The future of continuous renal replacement therapy.

continuous renal replacement therapy hemodiafiltration hemodialysis hemofiltration information technology prescription

Journal

Seminars in dialysis
ISSN: 1525-139X
Titre abrégé: Semin Dial
Pays: United States
ID NLM: 8911629

Informations de publication

Date de publication:
11 2021
Historique:
revised: 07 01 2021
received: 19 11 2020
accepted: 23 01 2021
pubmed: 21 2 2021
medline: 15 3 2022
entrez: 20 2 2021
Statut: ppublish

Résumé

Over the last 40 years, acute renal replacement therapy (RRT) in the intensive care units (ICUs) of high-income countries has transitioned from the predominant use of intermittent hemodialysis (and the much less common use of peritoneal dialysis) to the almost exclusive use of continuous renal replacement therapy (CRRT). Accordingly, CRRT has become the most common form of vital organ support delivered to critically ill patients. A series of clinical and technical advances has enabled the transformation of basic CRRT machines into highly sophisticated and customized devices. Recent work has focused on using evidence from clinical trials to enhance the application of CRRT with regard to timing of initiation, choice of modality, dose, and anticoagulation. However, many questions remain unanswered. Uncertainty surrounding volume control and the utility of strategies to minimize circulatory stress are key areas for future development. Advances in membrane technology, combination with other extracorporeal therapies, and personalization of CRRT delivery may provide additional benefit to certain subgroups. Development of quality metrics and use of data analytics to audit and benchmark could provide important insight into practice, while biofeedback and automated CRRT prescription could increase safety. In this review, we summarize the evolution of CRRT and highlight several future areas for development.

Identifiants

pubmed: 33609407
doi: 10.1111/sdi.12961
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

576-585

Informations de copyright

© 2021 Wiley Periodicals LLC.

Références

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Auteurs

Emily See (E)

Department of Intensive Care, Austin Hospital, Heidelberg, Vic., Australia.
Department of Nephrology, The Royal Melbourne Hospital, Parkville, Vic., Australia.
Centre for Integrated Critical Care, School of Medicine, University of Melbourne, Parkville, Vic., Australia.

Claudio Ronco (C)

Chair of Nephrology, Department of Medicine, University of Padova, Padova, Italy.
International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy.
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

Rinaldo Bellomo (R)

Department of Intensive Care, Austin Hospital, Heidelberg, Vic., Australia.
Centre for Integrated Critical Care, School of Medicine, University of Melbourne, Parkville, Vic., Australia.
Department of Intensive Care, The Royal Melbourne Hospital, Parkville, Vic., Australia.

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