The corrected left ventricular ejection fraction: a potential new measure of ventricular function.
Amyloid
Cardiomyopathy
Ejection fraction
Hypertension
Left ventricular hypertrophy
Myocardial shortening
Myocardial strain
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
18
10
2020
accepted:
12
02
2021
pubmed:
23
2
2021
medline:
16
10
2021
entrez:
22
2
2021
Statut:
ppublish
Résumé
Left ventricular ejection fraction (LVEF) has a limited role in predicting outlook in heart diseases including heart failure. We quantified the independent geometric factors that determine LVEF using cardiac MRI and sought to provide an improved measure of ventricular function by adjusting for such independent variables. A mathematical model was used to analyse the independent effects of structural variables and myocardial shortening on LVEF. These results informed analysis of cardiac MRI data from 183 patients (53 idiopathic dilated cardiomyopathy (DCM), 36 amyloidosis, 55 hypertensives and 39 healthy controls). Left ventricular volumes, LVEF, wall thickness, internal dimensions and longitudinal and midwall fractional shortening were measured. The modelling demonstrated LVEF increased in a curvilinear manner with increasing mFS and longitudinal shortening and wall thickness but decreased with increasing internal diameter. Controls in the clinical cohort had a mean LVEF 64 ± 7%, hypertensives 66 ± 8%, amyloid 49 ± 16% and DCM 30 ± 11%. The mean end-diastolic wall thickness in controls was 8 ± 1 mm, DCM 8 ± 1 mm, hypertensives 11 ± 3 mm and amyloid 14 ± 3 mm, P < 0.0001). LVEF correlated with absolute wall thickening relative to ventricular size (R
Identifiants
pubmed: 33616783
doi: 10.1007/s10554-021-02193-4
pii: 10.1007/s10554-021-02193-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1987-1997Références
Volpi A, De Vita C, Franzosi MG, Geraci E, Maggioni AP, Mauri F et al (1993) Determinants of 6-month mortality in survivors of myocardial infarction after thrombolysis. Results of the GISSI-2 data base. The Ad hoc Working Group of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-2 Data Base. Circulation 88(2):416–429. https://doi.org/10.1161/01.cir.88.2.416
doi: 10.1161/01.cir.88.2.416
pubmed: 8339405
Lam CS, Donal E, Kraigher-Krainer E, Vasan RS (2011) Epidemiology and clinical course of heart failure with preserved ejection fraction. Eur J Heart Fail 13(1):18–28. https://doi.org/10.1093/eurjhf/hfq121
doi: 10.1093/eurjhf/hfq121
pubmed: 20685685
Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A et al (2006) Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 355(3):260–269. https://doi.org/10.1056/NEJMoa051530
doi: 10.1056/NEJMoa051530
pubmed: 16855266
Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3):251–259. https://doi.org/10.1056/NEJMoa052256
doi: 10.1056/NEJMoa052256
pubmed: 16855265
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ et al (2016) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European society of cardiology (ESC). Developed with the special contribution of the Heart failure association (HFA) of the ESC. Eur J Heart Fail 18(8):891–975. https://doi.org/10.1002/ejhf.592
doi: 10.1002/ejhf.592
Paulus WJ, Tschope C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers F et al (2007) How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the heart failure and echocardiography associations of the european society of cardiology. Eur Heart J 28:2539–2550
doi: 10.1093/eurheartj/ehm037
Kraigher-Krainer E, Shah AM, Gupta DK, Santos A, Claggett B, Pieske B et al (2014) Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. J Am Coll Cardiol 63(5):447–456. https://doi.org/10.1016/j.jacc.2013.09.052
