Changes in fatigue, barriers, and predictors towards physical activity in advanced cancer patients over a period of 12 months-a comparative study.
Advanced cancer patients
Barriers
Depression
Fatigue
Motivation
Physical activity
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
18
09
2020
accepted:
21
01
2021
pubmed:
21
2
2021
medline:
9
10
2021
entrez:
20
2
2021
Statut:
ppublish
Résumé
Physical activity (PA) is recommended to improve advanced cancer patients' (ACP) physical functioning, fatigue, and quality of life. Yet, little is known about ACPs' attitude towards PA and its influence on fatigue and depressiveness over a longer period. This prospective, non-interventional cohort study examined ACPs' fatigue, depression, motivation, and barriers towards PA before and after 12 months of treatment among ACP METHODS: Outpatients with incurable cancer receiving treatment at a German Comprehensive Cancer Center reporting moderate/severe weakness/tiredness during self-assessment via MIDOS II were enrolled. Fatigue (FACT-F), depression (PHQ-8), cancer-related parameters, self-assessed PA behavior, motivation for and barriers against PA were evaluated (T0). Follow-up data was acquired after 12 months (T1) using the same questionnaire. At follow-up, fatigue (p=0.017) and depressiveness (p=0.015) had increased in clinical relevant extent. Physically active ACP did not show significant progress of FACT-F (p=0.836) or PHQ-8 (p=0.799). Patient-reported barriers towards PA remained stable. Logistic regression analyses identified motivation as a positive predictor for PA at both time points (T0, β=2.152, p=0.017; T1, β =2.264, p=0.009). Clinically relevant depression was a negative predictor for PA at T0 and T1 (T0, β=-3.187, p=0.044; T1, β=-3.521, p=0.041). Our findings emphasize the importance of psychological conditions in physical activity behavior of ACP. Since psychological conditions seem to worsen over time, early integration of treatment is necessary. By combining therapy approaches of cognitive behavioral therapy and exercise in interdisciplinary care programs, the two treatment options might reinforce each other and sustainably improve ACPs' fatigue, physical functioning, and QoL. German Register of Clinical Trials, DRKS00012514, registration date: 30.05.2017.
Identifiants
pubmed: 33608761
doi: 10.1007/s00520-021-06020-3
pii: 10.1007/s00520-021-06020-3
pmc: PMC8295138
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5127-5137Informations de copyright
© 2021. The Author(s).
Références
Pinto BM, Trunzo JJ (2005) Health behaviors during and after a cancer diagnosis. Cancer 104:2614–2623
Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742
Curt GA, Breitbart W, Cella D, Groopman JE, Horning SJ, Itri LM, Johnson DH, Miaskowski C, Scherr SL, Portenoy RK, Vogelzang NJ (2000) Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition. Oncologist 5:353–360
Bayly JL, Lloyd-Williams M (2016) Identifying functional impairment and rehabilitation needs in patients newly diagnosed with inoperable lung cancer: a structured literature review. Support Care Cancer 24:2359–2379
Berger AM, Mooney K, Alvarez-Perez A, Breitbart WS, Carpenter KM, Cella D, Cleeland C, Dotan E, Eisenberger MA, Escalante CP, Jacobsen PB, Jankowski C, LeBlanc T, Ligibel JA, Loggers ET, Mandrell B, Murphy BA, Palesh O, Pirl WF, Plaxe SC, Riba MB, Rugo HS, Salvador C, Wagner LI, Wagner-Johnston ND, Zachariah FJ, Bergman MA, Smith C (2015) Cancer-related fatigue, version 2. 2015. J Nat Comprehens Cancer Network : JNCCN 13:1012–1039
Lawrence DP, Kupelnick B, Miller K, Devine D, Lau J (2004) Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients. J Natl Cancer Inst Monogr:40–50
Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR (2007) Cancer-related fatigue: the scale of the problem. Oncologist 12(Suppl 1):4–10
Eyigor S, Akdeniz S (2014) Is exercise ignored in palliative cancer patients? World J Clin Oncol 5:554–559
pubmed: 4127625
pmcid: 4127625
Jensen W, Baumann FT, Stein A, Bloch W, Bokemeyer C, de Wit M, Oechsle K (2014) Exercise training in patients with advanced gastrointestinal cancer undergoing palliative chemotherapy: a pilot study. Support Care Cancer 22:1797–1806
