Trunk Skeletal Muscle Changes on CT with Long-Duration Spaceflight.
Astronaut
Computed tomography
Cross-sectional area
Microgravity
Muscle atrophy
Muscle attenuation
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
12
10
2020
accepted:
02
02
2021
pubmed:
20
2
2021
medline:
6
11
2021
entrez:
19
2
2021
Statut:
ppublish
Résumé
Astronauts exposed to microgravity for extended time are susceptible to trunk muscle atrophy, which may compromise strength and function on mission and after return. This study investigates changes in trunk skeletal muscle size and composition using computed tomography (CT) and dual-energy X-ray absorptiometry (DXA) among 16 crewmembers (1 female, 15 male) on 4-6 month missions. Muscle cross-sectional area and muscle attenuation were measured using abdominal CT scans at pre-flight, post-flight return, 1 year post-flight, and 2-4 years post-flight. Longitudinal muscle changes were analyzed using mixed models. In six crewmembers, CT and DXA data were used to calculate subject height-normalized skeletal muscle indices. Changes in these indices were analyzed using paired t-tests and compared by imaging modality using Pearson correlations. Trunk muscle area decreased at post-flight return (- 4.7 ± 1.1%, p < 0.001) and recovered to pre-flight values at 1-4 years post-flight. Muscle attenuation changes were not significant. Skeletal muscle index from CT decreased (- 5.2 ± 1.0%, p = 0.004) while appendicular skeletal muscle index from DXA did not change significantly. In summary, trunk muscle atrophies with long-duration microgravity exposure but recovers to pre-flight values within 1-4 years. The CT measures highlight size decreases not detected with DXA, emphasizing the importance of advanced imaging modalities in assessing muscle health with spaceflight.
Identifiants
pubmed: 33604800
doi: 10.1007/s10439-021-02745-8
pii: 10.1007/s10439-021-02745-8
pmc: PMC8207531
mid: NIHMS1710724
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1257-1266Subventions
Organisme : NIA NIH HHS
ID : F31 AG069414
Pays : United States
Organisme : NIA NIH HHS
ID : K25 AG058804
Pays : United States
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