Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients.


Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
May 2021
Historique:
received: 30 10 2020
revised: 05 02 2021
accepted: 07 02 2021
pubmed: 21 2 2021
medline: 15 5 2021
entrez: 20 2 2021
Statut: ppublish

Résumé

There is not much awareness of varicella zoster virus (VZV) associated central nervous system (CNS) infections under treatment with natalizumab. Here we describe two natalizumab treated MS patients who developed acute retinal necrosis combined with CNS vasculitis caused by VZV. In natalizumab treated patients, visual symptoms atypical of optic neuritis should be promptly evaluated by an ophthalmologist. Currently, a total of 12 cases of natalizumab-associated VZV CNS or retinal infections are reported in literature. Our two cases and overview of currently available data provide information on prognosis and treatment decisions of this rare but devastating complication.

Identifiants

pubmed: 33609925
pii: S2211-0348(21)00104-8
doi: 10.1016/j.msard.2021.102838
pii:
doi:

Substances chimiques

Natalizumab 0

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

102838

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Zoé L E van Kempen (ZLE)

Department of Neurology, MS Center Amsterdam, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands. Electronic address: z.vankempen@amsterdamumc.nl.

Johannis A van Rossum (JA)

Department of Neurology, MS Center Amsterdam, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands.

Erwin Hoogervorst (E)

Department of Neurology, St. Antonius Hospital, Utrecht, the Netherlands.

Eva Strijbis (E)

Department of Neurology, MS Center Amsterdam, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands.

Alyssa Toorop (A)

Department of Neurology, MS Center Amsterdam, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands.

Machteld I Bosscha (MI)

Department of Ophthalmology, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands.

Stephan Frequin (S)

Department of Neurology, St. Antonius Hospital, Utrecht, the Netherlands.

Ninette Ten Dam-van Loon (NT)

Department of Ophthalmology, UMC Utrecht, Utrecht, the Netherlands.

Mike P Wattjes (MP)

Department of Radiology, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands; Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.

Jean-Luc Murk (JL)

Microvida, St. Elisabeth Tweesteden Hospital Tilburg, Tilburg, the Netherlands.

Joep Killestein (J)

Department of Neurology, MS Center Amsterdam, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands.

Bernard M J Uitdehaag (BMJ)

Department of Neurology, MS Center Amsterdam, Amsterdam UMC - location VUmc, Amsterdam, the Netherlands.

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Classifications MeSH