Late-onset hypogonadism: Clinical evidence, biological aspects and evolutionary considerations.
Endocrinology
Evolution
Hormones
Late-onset hypogonadism
TRT
Testosterone
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
09
10
2020
revised:
23
11
2020
accepted:
15
02
2021
pubmed:
22
2
2021
medline:
20
4
2021
entrez:
21
2
2021
Statut:
ppublish
Résumé
The growing life expectancy in modern societies has raised scientific interest in identifying medical interventions to alleviate age-associated pathologies such as vascular calcification, cognitive decline, sarcopenia, osteoporosis and sexual dysfunction. Although no such single treatment has thus far been established in humans, some clinicians and patients have set their hopes on testosterone replacement therapy (TRT) as a potential "fountain of youth" for aging men. While TRT has proven effective in ameliorating distinct symptoms of late-onset hypogonadism (LOH), its safety remains to be demonstrated. Besides humans, multiple other species exhibit age-related reductions in circulating testosterone levels, raising the question whether such changes are an inherent, pathological feature of growing organismal age or rather reflect an adaptive response. In this manuscript, we apply key principles of evolutionary medicine to testosterone biology and LOH to provide a novel perspective on these two fields. Additionally, we discuss insightful data derived from the animal kingdom to illustrate the plasticity of individual testosterone trajectories across the lifespan, outline cost-benefit-considerations of TRT in LOH and highlight potential caveats of such therapies.
Identifiants
pubmed: 33610812
pii: S1568-1637(21)00048-9
doi: 10.1016/j.arr.2021.101301
pmc: PMC8043243
mid: NIHMS1675924
pii:
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101301Subventions
Organisme : NIAID NIH HHS
ID : K08 AI128745
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
Aging Cell. 2009 Jun;8(3):277-87
pubmed: 19627267
J Endocrinol Invest. 2007 Jun;30(6):451-8
pubmed: 17646718
Andrology. 2013 Jan;1(1):17-23
pubmed: 23258625
Am J Hum Biol. 2005 Sep-Oct;17(5):527-58
pubmed: 16136532
Eur Urol. 2018 Nov;74(5):585-594
pubmed: 30077399
FEBS J. 2019 Jan;286(2):241-278
pubmed: 30027602
Arch Neurol. 2006 May;63(5):729-35
pubmed: 16682542
J Neurol Sci. 2010 Nov 15;298(1-2):1-10
pubmed: 20846673
Gen Comp Endocrinol. 2019 Aug 1;279:164-173
pubmed: 30904390
Steroids. 1988 Oct;52(4):339-40
pubmed: 3074526
Cell Metab. 2016 Jun 14;23(6):1022-1033
pubmed: 27304504
Mol Cell Endocrinol. 2014 Jan 25;382(1):107-119
pubmed: 24064031
Hum Reprod Update. 2004 Sep-Oct;10(5):409-19
pubmed: 15297434
Science. 2019 Jan 11;363(6423):
pubmed: 30630899
Ann Neurol. 2009 Feb;65(2):140-50
pubmed: 19259967
Exp Gerontol. 1976;11(1-2):25-32
pubmed: 1278267
J Appl Physiol (1985). 1989 Jan;66(1):498-503
pubmed: 2917954
Andrologia. 1998 Mar-Apr;30(2):105-8
