New drug approvals for 2020: Synthesis and clinical applications.
Chemical synthesis
Clinical applications
New drugs
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Apr 2021
05 Apr 2021
Historique:
received:
24
01
2021
revised:
03
02
2021
accepted:
03
02
2021
pubmed:
22
2
2021
medline:
27
5
2021
entrez:
21
2
2021
Statut:
ppublish
Résumé
53 New drugs including 38 chemical entities and 15 biologics were approved by the U.S. Food and Drug Administration during 2020. Among the marketed drugs, 34 new small molecule drugs and 4 new diagnostic agents with privileged structures and novel clinical applications represent as promising leads for the development of new drugs with the similar indications and improved therapeutic efficacy. This review is mainly focused on the clinical applications and synthetic methods of 34 small-molecule drugs newly approved by the FDA in 2020.
Identifiants
pubmed: 33611190
pii: S0223-5234(21)00133-1
doi: 10.1016/j.ejmech.2021.113284
pii:
doi:
Substances chimiques
Organic Chemicals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113284Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.