Mathematical modeling and experimental analysis of the efficacy of photodynamic therapy in conjunction with photo thermal therapy and PEG-coated Au-doped TiO
MCF-7 cancerous cells
NRA, Neutral red assay
PEG, Polyethylene glycol
PEG-coated Au-doped Titanium oxide (TiO2) nanostructures
Photodynamic therapy (PDT)
Photothermal therapy/(HET)
RMSE, Root mean square error
SPR, Surface plasmon resonance
TEM, Transmission electron microscope
Journal
Saudi journal of biological sciences
ISSN: 1319-562X
Titre abrégé: Saudi J Biol Sci
Pays: Saudi Arabia
ID NLM: 101543796
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
10
11
2020
revised:
25
11
2020
accepted:
30
11
2020
entrez:
22
2
2021
pubmed:
23
2
2021
medline:
23
2
2021
Statut:
ppublish
Résumé
Some nanoscale morphologies of titanium oxide nanostructures blend with gold nanoparticles and act as satellites and targeted weapon methodologies in biomedical applications. Simultaneously, titanium oxide can play an important role when combined with gold after blending with polyethylene glycol (PEG). Our experimental approach is novel with respect to the plasmonic role of metal nanoparticles as an efficient PDT drug. The current experimental strategy floats the comprehensive and facile way of experimental strategy on the critical influence that titanium with gold nanoparticles used as novel photosensitizing agents after significant biodistribution of proposed nanostructures toward targeted site. In addition, different morphologies of PEG-coated Au-doped titanium nanostructures were shown to provide various therapeutic effects due to a wide range of electromagnetic field development. This confirms a significantly amplified population of hot electron generation adjacent to the interface between Au and TiO
Identifiants
pubmed: 33613051
doi: 10.1016/j.sjbs.2020.11.086
pii: S1319-562X(20)30650-1
pmc: PMC7878829
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1226-1232Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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