Microbiome and pancreatic ductal adenocarcinoma.

Carcinoma, Pancreatic Ductal Humans Microbiota Pancreatic Neoplasms Tumor Microenvironment Pancreatic Neoplasms
Dysbiosis Fungi Intratumor bacteria Microbiota Pancreatic cancer

Journal

Clinics and research in hepatology and gastroenterology
ISSN: 2210-741X
Titre abrégé: Clin Res Hepatol Gastroenterol
Pays: France
ID NLM: 101553659

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 31 10 2020
accepted: 24 11 2020
pubmed: 20 2 2021
medline: 15 12 2021
entrez: 19 2 2021
Statut: ppublish

Résumé

Pancreatic ductal adenocarcinoma (PDAC) incidence and related-deaths are increasing worldwide. PDAC is characterized by poor prognosis due to late diagnosis, high metastatic capacity and resistance to therapy. This is partially due to its specific microenvironment, where the stroma is prominent over tumor cells. Besides the oral and gut microbiota, the intratumor microbiome, i.e. the bacterial and fungal microorganisms present within the tumor, was recently introduced as a new partner of the tumor microenvironment of PDAC modulating pancreatic carcinogenesis, intratumor immune infiltrates, and response to chemotherapy. In this review, we propose an overview of current knowledge about the roles of bacteria and fungi in PDAC development and biology, and discuss potential therapeutic implications.

Identifiants

DOI: 10.1016/j.clinre.2020.101589 PMID: 33607375
pubmed: 33607375
pii: S2210-7401(20)30355-7
doi: 10.1016/j.clinre.2020.101589
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101589

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Auteurs

Annemilaï Tijeras-Raballand (A)

OncoMEGA, Lamorlaye, France.

Marc Hilmi (M)

OncoMEGA, Lamorlaye, France; Medical Oncology Department, Curie Institute, Versailles Saint-Quentin University (UVQ), Paris Saclay University, Saint-Cloud, France.

Lucile Astorgues-Xerri (L)

OncoMEGA, Lamorlaye, France.

Rémy Nicolle (R)

OncoMEGA, Lamorlaye, France; Carte d'Identité des Tumeurs (Tumors Identity Card), La Ligue Contre le Cancer, Paris, France.

Ivan Bièche (I)

Pharmacogenomic Unit, Genetic Department, Curie Institute, Paris, France.

Cindy Neuzillet (C)

OncoMEGA, Lamorlaye, France; Medical Oncology Department, Curie Institute, Versailles Saint-Quentin University (UVQ), Paris Saclay University, Saint-Cloud, France. Electronic address: cindy.neuzillet@curie.fr.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Microbiome and pancreatic ductal adenocarcinoma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Microbiome and pancreatic ductal adenocarcinoma.
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome and pancreatic ductal adenocarcinoma.
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Microbiome and pancreatic ductal adenocarcinoma.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Microbiome and pancreatic ductal adenocarcinoma.
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Microbiome and pancreatic ductal adenocarcinoma.