Household finished flooring and soil-transmitted helminth and Giardia infections among children in rural Bangladesh and Kenya: a prospective cohort study.
Adolescent
Bangladesh
/ epidemiology
Child
Child, Preschool
Developing Countries
Enzyme-Linked Immunosorbent Assay
Feces
/ parasitology
Female
Floors and Floorcoverings
/ methods
Giardiasis
/ epidemiology
Helminthiasis
/ epidemiology
Housing
Humans
Kenya
/ epidemiology
Male
Prevalence
Prospective Studies
Real-Time Polymerase Chain Reaction
Rural Population
Soil
/ parasitology
Journal
The Lancet. Global health
ISSN: 2214-109X
Titre abrégé: Lancet Glob Health
Pays: England
ID NLM: 101613665
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
24
06
2020
revised:
20
11
2020
accepted:
30
11
2020
pubmed:
20
2
2021
medline:
10
3
2021
entrez:
19
2
2021
Statut:
ppublish
Résumé
Soil-transmitted helminths and Giardia duodenalis are responsible for a large burden of disease globally. In low-resource settings, household finished floors (eg, concrete floors) might reduce transmission of soil-transmitted helminths and G duodenalis. In a prospective cohort of children nested within two randomised trials in rural Bangladesh and Kenya, we estimated associations between household finished flooring and soil-transmitted helminths and G duodenalis prevalence. In 2015-16, we collected stool samples from children aged 2-16 years in rural Bangladesh and Kenya. We detected soil-transmitted helminth infection using quantitative PCR (qPCR; Bangladesh n=2800; Kenya n=3094), and G duodenalis using qPCR in Bangladesh (n=6894) and ELISA in Kenya (n=8899). We estimated adjusted prevalence ratios (aPRs) using log-linear models adjusted for potential confounders. 7187 (92·2%) of 7795 children in Bangladesh and 9077 (93·7%) of 9686 children in Kenya provided stool specimens that were analysed by qPCR. At enrolment, 691 (10%) households in Bangladesh and 471 (5%) households in Kenya had finished floors. In both countries, household finished flooring was associated with lower Ascaris lumbricoides prevalence (Bangladesh aPR 0·33, 95% CI 0·14-0·78; Kenya 0·62, 0·39-0·98) and any soil-transmitted helminths (Bangladesh 0·73, 0·52-1·01; Kenya 0·57, 0·37-0·88). Household finished floors were also associated with lower Necator americanus prevalence in Bangladesh (0·52, 0·29-0·94) and G duodenalis prevalence in both countries (Bangladesh 0·78, 0·64-0·95; Kenya 0·82, 0·70-0·97). In low-resource settings, living in households with finished floors over a 2-year period was associated with lower prevalence of G duodenalis and some soil-transmitted helminths in children. Bill & Melinda Gates Foundation and Task Force for Global Health.
Sections du résumé
BACKGROUND
Soil-transmitted helminths and Giardia duodenalis are responsible for a large burden of disease globally. In low-resource settings, household finished floors (eg, concrete floors) might reduce transmission of soil-transmitted helminths and G duodenalis.
METHODS
In a prospective cohort of children nested within two randomised trials in rural Bangladesh and Kenya, we estimated associations between household finished flooring and soil-transmitted helminths and G duodenalis prevalence. In 2015-16, we collected stool samples from children aged 2-16 years in rural Bangladesh and Kenya. We detected soil-transmitted helminth infection using quantitative PCR (qPCR; Bangladesh n=2800; Kenya n=3094), and G duodenalis using qPCR in Bangladesh (n=6894) and ELISA in Kenya (n=8899). We estimated adjusted prevalence ratios (aPRs) using log-linear models adjusted for potential confounders.
