Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice.

cannabinoid receptor (CB1R) endocannabinoids leptin obesity orexin reward

Journal

Frontiers in synaptic neuroscience
ISSN: 1663-3563
Titre abrégé: Front Synaptic Neurosci
Pays: Switzerland
ID NLM: 101548972

Informations de publication

Date de publication:
2021
Historique:
received: 28 10 2020
accepted: 11 01 2021
entrez: 22 2 2021
pubmed: 23 2 2021
medline: 23 2 2021
Statut: epublish

Résumé

Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese

Identifiants

pubmed: 33613258
doi: 10.3389/fnsyn.2021.622405
pmc: PMC7890184
doi:

Types de publication

Journal Article

Langues

eng

Pagination

622405

Informations de copyright

Copyright © 2021 Tunisi, D'Angelo, Fernández-Rilo, Forte, Piscitelli, Imperatore, de Girolamo, Di Marzo and Cristino.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

J Comp Neurol. 2003 Oct 27;465(4):593-603
pubmed: 12975818
Nature. 2005 Sep 22;437(7058):556-9
pubmed: 16100511
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt B):132-142
pubmed: 28259721
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908200
Brain Res Brain Res Rev. 1993 Jan-Apr;18(1):75-113
pubmed: 8096779
Br J Pharmacol. 2015 Jan;172(2):334-48
pubmed: 24641197
Cell Metab. 2013 Apr 2;17(4):475-90
pubmed: 23562074
Mol Metab. 2017 Apr 22;6(6):594-601
pubmed: 28580289
Neuroscience. 2008 Oct 28;156(4):865-71
pubmed: 18790017
Neuropsychopharmacology. 2016 Jul;41(8):2101-11
pubmed: 26787120
Nat Neurosci. 2005 Nov;8(11):1442-4
pubmed: 16251985
CNS Drugs. 2016 May;30(5):369-79
pubmed: 27155860
Eur Arch Psychiatry Clin Neurosci. 2018 Apr;268(3):261-268
pubmed: 28364268
Front Endocrinol (Lausanne). 2019 Dec 10;10:830
pubmed: 31920958
J Neurosci. 2015 May 6;35(18):7295-303
pubmed: 25948277
Expert Opin Ther Targets. 2002 Oct;6(5):601-9
pubmed: 12387683
Pharmacol Res. 2016 Sep;111:600-609
pubmed: 27436148
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729
pubmed: 30348772
Neuropharmacology. 2008 Jan;54(1):95-107
pubmed: 17655884
J Physiol. 2020 Dec;598(23):5523-5539
pubmed: 32886798
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73
pubmed: 16357203
Eur J Nutr. 2016 Jun;55(4):1799-805
pubmed: 26759262
Psychopharmacology (Berl). 2014 Jan;231(2):419-27
pubmed: 23978908
Psychopharmacology (Berl). 2011 Mar;214(2):415-26
pubmed: 20959967
Cell Metab. 2009 Aug;10(2):89-98
pubmed: 19656487
J Neurosci. 2006 Jan 11;26(2):398-405
pubmed: 16407535
Arch Biochem Biophys. 2011 Apr 1;508(1):1-12
pubmed: 21176768
J Neurosci. 1984 Nov;4(11):2877-90
pubmed: 6150071
PLoS One. 2014 Jan 23;9(1):e87478
pubmed: 24466352
Trends Neurosci. 2000 Aug;23(8):359-65
pubmed: 10906799
Vitam Horm. 2012;89:185-208
pubmed: 22640614
Addict Biol. 2015 May;20(3):469-81
pubmed: 24712379
Neuroscience. 2010 Apr 28;167(1):11-20
pubmed: 20149847
Eur J Neurosci. 2008 Oct;28(8):1629-40
pubmed: 18973582
J Comp Neurol. 2001 Jun 18;435(1):6-25
pubmed: 11370008
J Mol Neurosci. 2011 Feb;43(2):217-24
pubmed: 21086064
Behav Brain Res. 2014 Oct 1;272:93-9
pubmed: 24983661
Sleep Med Rev. 2000 Feb;4(1):57-99
pubmed: 12531161
Nutr Rev. 2015 May;73(5):296-307
pubmed: 26011903
Neuron. 2006 Sep 21;51(6):811-22
pubmed: 16982425
PLoS One. 2010 Jul 09;5(7):e11503
pubmed: 20634890
Exp Neurobiol. 2018 Aug;27(4):309-319
pubmed: 30181693
J Neurosci. 2011 Oct 12;31(41):14600-10
pubmed: 21994376
Addict Biol. 2017 Nov;22(6):1695-1705
pubmed: 27480648
Psychopharmacology (Berl). 2018 Oct;235(10):3031-3043
pubmed: 30109373
Front Behav Neurosci. 2012 Nov 28;6:82
pubmed: 23226119
J Neurosci. 2004 Jan 7;24(1):53-62
pubmed: 14715937
Neuropsychopharmacology. 2016 Jan;41(2):508-20
pubmed: 26081302
Neuron. 2006 Feb 16;49(4):589-601
pubmed: 16476667
Brain Res. 1999 Mar 13;821(2):526-9
pubmed: 10064841
Neuropsychopharmacology. 2018 Jan;43(1):103-115
pubmed: 28653666
Neuroscience. 2002;111(2):379-87
pubmed: 11983323
Neuropsychopharmacology. 2012 Aug;37(9):1999-2011
pubmed: 22569505
Front Behav Neurosci. 2015 Dec 17;9:336
pubmed: 26733830
Cell Rep. 2017 Feb 7;18(6):1346-1355
pubmed: 28178514
Nat Commun. 2016 Jul 22;7:12199
pubmed: 27448020
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4759-64
pubmed: 27071101
Nat Neurosci. 2010 May;13(5):635-41
pubmed: 20348917
Cell. 2015 Jan 29;160(3):528-41
pubmed: 25635460
Peptides. 2005 Nov;26(11):2331-8
pubmed: 15893404
Brain Res. 2000 Aug 4;873(1):181-7
pubmed: 10915829
Neuroscience. 2012 May 17;210:243-8
pubmed: 22433299
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2229-38
pubmed: 23630288
Prog Neurobiol. 2002 Nov;68(4):247-86
pubmed: 12498988
Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R592-9
pubmed: 27385732

Auteurs

Lea Tunisi (L)

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.

Livia D'Angelo (L)

Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.

Alba Clara Fernández-Rilo (AC)

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.

Nicola Forte (N)

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Québec City, QC, Canada.

Fabiana Piscitelli (F)

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.

Roberta Imperatore (R)

Department of Sciences and Technologies, University of Sannio, Benevento, Italy.

Paolo de Girolamo (P)

Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.

Vincenzo Di Marzo (V)

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Québec City, QC, Canada.
Heart and Lung Research Institute of Université Laval, and Institute for Nutrition and Functional Foods, Université Laval, Québec City, QC, Canada.

Luigia Cristino (L)

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.

Classifications MeSH