BK Virus-Associated Urothelial Carcinoma in a Patient with Peripheral Blood Stem Cell Transplantation for Acute Lymphoblastic Leukemia: A Case Report.
BK virus
Bladder
Hemorrhagic cystitis
Peripheral blood stem cell transplantation
Urothelial carcinoma
Journal
Case reports in oncology
ISSN: 1662-6575
Titre abrégé: Case Rep Oncol
Pays: Switzerland
ID NLM: 101517601
Informations de publication
Date de publication:
Historique:
received:
17
08
2020
accepted:
18
08
2020
entrez:
22
2
2021
pubmed:
23
2
2021
medline:
23
2
2021
Statut:
epublish
Résumé
Bladder tamponade due to hemorrhagic cystitis caused by BK virus in immunocompetent patients is familiar to urologists. BK virus is an important cause of nephropathy and graft loss in kidney transplant recipients. Although urothelial carcinoma of the bladder in kidney transplant recipients with persistent BK viruria is known, BK virus-associated urothelial carcinoma (BKVUC) in peripheral blood stem cell transplantation recipients is not as well known. A 54-year-old man with acute lymphoblastic leukemia was treated in the Department of Hematology of our hospital. After recurrence 25 months later, he received chemotherapy for half a year and underwent peripheral blood stem cell transplantation. He achieved temporarily complete remission, but he developed hematuria with BK virus-positive result 1 month after peripheral blood stem cell transplantation. One month later, he developed bladder tamponade-diagnosed hemorrhagic cystitis due to BK virus in our Urological Department. We performed transurethral coagulation to manage hemorrhage and removed a bleeding lesion in the bladder wall. Pathological examination of the removed bladder wall revealed pT1 stage BKVUC. We found that bladder tamponade could have led to reactivation of BK virus in this immunocompetent patient. This could be the first report of BKVUC of the bladder found in a peripheral blood stem cell transplantation recipient with close urological follow-up for 24 months. Adequate removal of bleeding lesions from the bladder mucosa with appropriate timing during hemorrhagic cystitis due to BKVUC could be essential to achieve good outcomes.
Identifiants
pubmed: 33613235
doi: 10.1159/000511053
pii: cro-0014-0008
pmc: PMC7879257
doi:
Types de publication
Case Reports
Langues
eng
Pagination
8-12Informations de copyright
Copyright © 2021 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest in association with this article.
Références
Pathol Res Pract. 2013 Apr;209(4):255-9
pubmed: 23481349
Hum Pathol. 2013 May;44(5):908-17
pubmed: 23317548
BJU Int. 2013 May;111(6):984-7
pubmed: 23351086
Diagn Cytopathol. 2006 Mar;34(3):201-3
pubmed: 16470860
Transpl Infect Dis. 2013 Jun;15(3):283-9
pubmed: 23551580
NDT Plus. 2009 Jun;2(3):246-9
pubmed: 25984002
Transplant Proc. 2009 Jan-Feb;41(1):165-6
pubmed: 19249504
Carcinogenesis. 2012 Apr;33(4):770-80
pubmed: 22287562
Int J Cancer. 2007 Mar 15;120(6):1248-51
pubmed: 17192899
Biol Blood Marrow Transplant. 2014 Apr;20(4):564-70
pubmed: 24462984
Blood. 2010 May 13;115(19):3861-8
pubmed: 20215642
Virology. 1995 Dec 1;214(1):273-9
pubmed: 8525628
Adv Exp Med Biol. 2006;577:19-45
pubmed: 16626025
Lancet. 1971 Jun 19;1(7712):1253-7
pubmed: 4104714
Bone Marrow Transplant. 2008 Apr;41(8):737-42
pubmed: 18176615