A Case of Whipple Disease With Cutaneous Manifestations.
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Sep 2021
01 Sep 2021
Historique:
pubmed:
20
2
2021
medline:
4
1
2022
entrez:
19
2
2021
Statut:
ppublish
Résumé
Whipple disease (WD) is a rare bacterial infectious disease that is classically characterized by years of arthralgia, followed by malabsorption, diarrhea, and weight loss. However, WD may manifest in virtually any organ system, and patients with WD rarely develop subcutaneous erythema nodosum-like lesions. We report a case of a 51-year-old man diagnosed with WD who subsequently developed widely distributed erythematous subcutaneous nodules after 5 months of antibiotic therapy.
Identifiants
pubmed: 33606378
doi: 10.1097/DAD.0000000000001925
pii: 00000372-202109000-00019
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Inflammatory Agents
0
Prednisone
VB0R961HZT
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e104-e106Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Moos V, Schneider T. Changing paradigms in Whipple's disease and infection with tropheryma whipplei. Eur J Clin Microbiol Infect Dis. 2011;30:1151–1158.
Marth T, Moos V, Müller C, et al. Tropheryma whipplei infection and Whipple's disease. Lancet Infect Dis. 2016;16:e13–e22.
Fenollar F, Laouira S, Lepidi H, et al. Value of tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening. Clin Infect Dis. 2008;47:659–667.
Schneider T, Moos V, Loddenkemper C, et al. Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis. 2008;8:179–190.
Schaller J, Carlson JA. Erythema nodosum-like lesions in treated Whipple's disease: signs of immune reconstitution inflammatory syndrome. J Am Acad Dermatol. 2009;60:277–288.
Canal L, Fuente D, Rodriguez-Moreno J, et al. Specific cutaneous involvement in Whipple disease. Am J Dermatopathol. 2014;36:344–346.
Tarroch X, Vives P, Salas A, et al. Subcutaneous nodules in Whipple's disease. J Cutan Pathol. 2001;28:368–370.
Balestrieri GP, Villanacci V, Battocchio S, et al. Cutaneous involvement in Whipple's disease. Br J Dermatol. 1996;135:666–668.
Kwee D, Fields JP, King LE. Subcutaneous Whipple's disease. J Am Acad Dermatol. 1987;16:188–190.
Vayssade M, Tournadre A, D'Incan M, et al. Immune reconstitution inflammatory syndrome during treatment of Whipple's disease. Jt Bone Spine Rev Rhum. 2015;82:122–124.
Lagier JC, Fenollar F, Lepidi H, et al. Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide. J Infect. 2010;60:79–82.
Keita AK, Bassene H, Tall A, et al. Tropheryma whipplei: a common bacterium in rural Senegal. PLoS Negl Trop Dis. 2011;5:e1403.
Fenollar F, Lagier JC, Raoult D. Tropheryma whipplei and Whipple's disease. J Infect. 2014;69:103–112.
Feurle GE, Moos V, Schinnerling K, et al. The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. Ann Intern Med. 2010;153:710–717.
Biagi F, Trotta L, Di Stefano M, et al. Previous immunosuppressive therapy is a risk factor for immune reconstitution inflammatory syndrome in Whipple's disease. Dig Liver Dis. 2012;44:880–882.
Wechsler J, Ingen-Housz-Oro S, Socolovschi C, et al. Pseudo-Whipple disease cutaneous lesions. Am J Dermatopathol. 2016;38:934–935.