Baseline Urinary Angiotensinogen Excretion Predicts Deterioration of the Kidney Function in Patients with Chronic Kidney Disease.
chronic kidney disease
intrarenal renin-angiotensin system
renal prognosis
urinary angiotensinogen
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
pubmed:
23
2
2021
medline:
17
7
2021
entrez:
22
2
2021
Statut:
ppublish
Résumé
Objective The intrarenal renin-angiotensin system (RAS) is activated in patients with chronic kidney disease (CKD), and urinary angiotensinogen (AGT) levels, a surrogate marker of the intrarenal RAS activation, are associated with blood pressure (BP) and urinary albumin excretion. In addition, it has been shown that changes in urinary AGT levels correlate with annual changes in the estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes and that elevated levels of urinary AGT in type 2 diabetic patients with albuminuria are a high-risk factor for worsening renal and cardiovascular complications. However, whether or not baseline urinary AGT levels predict deterioration of the kidney function in all patients with CKD is unclear. Methods We recruited 62 patients with CKD whose eGFR was >15 mL/min/1.73 m
Identifiants
pubmed: 33612680
doi: 10.2169/internalmedicine.6599-20
pmc: PMC8355400
doi:
Substances chimiques
Angiotensinogen
11002-13-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2201-2206Références
J Korean Med Sci. 2017 May;32(5):782-788
pubmed: 28378551
Am J Physiol Renal Physiol. 2004 Jun;286(6):F1039-45
pubmed: 14722017
Pharmacol Rev. 2007 Sep;59(3):251-87
pubmed: 17878513
J Am Soc Nephrol. 2003 Apr;14(4):873-80
pubmed: 12660321
Clin Exp Pharmacol Physiol. 2009 May;36(5-6):509-15
pubmed: 19673933
J Am Soc Hypertens. 2008 Sep-Oct;2(5):349-54
pubmed: 18958182
Am J Physiol Renal Physiol. 2007 Sep;293(3):F956-60
pubmed: 17553939
Hypertension. 2008 Dec;52(6):1155-60
pubmed: 18936344
Clin Exp Nephrol. 2016 Dec;20(6):878-884
pubmed: 26743744
J Am Soc Nephrol. 2007 May;18(5):1558-65
pubmed: 17409316
Am J Kidney Dis. 2009 Jun;53(6):982-92
pubmed: 19339088
PLoS One. 2016 Nov 1;11(11):e0165703
pubmed: 27802313
Nephrol Dial Transplant. 2012 Aug;27(8):3218-23
pubmed: 22510379
Clin Exp Nephrol. 2015 Apr;19(2):231-9
pubmed: 24728489
J Diabetes Investig. 2012 Jun;3(3):318-324
pubmed: 22822420
Intern Med. 2019 Mar 1;58(5):643-648
pubmed: 30333423
Intern Med. 2016;55(23):3427-3433
pubmed: 27904104
Am J Med Sci. 2009 Dec;338(6):478-80
pubmed: 19884815
Am J Physiol Renal Physiol. 2007 Sep;293(3):F938-45
pubmed: 17634399
Hypertension. 1996 Mar;27(3 Pt 2):465-75
pubmed: 8613188
Hypertens Res. 2016 May;39(5):312-20
pubmed: 26739872
J Nephrol. 2019 Oct;32(5):775-781
pubmed: 30955155
Kidney Int. 2002 Feb;61(2):579-85
pubmed: 11849399
Int Rev Thromb. 2011;6(2):108-116
pubmed: 22022346
Cardiovasc Res. 1971 Jan;5(1):86-9
pubmed: 4322712
Hypertension. 2009 Feb;53(2):344-50
pubmed: 19075095
Nephrol Dial Transplant. 2011 Jan;26(1):170-7
pubmed: 20615910