Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in

Animals Clostridium histolyticum / physiology Glucokinase / genetics Glucose / genetics Glucose Tolerance Test Immunohistochemistry Insulin-Secreting Cells / metabolism Metabolome / genetics Mice Real-Time Polymerase Chain Reaction

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
04 2021
Historique:
received: 27 08 2020
accepted: 22 01 2021
pubmed: 21 2 2021
medline: 24 8 2021
entrez: 20 2 2021
Statut: ppublish

Résumé

Efficacy of glucokinase activation on glycemic control is limited to a short-term period. One reason might be related to excess glucose signaling by glucokinase activation toward β-cells. In this study, we investigated the effect of glucokinase haploinsufficiency on glucose tolerance as well as β-cell function and mass using a mouse model of type 2 diabetes. Our results showed that in

Identifiants

DOI: 10.2337/db20-0881 PMID: 33608422
pubmed: 33608422
pii: db20-0881
doi: 10.2337/db20-0881
doi:

Substances chimiques

Glucokinase EC 2.7.1.2
Glucose IY9XDZ35W2

Banques de données

figshare
['10.2337/figshare.13626674']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

917-931

Informations de copyright

© 2021 by the American Diabetes Association.

Auteurs

Kazuno Omori (K)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Akinobu Nakamura (A)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan akinbo@tim.hi-ho.ne.jp.
ORCID: 0000-0002-8192-0006

Hideaki Miyoshi (H)

Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine Hokkaido University, Sapporo, Japan.

Yuki Yamauchi (Y)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Shinichiro Kawata (S)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Kiyohiko Takahashi (K)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Naoyuki Kitao (N)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Hiroshi Nomoto (H)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Hiraku Kameda (H)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Kyu Yong Cho (KY)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Clinical Research and Medical Innovation Center, Hokkaido University Hospital, Sapporo, Japan.

Yasuo Terauchi (Y)

Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

Tatsuya Atsumi (T)

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bactéries à Gram positif formant des endospores › Clostridium › Clostridium histolyticum › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Glucokinase › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests de chimie clinique › Analyse chimique du sang › Hyperglycémie provoquée › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Métabolisme › Métabolome › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glucokinase Inactivation Paradoxically...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques d'amplification d'acides nucléiques › Réaction de polymérisation en chaîne › Réaction de polymérisation en chaine en temps réel › Glucokinase Inactivation Paradoxically...