doi: 10.1016/j.jacc.2013.09.052
pubmed: 24184245
Aurigemma GP, Gaasch WH, McLaughlin M, McGinn R, Sweeney A, Meyer TE (1995) Reduced left ventricular systolic pump performance and depressed myocardial contractile function in patients > 65 years of age with normal ejection fraction and a high relative wall thickness. Am J Cardiol 76(10):702–705. https://doi.org/10.1016/s0002-9149(99)80201-x
doi: 10.1016/s0002-9149(99)80201-x
pubmed: 7572629
Vinch CS, Aurigemma GP, Simon HU, Hill JC, Tighe DA, Meyer TE (2005) Analysis of left ventricular systolic function using midwall mechanics in patients > 60 years of age with hypertensive heart disease and heart failure. Am J Cardiol 96(9):1299–1303
doi: 10.1016/j.amjcard.2005.06.076
Koh YS, Jung HO, Park MW, Baek JY, Yoon SG, Kim PJ et al (2009) Comparison of left ventricular hypertrophy, fibrosis and dysfunction according to various disease mechanisms such as hypertension, diabetes mellitus and chronic renal failure. J Cardiovasc Ultrasound 17(4):127–134
doi: 10.4250/jcu.2009.17.4.127
Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP (1990) Prognostic implications of echocardiographically determined left ventricular mass in the framingham heart study. N Engl J Med 322(22):1561–1566. https://doi.org/10.1056/NEJM199005313222203
doi: 10.1056/NEJM199005313222203
pubmed: 2139921
Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH (1991) Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 114(5):345–352. https://doi.org/10.7326/0003-4819-114-5-345
doi: 10.7326/0003-4819-114-5-345
pubmed: 1825164
Maciver DH, Townsend M (2008) A novel mechanism of heart failure with normal ejection fraction. Heart 94(4):446–449. https://doi.org/10.1136/hrt.2006.114082
doi: 10.1136/hrt.2006.114082
pubmed: 17483129
Maciver DH (2011) A new method for quantification of left ventricular systolic function using a corrected ejection fraction. Eur J Echocardiogr 12(3):228–234. https://doi.org/10.1093/ejechocard/jeq185
doi: 10.1093/ejechocard/jeq185
pubmed: 21216767
Stokke TM, Hasselberg NE, Smedsrud MK, Sarvari SI, Haugaa KH, Smiseth OA et al (2017) Geometry as a confounder when assessing ventricular systolic function: comparison between ejection fraction and strain. J Am Coll Cardiol 70(8):942–954. https://doi.org/10.1016/j.jacc.2017.06.046
doi: 10.1016/j.jacc.2017.06.046
pubmed: 28818204
Pennell DJ (2002) Ventricular volume and mass by CMR. J Cardiovasc Magn Reson 4(4):507–513. https://doi.org/10.1081/jcmr-120016389
doi: 10.1081/jcmr-120016389
pubmed: 12549238
MacIver DH, Adeniran I, Zhang H (2015) Left ventricular ejection fraction is determined by both global myocardial strain and wall thickness. Int J Cardiol Heart Vasc 7:113–118. https://doi.org/10.1016/j.ijcha.2015.03.007
doi: 10.1016/j.ijcha.2015.03.007
pubmed: 28785658
pmcid: 5497228
Yin FC, Chan CC, Judd RM (1996) Compressibility of perfused passive myocardium. Am J Physiol 271(5 Pt 2):H1864–H1870. https://doi.org/10.1152/ajpheart.1996.271.5.H1864
doi: 10.1152/ajpheart.1996.271.5.H1864
pubmed: 8945902
Maciver DH (2012) The relative impact of circumferential and longitudinal shortening on left ventricular ejection fraction and stroke volume. Exp Clin Cardiol 17(1):5–11
pubmed: 23204893
pmcid: 3383360
Rodrigues JC, Rohan S, Dastidar AG, Trickey A, Szantho G, Ratcliffe LE et al (2016) The relationship between left ventricular wall thickness, myocardial shortening, and ejection fraction in hypertensive heart disease: insights from cardiac magnetic resonance imaging. J Clin Hypertens 18(11):1119–1127. https://doi.org/10.1111/jch.12849