pubmed: 9629432
Lancet. 2020 Mar 7;395(10226):795-808
pubmed: 31492503
J Endocrinol. 2013 Apr 29;217(3):R25-45
pubmed: 23378050
N Engl J Med. 2010 Jul 8;363(2):123-35
pubmed: 20554979
Front Neuroendocrinol. 2014 Aug;35(3):370-84
pubmed: 24607323
Neurotherapeutics. 2019 Oct;16(4):928-947
pubmed: 31686397
Ageing Res Rev. 2015 Jan;19:22-33
pubmed: 25462195
Nature. 2009 Jul 16;460(7253):392-5
pubmed: 19587680
Horm Metab Res. 1981 Jun;13(6):356-8
pubmed: 6943120
Ann N Y Acad Sci. 2017 Feb;1389(1):92-107
pubmed: 28009055
Steroids. 2014 Aug;86:5-9
pubmed: 24793565
J Clin Endocrinol Metab. 2017 Feb 1;102(2):583-593
pubmed: 27754805
J Reprod Fertil. 1976 Nov;48(2):291-300
pubmed: 994101
J Clin Endocrinol Metab. 2000 Apr;85(4):1461-6
pubmed: 10770182
Trends Endocrinol Metab. 2019 Mar;30(3):163-176
pubmed: 30691778
J Urol. 2019 Mar;201(3):587-594
pubmed: 30296416
Neuron. 2010 Sep 23;67(6):936-52
pubmed: 20869592
Lancet Neurol. 2010 Sep;9(9):875-84
pubmed: 20691641
J Crohns Colitis. 2019 Apr 26;13(5):564-571
pubmed: 30500868
Andrology. 2013 Mar;1(2):229-39
pubmed: 23315971
Endocr Rev. 2018 Jun 1;39(3):369-386
pubmed: 29522088
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5664-9
pubmed: 27143723
Trends Cardiovasc Med. 2020 Oct;30(7):399-404
pubmed: 31519403
Hum Biol. 1996 Dec;68(6):955-65
pubmed: 8979466
Cochrane Database Syst Rev. 2017 Jan 17;1:CD004143
pubmed: 28093732
Neuron. 2002 Aug 29;35(5):843-54
pubmed: 12372280
J Clin Endocrinol Metab. 2006 Nov;91(11):4335-43
pubmed: 16926258
Arch Intern Med. 2007 Jun 25;167(12):1252-60
pubmed: 17592098
Best Pract Res Clin Endocrinol Metab. 2015 Jan;29(1):77-90
pubmed: 25617174
Nat Clin Pract Urol. 2006 Dec;3(12):653-65
pubmed: 17149382
Eur J Endocrinol. 2019 Jun 1;180(6):R201-R212
pubmed: 30959485
Conserv Physiol. 2018 Sep 21;6(1):coy049
pubmed: 30254748
Clin Cardiol. 2018 Feb;41(2):247-252
pubmed: 29493798
Horm Behav. 2009 Oct;56(4):472-80
pubmed: 19712676
Front Neurol. 2013 May 15;4:53
pubmed: 23720649
Hum Genet. 1982;60(2):101-21
pubmed: 7042533
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):869-74
pubmed: 24367114
J Neurol. 2018 May;265(5):1026-1036
pubmed: 29464380
Eur J Endocrinol. 2011 Nov;165(5):687-701
pubmed: 21852391
Nat Med. 2018 May;24(4):427-437
pubmed: 29505030
Med Sci Sports Exerc. 2013 Sep;45(9):1712-20
pubmed: 23470307
J Biochem Physiol. 2018;1(1):
pubmed: 29882545
Andrology. 2018 Nov;6(6):846-853
pubmed: 30006962
Int J Cardiol. 2013 Sep 30;168(2):934-45
pubmed: 23218570
Eur Heart J. 2015 Oct 21;36(40):2706-15
pubmed: 26248567
Horm Behav. 1981 Sep;15(3):238-45
pubmed: 7298026
Eur Urol. 2009 Feb;55(2):310-20
pubmed: 18838208
Int J Biochem Cell Biol. 2019 Jun;111:1-10
pubmed: 30940605
BMJ. 2019 Mar 6;364:l476
pubmed: 30842065
Clin Endocrinol (Oxf). 2013 Apr;78(4):629-34
pubmed: 22901104
J Clin Invest. 2019 May 1;129(5):1818-1826
pubmed: 31042159
