Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm.

clazosentan endothelin pharmacodynamics pharmacokinetics subarachnoid hemorrhage–SAH

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2020
Historique:
received: 16 11 2020
accepted: 30 12 2020
entrez: 22 2 2021
pubmed: 23 2 2021
medline: 23 2 2021
Statut: epublish

Résumé

Aneurysmal subarachnoid hemorrhage (aSAH) may lead to cerebral vasospasm and is associated with significant morbidity and mortality. It represents a major unmet medical need due to few treatment options with limited efficacy. The role of endothelin-1 (ET-1) and its receptor ET

Identifiants

pubmed: 33613288
doi: 10.3389/fphar.2020.628956
pii: 628956
pmc: PMC7890197
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

628956

Informations de copyright

Copyright © 2021 Juif, Dingemanse and Ufer.

Déclaration de conflit d'intérêts

PJ, JD, and MU are employees of Idorsia Pharmaceuticals Ltd., the license holder of clazosentan and possess stock options/shares. The views expressed in this article are those of the authors and do not necessarily reflect those of their company.

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Auteurs

Pierre-Eric Juif (PE)

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland.

Jasper Dingemanse (J)

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland.

Mike Ufer (M)

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland.

Classifications MeSH