Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis.
COVID-19
Diabetes mellitus
SARS-CoV-2
hospitalization
male
mortality
testosterone
Journal
Reviews in endocrine & metabolic disorders
ISSN: 1573-2606
Titre abrégé: Rev Endocr Metab Disord
Pays: Germany
ID NLM: 100940588
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
accepted:
20
01
2021
pubmed:
23
2
2021
medline:
12
5
2021
entrez:
22
2
2021
Statut:
ppublish
Résumé
The presence of SARS-CoV-2 was officially documented in Europe at the end of February 2020. Despite many observations, the real impact of COVID-19 in the European Union (EU), its underlying factors and their contribution to mortality and morbidity outcomes were never systematically investigated. The aim of the present work is to provide an overview and a meta-analysis of main predictors and of country differences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated mortality rate (MR) in hospitalized patients. Out of 3714 retrieved articles, 87 studies were considered, including 35,486 patients (mean age 60.9 ± 8.2 years) and 5867 deaths. After adjustment for confounders, diabetes mellitus was the best predictors of MR in an age- and sex-dependent manner, followed by chronic pulmonary obstructive diseases and malignancies. In both the US and Europe, MR was higher than that reported in Asia (25[20;29] % and 20[17;23] % vs. 13[10;17]%; both p < 0.02). Among clinical parameters, dyspnea, fatigue and myalgia, along with respiratory rate, emerged as the best predictors of MR. Finally, reduced lymphocyte and platelet count, along with increased D-dimer levels, all significantly contributed to increased mortality. The optimization of glucose profile along with an adequate thrombotic complications preventive strategy must become routine practice in diseased SARS-CoV-2 infected patients.
Identifiants
pubmed: 33616801
doi: 10.1007/s11154-021-09630-8
pii: 10.1007/s11154-021-09630-8
pmc: PMC7899074
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
275-296Références
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–62. https://doi.org/10.1016/s0140-6736(20)30566-3 .
doi: 10.1016/s0140-6736(20)30566-3
pubmed: 7270627
pmcid: 7270627
Corona G, Baldi E, Isidori AM, Paoli D, Pallotti F, De Santis L, et al. SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità). J Endocrinol Invest. 2020;43(8):1153–7. https://doi.org/10.1007/s40618-020-01290-w .
doi: 10.1007/s40618-020-01290-w
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet. 2020;395(10223):497–506. https://doi.org/10.1016/s0140-6736(20)30183-5 .
doi: 10.1016/s0140-6736(20)30183-5
pubmed: 31986264
Phelan AL, Katz R, Gostin LO. The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance. JAMA. 2020;323(8):709–10. https://doi.org/10.1001/jama.2020.1097 .
doi: 10.1001/jama.2020.1097
pubmed: 31999307
Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020:e3319. https://doi.org/10.1002/dmrr.3319 .
Zhu L, She ZG, Cheng X, Qin JJ, Zhang XJ, Cai J, et al. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020;31(6):1068-77.e3. https://doi.org/10.1016/j.cmet.2020.04.021 .
doi: 10.1016/j.cmet.2020.04.021
pubmed: 7252168
pmcid: 7252168
Erener S. Diabetes, infection risk and COVID-19. Mol Metab. 2020;39:101044. https://doi.org/10.1016/j.molmet.2020.101044 .
doi: 10.1016/j.molmet.2020.101044
pubmed: 32585364
pmcid: 7308743
Fleming N, Sacks LJ, Pham C, Neoh SL, Ekinci E. An overview of COVID-19 in people with diabetes pathophysiology and considerations in the inpatient setting. Diabet Med. 2020:e14509. https://doi.org/10.1111/dme.14509 .