doi: 10.1111/jch.12849
Maceira AM, Joshi J, Prasad SK, Moon JC, Perugini E, Harding I et al (2005) Cardiovascular magnetic resonance in cardiac amyloidosis. Circulation 111(2):186–193. https://doi.org/10.1161/01.CIR.0000152819.97857.9D
doi: 10.1161/01.CIR.0000152819.97857.9D
pubmed: 15630027
Pozo E, Kanwar A, Deochand R, Castellano JM, Naib T, Pazos-Lopez P et al (2014) Cardiac magnetic resonance evaluation of left ventricular remodelling distribution in cardiac amyloidosis. Heart 100(21):1688–1695. https://doi.org/10.1136/heartjnl-2014-305710
doi: 10.1136/heartjnl-2014-305710
pubmed: 25012950
Maceira AM, Prasad SK, Khan M, Pennell DJ (2006) Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 8(3):417–426. https://doi.org/10.1080/10976640600572889
doi: 10.1080/10976640600572889
pubmed: 16755827
Kawel N, Turkbey EB, Carr JJ, Eng J, Gomes AS, Hundley WG et al (2012) Normal left ventricular myocardial thickness for middle-aged and older subjects with steady-state free precession cardiac magnetic resonance: the multi-ethnic study of atherosclerosis. Circ Cardiovasc Imaging 5(4):500–508. https://doi.org/10.1161/CIRCIMAGING.112.973560
doi: 10.1161/CIRCIMAGING.112.973560
pubmed: 22705587
pmcid: 3412148
MacIver DH, Stephenson RS, Jensen B, Agger P, Sanchez-Quintana D, Jarvis JC et al (2018) The end of the unique myocardial band: Part I. Anatomical considerations. Eur J Cardiothorac Surg 53(1):112–119. https://doi.org/10.1093/ejcts/ezx290
doi: 10.1093/ejcts/ezx290
pubmed: 28958005
de Simone G, Devereux RB, Roman MJ, Ganau A, Saba PS, Alderman MH et al (1994) Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol 23(6):1444–1451. https://doi.org/10.1016/0735-1097(94)90390-5
doi: 10.1016/0735-1097(94)90390-5
pubmed: 8176105
de Simone G, Devereux RB (2002) Rationale of echocardiographic assessment of left ventricular wall stress and midwall mechanics in hypertensive heart disease. Eur J Echocardiogr 3(3):192–198. https://doi.org/10.1053/euje.2002.0163
doi: 10.1053/euje.2002.0163
pubmed: 12144838
Laskey WK, Alomari I, Cox M, Schulte PJ, Zhao X, Hernandez AF et al (2015) Heart rate at hospital discharge in patients with heart failure is associated with mortality and rehospitalization. J Am Heart Association 4(4):e001626
doi: 10.1161/JAHA.114.001626
Lam PH, Dooley DJ, Deedwania P, Singh SN, Bhatt DL, Morgan CJ et al (2017) Heart rate and outcomes in hospitalized patients with heart failure with preserved ejection fraction. J Am Coll Cardiol 70(15):1861–1871. https://doi.org/10.1016/j.jacc.2017.08.022
doi: 10.1016/j.jacc.2017.08.022
pubmed: 28982499
MacIver DH, Dayer MJ, Harrison AJ (2013) A general theory of acute and chronic heart failure. Int J Cardiol 165(1):25–34. https://doi.org/10.1016/j.ijcard.2012.03.093
doi: 10.1016/j.ijcard.2012.03.093
pubmed: 22483252
Forsythe L, MacIver DH, Johnson C, George K, Somauroo S, Papadakis M et al (2018) The relationship between left ventricular structure and function in the elite senior rugby football league athlete as determined by conventional 2D echocardiography and myocardial strain imaging. Int J Cardiol 261:211–217
doi: 10.1016/j.ijcard.2018.01.140
MacIver DH (2014) The impact of mitral regurgitation on left ventricular ejection fraction using mathematical modelling. Exp Clin Cardiol 20(9):4994–5008
Rodrigues JC, Dastidar AG, Paton JF, MacIver DH (2016) Precursors of hypertensive heart phenotype develop in healthy adults: an alternative explanation. JACC Cardiovasc Imaging 9(6):762–763. https://doi.org/10.1016/j.jcmg.2015.11.016
doi: 10.1016/j.jcmg.2015.11.016
pubmed: 26971001