Ablation of
ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 6
MATRIX MINERALIZATION
MATRIX VESICLE
ORPHAN PHOSPHATASE 1
OSTEOBLAST
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
03
06
2020
revised:
06
11
2020
accepted:
17
11
2020
entrez:
22
2
2021
pubmed:
23
2
2021
medline:
23
2
2021
Statut:
epublish
Résumé
Biomineralization is a fundamental process key to the development of the skeleton. The phosphatase orphan phosphatase 1 (PHOSPHO1), which likely functions within extracellular matrix vesicles, has emerged as a critical regulator of biomineralization. However, the biochemical pathways that generate intravesicular PHOSPHO1 substrates are currently unknown. We hypothesized that the enzyme ectonucleotide pyrophosphatase/phosphodiesterase 6 (ENPP6) is an upstream source of the PHOSPHO1 substrate. To test this, we characterized skeletal phenotypes of mice homozygous for a targeted deletion of
Identifiants
pubmed: 33615108
doi: 10.1002/jbm4.10439
pii: JBM410439
pmc: PMC7872340
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10439Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/R/00003741
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M021394/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
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