Wang S, Ma P, Zhang S, Song S, Wang Z, Ma Y, et al. Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study. Diabetologia. 2020;63(10):2102–11. https://doi.org/10.1007/s00125-020-05209-1 .
doi: 10.1007/s00125-020-05209-1
pubmed: 32647915
Holman N, Knighton P, Kar P, O’Keefe J, Curley M, Weaver A, et al. Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study. Lancet Diabetes Endocrinol. 2020;8(10):823–33. https://doi.org/10.1016/s2213-8587(20)30271-0 .
doi: 10.1016/s2213-8587(20)30271-0
pubmed: 32798471
pmcid: 7426091
Loke YK, Golder SP, Vandenbroucke JP. Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources. Ther Adv Drug Saf. 2011;2(2):59–68. https://doi.org/10.1177/2042098611401129 .
doi: 10.1177/2042098611401129
pubmed: 25083202
pmcid: 4110807
Green MS, Swartz N, Nitzan D, Peer V. The male excess in case-fatality rates for COVID-19. A meta-analytic study of the age-related differences and consistency over six countries. medRxiv. 2020:2020.06.11.20128439. https://doi.org/10.1101/2020.06.11.20128439 .
Pivonello R AR, Pivonello C, Millar RP, Isidori AM, Corona G, Colao A. 2020 Sexual disparities in covid-19 outcome: are men weaker or women stronger? . Neroendocrinology. 2020;In press
Salonia A, Corona G, Giwercman A, Maggi M, Minhas S, Nappi RE, et al. SARS-CoV-2, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project. Andrology. 2020. https://doi.org/10.1111/andr.12811 .
doi: 10.1111/andr.12811
pubmed: 33275841
pmcid: 7280645
Rastrelli G, Di Stasi V, Inglese F, Beccaria M, Garuti M, Di Costanzo D, et al. Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. Andrology. 2020. https://doi.org/10.1111/andr.12821 .
doi: 10.1111/andr.12821
pubmed: 32436355
pmcid: 7280645
Çayan S, Uğuz M, Saylam B, Akbay E. Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease, 2019 (COVID-19) in SARS-CoV-2 infected male patients: a cohort study. Aging Male. 2020;1–11. https://doi.org/10.1080/13685538.2020.1807930 .
Maseroli E, Corona G, Rastrelli G, Lotti F, Cipriani S, Forti G, et al. Prevalence of endocrine and metabolic disorders in subjects with erectile dysfunction: a comparative study. J Sex Med. 2015;12(4):956–65. https://doi.org/10.1111/jsm.12832 .
doi: 10.1111/jsm.12832
pubmed: 25689116
Grossmann M, Ng Tang Fui M, Cheung AS. Late-onset hypogonadism: metabolic impact. Andrology. 2019. https://doi.org/10.1111/andr.12705 .
doi: 10.1111/andr.12705
pubmed: 31502758
Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab. 2011;96(8):2341–53. https://doi.org/10.1210/jc.2011-0118 .
doi: 10.1210/jc.2011-0118
pubmed: 21646372
Corona G, Mannucci E, Forti G, Maggi M. Following the common association between testosterone deficiency and diabetes mellitus, can testosterone be regarded as a new therapy for diabetes? Int J Androl. 2009;32(5):431–41. https://doi.org/10.1111/j.1365-2605.2009.00965.x .
doi: 10.1111/j.1365-2605.2009.00965.x
pubmed: 19538523
Corona G, Vignozzi L, Sforza A, Maggi M. Risks and benefits of late onset hypogonadism treatment: an expert opinion. World J Mens Health. 2013;31(2):103–25. https://doi.org/10.5534/wjmh.2013.31.2.103 .
doi: 10.5534/wjmh.2013.31.2.103
pubmed: 24044106
pmcid: 3770846
Corona G, Rastrelli G, Di Pasquale G, Sforza A, Mannucci E, Maggi M. Endogenous Testosterone Levels and Cardiovascular Risk: Meta-Analysis of Observational Studies. J Sex Med. 2018;15(9):1260–71. https://doi.org/10.1016/j.jsxm.2018.06.012 .
doi: 10.1016/j.jsxm.2018.06.012
pubmed: 30145097
Corona G, Maseroli E, Rastrelli G, Francomano D, Aversa A, Hackett GI, et al. Is late-onset hypogonadotropic hypogonadism a specific age-dependent disease, or merely an epiphenomenon caused by accumulating disease-burden? Minerva Endocrinol. 2016;41(2):196–210.
pubmed: 26883937
Turner HE, Wass JA. Gonadal function in men with chronic illness. Clin Endocrinol (Oxf). 1997;47(4):379–403. https://doi.org/10.1046/j.1365-2265.1997.2611108.x .
