Imaging atelectrauma in Ventilator-Induced Lung Injury using 4D X-ray microscopy.
Animals
Biomarkers
Data Analysis
Disease Models, Animal
Disease Progression
Microscopy
/ methods
Positive-Pressure Respiration
Rabbits
Respiration, Artificial
/ adverse effects
Respiratory Distress Syndrome
/ etiology
Tomography, X-Ray Computed
Ventilator-Induced Lung Injury
/ diagnostic imaging
X-Rays
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 02 2021
19 02 2021
Historique:
received:
23
06
2020
accepted:
04
11
2020
entrez:
20
2
2021
pubmed:
21
2
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain poorly understood. Here we investigated the within-tidal dynamics of cyclic recruitment/derecruitment (R/D) using synchrotron radiation phase-contrast imaging (PCI), and the relation between R/D and cell infiltration, in a model of Acute Respiratory Distress Syndrome in 6 anaesthetized and mechanically ventilated New-Zealand White rabbits. Dynamic PCI was performed at 22.6 µm voxel size, under protective mechanical ventilation [tidal volume: 6 ml/kg; positive end-expiratory pressure (PEEP): 5 cmH
Identifiants
pubmed: 33608569
doi: 10.1038/s41598-020-77300-x
pii: 10.1038/s41598-020-77300-x
pmc: PMC7895928
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4236Références
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