Oldervoll LM, Loge JH, Paltiel H, Asp MB, Vidvei U, Wiken AN, Hjermstad MJ, Kaasa S (2006) The effect of a physical exercise program in palliative care: a phase II study. J Pain Symptom Manag 31:421–430
Pyszora A, Budzyński J, Wójcik A, Prokop A, Krajnik M (2017) Physiotherapy programme reduces fatigue in patients with advanced cancer receiving palliative care: randomized controlled trial. Support Care Cancer 25:2899–2908
pubmed: 5527074
pmcid: 5527074
Poort H, Peters M, van der Graaf WTA, Nieuwkerk PT, van de Wouw AJ, Nijhuis-van der Sanden MWG, Bleijenberg G, Verhagen C, Knoop H (2020) Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial. Ann Oncol 31:115–122
Rock CL, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya KS, Schwartz AL, Bandera EV, Hamilton KK, Grant B, McCullough M, Byers T, Gansler T (2012) Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin 62:243–274
Frikkel J, Götte M, Beckmann M, Kasper S, Hense J, Teufel M, Schuler M, Tewes M (2020) Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced cancer patients. BMC Palliat Care 19:43
pubmed: 7110817
pmcid: 7110817
Granger CL, Connolly B, Denehy L, Hart N, Antippa P, Lin KY, Parry SM (2017) Understanding factors influencing physical activity and exercise in lung cancer: a systematic review. Support Care Cancer 25:983–999
Zopf EM, Newton RU, Taaffe DR, Spry N, Cormie P, Joseph D, Chambers SK, Baumann FT, Bloch W, Galvao DA (2017) Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: a cross-sectional investigation. Eur J Cancer Care 26
Blaney JM, Lowe-Strong A, Rankin-Watt J, Campbell A, Gracey JH (2013) Cancer survivors’ exercise barriers, facilitators and preferences in the context of fatigue, quality of life and physical activity participation: a questionnaire-survey. Psycho-oncology 22:186–194
Fernandez S, Franklin J, Amlani N, DeMilleVille C, Lawson D, Smith J (2015) Physical activity and cancer: a cross-sectional study on the barriers and facilitators to exercise during cancer treatment. Canadian Oncol Nurs J = Revue canadienne de nursing oncologique 25:37–48
Courneya KS, Friedenreich CM, Quinney HA, Fields AL, Jones LW, Vallance JK, Fairey AS (2005) A longitudinal study of exercise barriers in colorectal cancer survivors participating in a randomized controlled trial. Ann Behav Med 29:147–153
Bohn SH, Fossa SD, Wisloff T, Thorsen L (2019) Physical activity and associations with treatment-induced adverse effects among prostate cancer patients. Support Care Cancer 27:1001–1011
Eng L, Pringle D, Su J, Shen X, Mahler M, Niu C, Charow R, Tiessen K, Lam C, Halytskyy O, Naik H, Hon H, Irwin M, Pat V, Gonos C, Chan C, Villeneuve J, Harland L, Shani RM, Brown MC, Selby P, Howell D, Xu W, Liu G, Alibhai SMH, Jones JM (2018) Patterns, perceptions, and perceived barriers to physical activity in adult cancer survivors. Support Care Cancer 26:3755–3763
Mikkelsen MK, Nielsen DL, Vinther A, Lund CM, Jarden M (2019) Attitudes towards physical activity and exercise in older patients with advanced cancer during oncological treatment - a qualitative interview study. Eur J Oncol Nurs 41:16–23
Blaney J, Lowe-Strong A, Rankin J, Campbell A, Allen J, Gracey J (2010) The cancer rehabilitation journey: barriers to and facilitators of exercise among patients with cancer-related fatigue. Phys Ther 90:1135–1147
Sheill G, Guinan E, Neill LO, Hevey D, Hussey J (2018) The views of patients with metastatic prostate cancer towards physical activity: a qualitative exploration. Support Care Cancer 26:1747–1754
Peters ME, Goedendorp MM, Verhagen CA, Bleijenberg G, van der Graaf WT (2016) Fatigue and its associated psychosocial factors in cancer patients on active palliative treatment measured over time. Support Care Cancer 24:1349–1355
Susanne K, Michael F, Thomas S, Peter E, Andreas H (2019) Predictors of fatigue in cancer patients: a longitudinal study. Support Care Cancer 27:3463–3471
Poort H, de Rooij BH, Uno H, Weng S, Ezendam NPM, van de Poll-Franse L, Wright AA (2020) Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study. Cancer 126:3526–3533
pubmed: 32436610
pmcid: 32436610
Van Dijk-Lokkart EM, Steur LMH, Braam KI, Veening MA, Huisman J, Takken T, Bierings M, Merks JH, Van den Heuvel-Eibrink MM, Kaspers GJL, Van Dulmen-den Broeder E, Van Litsenburg RRL (2019) Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients. Pediatric Blood & Cancer 66:e27949