doi: 10.1046/j.1365-2265.1997.2611108.x
Shultz JM, Perlin A, Saltzman RG, Espinel Z, Galea S. Pandemic March: 2019 Coronavirus Disease's First Wave Circumnavigates the Globe. Disaster Med Public Health Prep. 2020:1-5. https://doi.org/10.1017/dmp.2020.103
Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol. 2020. https://doi.org/10.1002/jmv.26424 .
doi: 10.1002/jmv.26424
pubmed: 33289151
pmcid: 7753795
Wu X, Liu L, Jiao J, Yang L, Zhu B, Li X. Characterisation of clinical, laboratory and imaging factors related to mild vs. severe covid-19 infection: a systematic review and meta-analysis. Ann Med. 2020;52(7):334–44. https://doi.org/10.1080/07853890.2020.1802061 .
doi: 10.1080/07853890.2020.1802061
pubmed: 32755287
pmcid: 7877997
Qiu P, Zhou Y, Wang F, Wang H, Zhang M, Pan X, et al. Clinical characteristics, laboratory outcome characteristics, comorbidities, and complications of related COVID-19 deceased: a systematic review and meta-analysis. Aging Clin Exp Res. 2020;32(9):1869–78. https://doi.org/10.1007/s40520-020-01664-3 .
doi: 10.1007/s40520-020-01664-3
pubmed: 32734576
Fang X, Li S, Yu H, Wang P, Zhang Y, Chen Z, et al. Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis. Aging (Albany NY). 2020;12(13):12493–503. https://doi.org/10.18632/aging.103579 .
doi: 10.18632/aging.103579
Ahmed A, Ali A, Hasan S. Comparison of Epidemiological Variations in COVID-19 Patients Inside and Outside of China-A Meta-Analysis. Front Public Health. 2020;8:193. https://doi.org/10.3389/fpubh.2020.00193 .
doi: 10.3389/fpubh.2020.00193
pubmed: 32574293
pmcid: 7226658
Nasiri MJ, Haddadi S, Tahvildari A, Farsi Y, Arbabi M, Hasanzadeh S, et al. COVID-19 Clinical Characteristics, and Sex-Specific Risk of Mortality: Systematic Review and Meta-Analysis. Front Med (Lausanne). 2020;7:459. https://doi.org/10.3389/fmed.2020.00459 .
doi: 10.3389/fmed.2020.00459
Parohan M, Yaghoubi S, Seraji A, Javanbakht MH, Sarraf P, Djalali M. Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies. Aging Male. 2020:1-9. https://doi.org/10.1080/13685538.2020.1774748 .
Jutzeler CR, Bourguignon L, Weis CV, Tong B, Wong C, Rieck B, et al. Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;37:101825. https://doi.org/10.1016/j.tmaid.2020.101825 .
doi: 10.1016/j.tmaid.2020.101825
pubmed: 32763496
pmcid: 7402237
Ssentongo P, Ssentongo AE, Heilbrunn ES, Ba DM, Chinchilli VM. Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: A systematic review and meta-analysis. PLoS ONE. 2020;15(8):e0238215. https://doi.org/10.1371/journal.pone.0238215 .
doi: 10.1371/journal.pone.0238215
pubmed: 32845926
pmcid: 7449476
Abrishami A, Khalili N, Dalili N, Khaleghnejad Tabari R, Farjad R, Samavat S, et al. Clinical and Radiologic Characteristics of COVID-19 in Patients With CKD. Iran J Kidney Dis. 2020;14(4):267–77.
pubmed: 32655021
Aggarwal S, Garcia-Telles N, Aggarwal G, Lavie C, Lippi G, Henry BM. Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States. Diagnosis (Berl). 2020;7(2):91–6. https://doi.org/10.1515/dx-2020-0046 .
doi: 10.1515/dx-2020-0046
Alberici F, Delbarba E, Manenti C, Econimo L, Valerio F, Pola A, et al. A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia. Kidney Int. 2020;97(6):1083–8. https://doi.org/10.1016/j.kint.2020.04.002 .