FINDINGS
7187 (92·2%) of 7795 children in Bangladesh and 9077 (93·7%) of 9686 children in Kenya provided stool specimens that were analysed by qPCR. At enrolment, 691 (10%) households in Bangladesh and 471 (5%) households in Kenya had finished floors. In both countries, household finished flooring was associated with lower Ascaris lumbricoides prevalence (Bangladesh aPR 0·33, 95% CI 0·14-0·78; Kenya 0·62, 0·39-0·98) and any soil-transmitted helminths (Bangladesh 0·73, 0·52-1·01; Kenya 0·57, 0·37-0·88). Household finished floors were also associated with lower Necator americanus prevalence in Bangladesh (0·52, 0·29-0·94) and G duodenalis prevalence in both countries (Bangladesh 0·78, 0·64-0·95; Kenya 0·82, 0·70-0·97).
INTERPRETATION
In low-resource settings, living in households with finished floors over a 2-year period was associated with lower prevalence of G duodenalis and some soil-transmitted helminths in children.
FUNDING
Bill & Melinda Gates Foundation and Task Force for Global Health.
Identifiants
pubmed: 33607029
pii: S2214-109X(20)30523-4
doi: 10.1016/S2214-109X(20)30523-4
pmc: PMC7900607
pii:
doi:
Substances chimiques
Soil
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e301-e308Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
Références
Rev Inst Med Trop Sao Paulo. 1972 Nov-Dec;14(6):397-400
pubmed: 4675644
Lancet Glob Health. 2018 Jun;6(6):e616-e617
pubmed: 29706562
Lancet Glob Health. 2018 Mar;6(3):e302-e315
pubmed: 29396217
J Trop Med Hyg. 1992 Apr;95(2):95-103
pubmed: 1560490
Stat Appl Genet Mol Biol. 2007;6:Article25
pubmed: 17910531
PLoS Negl Trop Dis. 2015 Dec 01;9(12):e0004256
pubmed: 26624994
Clin Infect Dis. 2018 Oct 30;67(10):1515-1522
pubmed: 29669039
Trans R Soc Trop Med Hyg. 1994 Sep-Oct;88(5):527-30
pubmed: 7992327
PLoS Negl Trop Dis. 2020 Apr 24;14(4):e0008087
pubmed: 32330127
Lancet Glob Health. 2018 Mar;6(3):e316-e329
pubmed: 29396219
BMJ. 2017 Sep 25;358:j4307
pubmed: 28947636
Int J Environ Res Public Health. 2016 Jun 04;13(6):
pubmed: 27271651
Adv Parasitol. 2006;62:221-61
pubmed: 16647972
PLoS Negl Trop Dis. 2012;6(5):e1621
pubmed: 22590656
One Health. 2019 Nov 28;9:100116
pubmed: 31872035
Rev Inst Med Trop Sao Paulo. 2007 Jul-Aug;49(4):251-5
pubmed: 17823756
PLoS One. 2015 Dec 03;10(12):e0142927
pubmed: 26632843
PLoS One. 2016 Jun 24;11(6):e0157780
pubmed: 27341102
Am J Public Health. 2009 Nov;99 Suppl 3:S681-92
pubmed: 19890174
Parasitology. 2015 Oct;142(12):1543-54
pubmed: 26302902
Am J Trop Med Hyg. 2016 Sep 7;95(3):508-513
pubmed: 27481053
Lancet. 2017 Jan 21;389(10066):287-297
pubmed: 27979381
PLoS Negl Trop Dis. 2019 May 3;13(5):e0007323
pubmed: 31050672
PLoS Med. 2019 Jun 26;16(6):e1002841
pubmed: 31242190
Am J Epidemiol. 2011 Oct 15;174(8):984-92
pubmed: 21841157
PLoS Negl Trop Dis. 2019 Aug 9;13(8):e0007427
pubmed: 31398204
Ann Intern Med. 2017 Aug 15;167(4):268-274
pubmed: 28693043
Parasit Vectors. 2016 Jan 27;9:38
pubmed: 26813411