Nat Rev Mol Cell Biol. 2019 Jul;20(7):421-435
pubmed: 30733602
Hum Reprod Update. 2011 Jul-Aug;17(4):495-500
pubmed: 21335359
Endocr Rev. 2019 Apr 1;40(2):575-601
pubmed: 30576428
Proc Biol Sci. 2012 Nov 7;279(1746):4305-21
pubmed: 22933370
Clin Endocrinol (Oxf). 2013 Mar;78(3):321-9
pubmed: 23121642
Science. 2016 Jul 1;353(6294):aac4354
pubmed: 27365453
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1451-7
pubmed: 16339333
J Neurochem. 1994 Jan;62(1):94-101
pubmed: 8263548
J Clin Endocrinol Metab. 2002 Feb;87(2):589-98
pubmed: 11836290
Cell Metab. 2017 Dec 5;26(6):884-896.e5
pubmed: 29107506
J Clin Endocrinol Metab. 2014 Apr;99(4):1357-66
pubmed: 24423283
Am J Cardiol. 2019 Jun 1;123(11):1757-1764
pubmed: 30928032
Aging Cell. 2010 Apr;9(2):236-42
pubmed: 20096034
Rev Endocr Metab Disord. 2015 Sep;16(3):199-211
pubmed: 26373946
J Clin Endocrinol Metab. 2018 May 1;103(5):1715-1744
pubmed: 29562364
Chest. 2016 Sep;150(3):563-71
pubmed: 27179907
Cell Metab. 2019 Sep 3;30(3):573-593.e8
pubmed: 31353263
Cardiovasc Res. 2005 Jan 1;65(1):148-57
pubmed: 15621042
Curr Biol. 2012 Sep 25;22(18):R792-3
pubmed: 23017989
Brain. 2006 Jun;129(Pt 6):1446-55
pubmed: 16621916
J Clin Endocrinol Metab. 2018 Sep 1;103(9):3466-3476
pubmed: 29939279
J Clin Endocrinol Metab. 2009 Jul;94(7):2353-9
pubmed: 19351733
N Engl J Med. 2013 Dec 19;369(25):2457
pubmed: 24350954
Mayo Clin Proc. 2007 Jan;82(1):29-39
pubmed: 17285783
Andrology. 2020 Nov;8(6):1506-1511
pubmed: 31639279
J Clin Endocrinol Metab. 2014 Jun;99(6):2061-8
pubmed: 24628549
JAMA. 2013 Nov 6;310(17):1829-36
pubmed: 24193080
Mayo Clin Proc. 2016 Jul;91(7):908-26
pubmed: 27343020
Science. 2011 Jul 15;333(6040):357-60
pubmed: 21764751
Hum Mol Genet. 2010 Feb 1;19(3):535-44
pubmed: 19933169
Osteoporos Int. 2009 Jul;20(7):1175-82
pubmed: 19020920
Br Med Bull. 2009;92:7-32
pubmed: 19776034
N Engl J Med. 2003 Jul 17;349(3):215-24
pubmed: 12824459
J Neural Transm Park Dis Dement Sect. 1994;8(3):215-21
pubmed: 7538305
J Steroid Biochem. 1988 Apr;29(4):435-40
pubmed: 3374133
N Engl J Med. 2016 Feb 18;374(7):611-24
pubmed: 26886521
Science. 2002 Aug 23;297(5585):1339-43
pubmed: 12193785
Asian J Androl. 2014 Mar-Apr;16(2):295-304
pubmed: 24435050
Hum Reprod. 2002 Dec;17(12):3251-3
pubmed: 12456632
J Neurol Neurosurg Psychiatry. 2017 Dec;88(12):1026-1032
pubmed: 28780536
BMC Med. 2013 Apr 18;11:108
pubmed: 23597181
J Exp Biol. 2018 Aug 23;221(Pt 16):
pubmed: 29941613
Curr Biol. 2012 Sep 11;22(17):R733-40
pubmed: 22975004
Sex Med. 2015 Sep 17;3(4):269-79
pubmed: 26797061
J Clin Endocrinol Metab. 1988 Sep;67(3):460-4
pubmed: 2842359
Scand J Clin Lab Invest. 2017 Dec;77(8):582-586
pubmed: 28644096
Nat Rev Cardiol. 2019 Sep;16(9):555-574
pubmed: 31123340
Aging Male. 2020 Mar;23(1):81-92
pubmed: 30782054
Nat Rev Endocrinol. 2009 Dec;5(12):673-81
pubmed: 19859074
PLoS One. 2015 Mar 26;10(3):e0122279
pubmed: 25811990