Verkissen MN, Hjermstad MJ, Van Belle S, Kaasa S, Deliens L, Pardon K (2019) Quality of life and symptom intensity over time in people with cancer receiving palliative care: results from the international European Palliative Care Cancer Symptom study. PLoS One 14:e0222988
pubmed: 6784977
pmcid: 6784977
Stiel S, Matthes ME, Bertram L, Ostgathe C, Elsner F, Radbruch L (2010) Validation of the new version of the minimal documentation system (MIDOS) for patients in palliative care : the German version of the Edmonton symptom assessment scale (ESAS). Schmerz (Berlin, Germany) 24:596–604
Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE (2002) Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manag 24:547–561
Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E (1997) Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manag 13:63–74
Cella D (1997) The Functional Assessment of Cancer Therapy-Anemia (FACT-An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol 34:13–19
Van Belle S, Paridaens R, Evers G, Kerger J, Bron D, Foubert J, Ponnet G, Vander Steichel D, Heremans C, Rosillon D (2005) Comparison of proposed diagnostic criteria with FACT-F and VAS for cancer-related fatigue: proposal for use as a screening tool. Support Care Cancer 13:246–254
Kroenke K, Spitzer RL (2002) The PHQ-9: a new depression and diagnostic severity measure. Psychiatr Ann 32:509–521
Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613
pubmed: 11556941
pmcid: 11556941
Kroenke K, Strine TW, Spitzer RL, Williams JB, Berry JT, Mokdad AH (2009) The PHQ-8 as a measure of current depression in the general population. J Affect Disord 114:163–173
Granger CL, Denehy L, Remedios L, Retica S, Phongpagdi P, Hart N, Parry SM (2016) Barriers to translation of physical activity into the lung cancer model of care. A qualitative study of clinicians’ perspectives. Ann Am Thorac Soc 13:2215–2222
Hefferon K, Murphy H, McLeod J, Mutrie N, Campbell A (2013) Understanding barriers to exercise implementation 5-year post-breast cancer diagnosis: a large-scale qualitative study. Health Educ Res 28:843–856
Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175–191
Cohen J (1988) Statistical power analysis for the behavioral sciences. L. Erlbaum Associates, Hillsdale, N.J.
Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH (2018) Cancer-associated cachexia. Nat Rev Dis Primers 4:17105
Solheim TS, Laird BJA, Balstad TR, Stene GB, Bye A, Johns N, Pettersen CH, Fallon M, Fayers P, Fearon K, Kaasa S (2017) A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer. J Cachexia Sarcopenia Muscle 8:778–788
pubmed: 5659068
pmcid: 5659068
Cormie P, Newton RU, Spry N, Joseph D, Taaffe DR, Galvão DA (2013) Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases. Prostate Cancer Prostatic Dis 16:328–335
Tsianakas V, Harris J, Ream E, Van Hemelrijck M, Purushotham A, Mucci L, Green JS, Fewster J, Armes J (2017) CanWalk: a feasibility study with embedded randomised controlled trial pilot of a walking intervention for people with recurrent or metastatic cancer. BMJ Open 7:e013719
pubmed: 5318561
pmcid: 5318561
Nipp RD, Fuchs G, El-Jawahri A, Mario J, Troschel FM, Greer JA, Gallagher ER, Jackson VA, Kambadakone A, Hong TS, Temel JS, Fintelmann FJ (2018) Sarcopenia Is associated with quality of life and depression in patients with advanced cancer. Oncologist 23:97–104
Beernaert K, Pardon K, Van den Block L, Devroey D, De Laat M, Geboes K, Surmont V, Deliens L, Cohen J (2016) Palliative care needs at different phases in the illness trajectory: a survey study in patients with cancer. Eur J Cancer Care 25:534–543
Dittus KL, Gramling RE, Ades PA (2017) Exercise interventions for individuals with advanced cancer: a systematic review. Prev Med 104:124–132
Ungar N, Wiskemann J, Sieverding M (2016) Physical activity enjoyment and self-efficacy as predictors of cancer patients' physical activity level. Front Psychol 7:898
pubmed: 4914598
pmcid: 4914598
Ormel HL, van der Schoot GGF, Sluiter WJ, Jalving M, Gietema JA, Walenkamp AME (2018) Predictors of adherence to exercise interventions during and after cancer treatment: a systematic review. Psycho-oncology 27:713–724
pubmed: 5887924
pmcid: 5887924