Gastrointestinal Helminth Infection Improves Insulin Sensitivity, Decreases Systemic Inflammation, and Alters the Composition of Gut Microbiota in Distinct Mouse Models of Type 2 Diabetes.
Animals
Blood Glucose
Body Weight
Diabetes Mellitus, Type 2
/ etiology
Diet, High-Fat
Eosinophils
Gastrointestinal Microbiome
Glucose Tolerance Test
Inflammation
/ prevention & control
Insulin Resistance
Leukocyte Count
Male
Metabolic Syndrome
/ therapy
Mice
Mice, Inbred C57BL
Nippostrongylus
Strongylida Infections
/ physiopathology
M2 macrophages
Nippostrongylus brasiliensis
eosinophils
helminth
high fat diet
high glycemic index diet
microbiota
type 2 diabetes
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
09
2020
accepted:
18
12
2020
entrez:
22
2
2021
pubmed:
23
2
2021
medline:
26
5
2021
Statut:
epublish
Résumé
Type 2 diabetes (T2D) is a major health problem and is considered one of the top 10 diseases leading to death globally. T2D has been widely associated with systemic and local inflammatory responses and with alterations in the gut microbiota. Microorganisms, including parasitic worms and gut microbes have exquisitely co-evolved with their hosts to establish an immunological interaction that is essential for the formation and maintenance of a balanced immune system, including suppression of excessive inflammation. Herein we show that both prophylactic and therapeutic infection of mice with the parasitic hookworm-like nematode,
Identifiants
pubmed: 33613446
doi: 10.3389/fendo.2020.606530
pmc: PMC7892786
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
606530Informations de copyright
Copyright © 2021 Khudhair, Alhallaf, Eichenberger, Whan, Kupz, Field, Krause, Wilson, Daly, Giacomin, Sotillo and Loukas.
Déclaration de conflit d'intérêts
Author LK was employed by company Microba Pty Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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