Recombinant immunotoxin targeting GPC3 is cytotoxic to H446 small cell lung cancer cells.
Wnt/β-catenin pathway
glypican-3
hepatocellular carcinoma
immunotherapy
immunotoxin
small cell lung carcinoma
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
23
07
2020
accepted:
09
12
2020
entrez:
22
2
2021
pubmed:
23
2
2021
medline:
23
2
2021
Statut:
ppublish
Résumé
Glypican-3 (GPC3) is a cell membrane glycoprotein that regulates cell growth and proliferation. Aberrant expression or distribution of GPC3 underlies developmental abnormalities and the development of solid tumours. The strongest evidence for the participation of GPC3 in carcinogenesis stems from studies on hepatocellular carcinoma and lung squamous cell carcinoma. To the best of our knowledge, the role of the GPC3 protein and its potential therapeutic application have never been studied in small cell lung carcinoma (SCLC), despite the known involvement of associated pathways and the high mortality caused by this disease. Therefore, the aim of the present study was to examine GPC3 targeting for SCLC immunotherapy. An immunotoxin carrying an anti-GPC3 antibody (hGC33) and
Identifiants
pubmed: 33613711
doi: 10.3892/ol.2021.12483
pii: OL-0-0-12483
pmc: PMC7859473
doi:
Types de publication
Journal Article
Langues
eng
Pagination
222Informations de copyright
Copyright: © Rodakowska et al.
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