In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis.
COVID-19
In-hospital
Mortality
Pre-admission
SARS-CoV-2
Statins
Journal
Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
28
12
2020
accepted:
08
02
2021
revised:
27
01
2021
pubmed:
21
2
2021
medline:
22
6
2021
entrez:
20
2
2021
Statut:
ppublish
Résumé
The idea of treating COVID-19 with statins is biologically plausible, although it is still controversial. The systematic review and meta-analysis aimed to address the association between the use of statins and risk of mortality in patients with COVID-19. Several electronic databases, including PubMed, SCOPUS, EuropePMC, and the Cochrane Central Register of Controlled Trials, with relevant keywords up to 11 November 2020, were used to perform a systematic literature search. This study included research papers containing samples of adult COVID-19 patients who had data on statin use and recorded mortality as their outcome of interest. Risk estimates of mortality in statin users versus non-statin users were pooled across studies using inverse-variance weighted DerSimonian-Laird random-effect models. Thirteen studies with a total of 52,122 patients were included in the final qualitative and quantitative analysis. Eight studies reported in-hospital use of statins; meanwhile, the remaining studies reported pre-admission use of statins. In-hospital use of statin was associated with a reduced risk of mortality (RR 0.54, 95% CI 0.50-0.58, p < 0.00001; I This meta-analysis showed that in-hospital use of statins was associated with a reduced risk of mortality in patients with COVID-19.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
The idea of treating COVID-19 with statins is biologically plausible, although it is still controversial. The systematic review and meta-analysis aimed to address the association between the use of statins and risk of mortality in patients with COVID-19.
METHODS
METHODS
Several electronic databases, including PubMed, SCOPUS, EuropePMC, and the Cochrane Central Register of Controlled Trials, with relevant keywords up to 11 November 2020, were used to perform a systematic literature search. This study included research papers containing samples of adult COVID-19 patients who had data on statin use and recorded mortality as their outcome of interest. Risk estimates of mortality in statin users versus non-statin users were pooled across studies using inverse-variance weighted DerSimonian-Laird random-effect models.
RESULTS
RESULTS
Thirteen studies with a total of 52,122 patients were included in the final qualitative and quantitative analysis. Eight studies reported in-hospital use of statins; meanwhile, the remaining studies reported pre-admission use of statins. In-hospital use of statin was associated with a reduced risk of mortality (RR 0.54, 95% CI 0.50-0.58, p < 0.00001; I
CONCLUSION
CONCLUSIONS
This meta-analysis showed that in-hospital use of statins was associated with a reduced risk of mortality in patients with COVID-19.
Identifiants
pubmed: 33608850
doi: 10.1007/s43440-021-00233-3
pii: 10.1007/s43440-021-00233-3
pmc: PMC7895740
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
769-780Références
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1241-1242
pubmed: 32683322
J Am Med Dir Assoc. 2020 Jul;21(7):909-914.e2
pubmed: 32674818
Ann Transl Med. 2016 Nov;4(21):421
pubmed: 27942512
J Am Heart Assoc. 2020 Dec 15;9(24):e018475
pubmed: 33092446
Lancet Respir Med. 2021 Mar;9(3):275-284
pubmed: 33422263
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
Can J Kidney Health Dis. 2020 Jul 7;7:2054358120938573
pubmed: 32685180
Diabetes Metab Syndr. 2020 Nov-Dec;14(6):1613-1615
pubmed: 32882643
Inflamm Regen. 2020 Oct 1;40:37
pubmed: 33014208
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620937175
pubmed: 32615866
Cell Metab. 2020 Aug 4;32(2):176-187.e4
pubmed: 32592657
J Am Coll Cardiol. 2020 Aug 4;76(5):533-546
pubmed: 32517963
Intern Emerg Med. 2020 Nov;15(8):1573-1576
pubmed: 33011928
Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):258-259
pubmed: 32347925
Am J Cardiol. 2020 Nov 1;134:153-155
pubmed: 32891399
J Health Econ Outcomes Res. 2020 Sep 29;7(2):165-174
pubmed: 33043063
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Eur Heart J Cardiovasc Pharmacother. 2022 Feb 16;8(2):157-164
pubmed: 33135047
J Am Coll Cardiol. 2020 Jul 7;76(1):122-124
pubmed: 32387623
Crit Care. 2020 Jul 14;24(1):429
pubmed: 32664990
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
J Infect Dis. 2012 Jan 1;205(1):13-9
pubmed: 22170954
Arch Med Sci. 2020 Apr 25;16(3):490-496
pubmed: 32399094
Clin Rev Allergy Immunol. 2021 Apr;60(2):175-199
pubmed: 32378144
Atherosclerosis. 2012 Dec;225(2):381-7
pubmed: 23062767
Clin Med (Lond). 2017 Oct;17(5):403-407
pubmed: 28974587
Antiviral Res. 2013 Sep;99(3):417-35
pubmed: 23831494
Open Forum Infect Dis. 2015 Mar 20;2(1):ofv028
pubmed: 26034777
Int J Infect Dis. 2020 Jul;96:615-617
pubmed: 32502659
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Atherosclerosis. 2015 Aug;241(2):433-42
pubmed: 26074317
Ther Apher Dial. 2021 Oct;25(5):706-709
pubmed: 33040468
mBio. 2020 Mar 20;11(2):
pubmed: 32198163
Expert Rev Respir Med. 2020 Nov;14(11):1149-1163
pubmed: 32734777
Pharmacol Res. 2020 Jun;156:104803
pubmed: 32289478
J Clin Med. 2020 Jun 18;9(6):
pubmed: 32570882
Diabetes Metab. 2021 Mar;47(2):101202
pubmed: 33091555
Thromb Haemost. 2016 Mar;115(3):520-32
pubmed: 26632869
Biochem Pharmacol. 2015 Feb 1;93(3):343-51
pubmed: 25482567
EClinicalMedicine. 2020 Dec;29:100639
pubmed: 33251499
J Clin Anesth. 2020 Dec;67:110005
pubmed: 32707517
Circulation. 2005 May 24;111(20):2605-10
pubmed: 15897343
Signal Transduct Target Ther. 2020 Dec 4;5(1):283
pubmed: 33277466
Clin Med Insights Circ Respir Pulm Med. 2020 Sep 17;14:1179548420959165
pubmed: 32994700
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Pathogens. 2020 Sep 17;9(9):
pubmed: 32957539
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620960797
pubmed: 33079569
Intensive Care Med. 2020 Aug;46(8):1603-1606
pubmed: 32415314
Thromb Res. 2020 Oct;194:101-115
pubmed: 32788101
Am J Cardiol. 2020 Dec 1;136:149-155
pubmed: 32946859
Pediatr Crit Care Med. 2013 Nov;14(9):e438-41
pubmed: 24226567
Am J Emerg Med. 2021 Aug;46:204-211
pubmed: 33071085