Astrocytes in stress accumulate lipid droplets.

Animals Astrocytes Drosophila Endoplasmic Reticulum / metabolism Lipid Droplets / metabolism Mitochondria Rats
adrenergic receptors astrocytes lipid droplets metabolic/hypoxic stress noradrenaline

Journal

Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785

Informations de publication

Date de publication:
06 2021
Historique:
revised: 14 01 2021
received: 11 07 2020
accepted: 01 02 2021
pubmed: 21 2 2021
medline: 10 2 2022
entrez: 20 2 2021
Statut: ppublish

Résumé

When the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and mechanisms leading to LD accumulation in astrocytes, glial cells with key homeostatic functions, are poorly understood. We imaged fluorescently labeled LDs by microscopy in isolated and brain tissue rat astrocytes and in glia-like cells in Drosophila brain to determine the (sub)cellular localization, mobility, and content of LDs under various stress conditions characteristic for brain pathologies. LDs exhibited confined mobility proximal to mitochondria and endoplasmic reticulum that was attenuated by metabolic stress and by increased intracellular Ca

Identifiants

DOI: 10.1002/glia.23978 PMID: 33609060 PMC: PMC8248329
pubmed: 33609060
doi: 10.1002/glia.23978
pmc: PMC8248329
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1540-1562

Informations de copyright

© 2021 The Authors. Glia published by Wiley Periodicals LLC.

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Auteurs

Tina Smolič (T)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.

Petra Tavčar (P)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.

Anemari Horvat (A)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Laboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia.

Urška Černe (U)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.

Ana Halužan Vasle (A)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.

Larisa Tratnjek (L)

Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia.

Mateja Erdani Kreft (ME)

Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia.

Nicole Scholz (N)

Division of General Biochemistry, Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, Leipzig University, Leipzig, Germany.

Maja Matis (M)

Medical Faculty, Institute of Cell Biology, University of Münster, Münster, Germany.
Cells in Motion Interfaculty Centre, University of Münster, Münster, Germany.

Toni Petan (T)

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia.

Robert Zorec (R)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Laboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia.
ORCID: 0000-0002-7478-3875

Nina Vardjan (N)

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Laboratory of Cell Engineering, Celica Biomedical, Ljubljana, Slovenia.
ORCID: 0000-0001-8174-1668

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Astrocytes in stress accumulate lipid droplets.
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Astrocytes in stress accumulate lipid droplets.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Astrocytes in stress accumulate lipid droplets.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Astrocytes in stress accumulate lipid droplets.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Gouttelettes lipidiques › Astrocytes in stress accumulate lipid droplets.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Astrocytes in stress accumulate lipid droplets.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Astrocytes in stress accumulate lipid droplets.