Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.
Autophagy
Methionine chelated Zn
Molecular nutrition
Nutrient metabolism
mTOR pathway
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
17
11
2020
accepted:
06
02
2021
pubmed:
20
2
2021
medline:
12
10
2021
entrez:
19
2
2021
Statut:
ppublish
Résumé
Amino acid-chelated zinc (Zn) can increase anabolism of animals. However, the underlying mechanisms are unclear. We aimed to examine how autophagy impact anabolism following a diet containing methionine-chelated Zn (ZnMet) compared with inorganic Zn (ZnSO Yellow catfish (weight: 4.02 ± 0.08 g) were fed two diets containing ZnSO ZnMet up-regulated the expression of genes associated with anabolism and autophagy. The differentially expressed genes (DEG) analysis indicated that both mTOR and autophagy pathways were activated. ZnMet-induced activation of autophagy was mTOR-independent. In this process, forkhead box class O was deacetylated and activated, and induced autophagy, which provided substrates for energy generation. ZnMet increased anabolism through integrating mTOR signal and autophagy pathway in yellow catfish. The present study unravels a novel mechanism for amino acid-chelated minerals improving anabolism.
Sections du résumé
BACKGROUND
BACKGROUND
Amino acid-chelated zinc (Zn) can increase anabolism of animals. However, the underlying mechanisms are unclear. We aimed to examine how autophagy impact anabolism following a diet containing methionine-chelated Zn (ZnMet) compared with inorganic Zn (ZnSO
METHODS
METHODS
Yellow catfish (weight: 4.02 ± 0.08 g) were fed two diets containing ZnSO
RESULTS
RESULTS
ZnMet up-regulated the expression of genes associated with anabolism and autophagy. The differentially expressed genes (DEG) analysis indicated that both mTOR and autophagy pathways were activated. ZnMet-induced activation of autophagy was mTOR-independent. In this process, forkhead box class O was deacetylated and activated, and induced autophagy, which provided substrates for energy generation.
CONCLUSIONS
CONCLUSIONS
ZnMet increased anabolism through integrating mTOR signal and autophagy pathway in yellow catfish. The present study unravels a novel mechanism for amino acid-chelated minerals improving anabolism.
Identifiants
pubmed: 33607355
pii: S0946-672X(21)00022-5
doi: 10.1016/j.jtemb.2021.126732
pii:
doi:
Substances chimiques
Chelating Agents
0
Organometallic Compounds
0
Methionine
AE28F7PNPL
TOR Serine-Threonine Kinases
EC 2.7.11.1
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126732Informations de copyright
Copyright © 2021 Elsevier GmbH. All rights reserved.