Bernhardson BM, Tishelman C, Rutqvist LE (2008) Self-reported taste and smell changes during cancer chemotherapy. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 16(3):275–283. https://doi.org/10.1007/s00520-007-0319-7
doi: 10.1007/s00520-007-0319-7
Okada N, Hanafusa T, Abe S, Sato C, Nakamura T, Teraoka K, Abe M, Kawazoe K, Ishizawa K (2016) Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 24(9):3979–3985. https://doi.org/10.1007/s00520-016-3244-9
doi: 10.1007/s00520-016-3244-9
Bernhardson BM, Tishelman C, Rutqvist LE (2009) Taste and smell changes in patients receiving cancer chemotherapy: distress, impact on daily life, and self-care strategies. Cancer Nursing 32(1):45–54. https://doi.org/10.1097/01.ncc.0000343368.06247.74
doi: 10.1097/01.ncc.0000343368.06247.74