doi: 10.1016/j.kint.2020.04.002
pubmed: 32354634
pmcid: 7142691
Argenziano MG, Bruce SL, Slater CL, Tiao JR, Baldwin MR, Barr RG, et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series. BMJ. 2020;369:m1996. https://doi.org/10.1136/bmj.m1996 .
doi: 10.1136/bmj.m1996
pubmed: 32471884
pmcid: 32471884
Arshad S, Kilgore P, Chaudhry ZS, Jacobsen G, Wang DD, Huitsing K, et al. Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19. Int J Infect Dis. 2020;97:396–403. https://doi.org/10.1016/j.ijid.2020.06.099 .
doi: 10.1016/j.ijid.2020.06.099
pubmed: 32623082
pmcid: 7330574
Bezzio C, Saibeni S, Variola A, Allocca M, Massari A, Gerardi V, et al. Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study. Gut. 2020;69(7):1213–7. https://doi.org/10.1136/gutjnl-2020-321411 .
doi: 10.1136/gutjnl-2020-321411
pubmed: 32354990
Borba MGS, Val FFA, Sampaio VS, Alexandre MAA, Melo GC, Brito M et al. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. JAMA Netw Open. 27020;3(4):e208857. https://doi.org/10.1001/jamanetworkopen.2020.8857 .
Burns GP, Lane ND, Tedd HM, Deutsch E, Douglas F, West SD et al. Improved survival following ward-based non-invasive pressure support for severe hypoxia in a cohort of frail patients with COVID-19: retrospective analysis from a UK teaching hospital. BMJ Open Respir Res. 2020;7(1). https://doi.org/10.1136/bmjresp-2020-000621 .
Campochiaro C, Della-Torre E, Cavalli G, De Luca G, Ripa M, Boffini N, et al. Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study. Eur J Intern Med. 2020;76:43–9. https://doi.org/10.1016/j.ejim.2020.05.021 .
doi: 10.1016/j.ejim.2020.05.021
pubmed: 32482597
pmcid: 7242960
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020;382(19):1787–99. https://doi.org/10.1056/NEJMoa2001282 .
doi: 10.1056/NEJMoa2001282
Capra R, De Rossi N, Mattioli F, Romanelli G, Scarpazza C, Sormani MP, et al. Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia. Eur J Intern Med. 2020;76:31–5. https://doi.org/10.1016/j.ejim.2020.05.009 .
doi: 10.1016/j.ejim.2020.05.009
pubmed: 32405160
pmcid: 7219361
Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829–38. https://doi.org/10.1016/j.kint.2020.03.005 .
doi: 10.1016/j.kint.2020.03.005
pubmed: 32247631
pmcid: 32247631
Chilimuri S, Sun H, Alemam A, Mantri N, Shehi E, Tejada J, et al. Predictors of Mortality in Adults Admitted with COVID-19: Retrospective Cohort Study from New York City. West J Emerg Med. 2020;21(4):779–84. https://doi.org/10.5811/westjem.2020.6.47919 .
doi: 10.5811/westjem.2020.6.47919
pubmed: 32726241
pmcid: 7390589
Chung SM, Lee YY, Ha E, Yoon JS, Won KC, Lee HW, et al. The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study. Diabetes Metab J. 2020;44(3):405–13. https://doi.org/10.4093/dmj.2020.0105 .
doi: 10.4093/dmj.2020.0105
pubmed: 32602272
pmcid: 7332325
Cui X, Yu X, Wu X, Huang L, Tian Y, Huang X, et al. Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study. Kidney Blood Press Res. 2020;45(4):612–22. https://doi.org/10.1159/000509517 .
doi: 10.1159/000509517
pubmed: 32712607
De Smet R, Mellaerts B, Vandewinckele H, Lybeert P, Frans E, Ombelet S et al. Frailty and Mortality in Hospitalized Older Adults With COVID-19: Retrospective Observational Study. J Am Med Dir Assoc. 2020;21(7):928–32 e1. https://doi.org/10.1016/j.jamda.2020.06.008 .
Du RH, Liang LR, Yang CQ, Wang W, Cao TZ, Li M et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. Eur Respir J. 2020;55(5). https://doi.org/10.1183/13993003.00524-2020 .
Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, et al. COVID-19 with Different Severities: A Multicenter Study of Clinical Features. Am J Respir Crit Care Med. 2020;201(11):1380–8. https://doi.org/10.1164/rccm.202002-0445OC .
doi: 10.1164/rccm.202002-0445OC
pubmed: 32275452
pmcid: 7258639
Gao L, Jiang D, Wen XS, Cheng XC, Sun M, He B, et al. Prognostic value of NT-proBNP in patients with severe COVID-19. Respir Res. 2020;21(1):83. https://doi.org/10.1186/s12931-020-01352-w .
doi: 10.1186/s12931-020-01352-w
pubmed: 32293449
pmcid: 7156898
Gregoriano C, Koch D, Haubitz S, Conen A, Fux CA, Mueller B, et al. Characteristics, predictors and outcomes among 99 patients hospitalised with COVID-19 in a tertiary care centre in Switzerland: an observational analysis. Swiss Med Wkly. 2020;150:w20316. https://doi.org/10.4414/smw.2020.20316 .
doi: 10.4414/smw.2020.20316
pubmed: 32668007
Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19. N Engl J Med. 2020;382(24):2327–36. https://doi.org/10.1056/NEJMoa2007016 .
doi: 10.1056/NEJMoa2007016
Hong KS, Lee KH, Chung JH, Shin KC, Choi EY, Jin HJ, et al. Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study. Yonsei Med J. 2020;61(5):431–7. https://doi.org/10.3349/ymj.2020.61.5.431 .
doi: 10.3349/ymj.2020.61.5.431
pubmed: 32390367
pmcid: 7214108
Huang M, Yang Y, Shang F, Zheng Y, Zhao W, Luo L, et al. Clinical Characteristics and Predictors of Disease Progression in Severe Patients with COVID-19 Infection in Jiangsu Province, China: A Descriptive Study. Am J Med Sci. 2020;360(2):120–8. https://doi.org/10.1016/j.amjms.2020.05.038 .
doi: 10.1016/j.amjms.2020.05.038
pubmed: 32709280
pmcid: 7837328
Inciardi RM, Adamo M, Lupi L, Cani DS, Di Pasquale M, Tomasoni D, et al. Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. Eur Heart J. 2020;41(19):1821–9. https://doi.org/10.1093/eurheartj/ehaa388 .
doi: 10.1093/eurheartj/ehaa388
pubmed: 32383763
pmcid: 7239204
Israelsen SB, Kristiansen KT, Hindsberger B, Ulrik CS, Andersen O, Jensen M et al. Characteristics of patients with COVID-19 pneumonia at Hvidovre Hospital, March-April 2020. Dan Med J. 2020;67(6).
Itelman E, Wasserstrum Y, Segev A, Avaky C, Negru L, Cohen D, et al. Clinical Characterization of 162 COVID-19 patients in Israel: Preliminary Report from a Large Tertiary Center. Isr Med Assoc J. 2020;22(5):271–4.
pubmed: 32378815
Jang JG, Hur J, Hong KS, Lee W, Ahn JH. Prognostic Accuracy of the SIRS, qSOFA, and NEWS for Early Detection of Clinical Deterioration in SARS-CoV-2 Infected Patients. J Korean Med Sci. 2020;35(25):e234. https://doi.org/10.3346/jkms.2020.35.e234 .
doi: 10.3346/jkms.2020.35.e234
pubmed: 32597046
pmcid: 7324266
Lagi F, Piccica M, Graziani L, Vellere I, Botta A, Tilli M et al. Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020. Euro Surveill. 2020;25(17). https://doi.org/10.2807/1560-7917.ES.2020.25.17.2000556 .
Lecronier M, Beurton A, Burrel S, Haudebourg L, Deleris R, Le Marec J, et al. Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis. Crit Care. 2020;24(1):418. https://doi.org/10.1186/s13054-020-03117-9 .
doi: 10.1186/s13054-020-03117-9
pubmed: 32653015
pmcid: 7351645
Lewnard JA, Liu VX, Jackson ML, Schmidt MA, Jewell BL, Flores JP, et al. Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study. BMJ. 2020;369:m1923. https://doi.org/10.1136/bmj.m1923 .
doi: 10.1136/bmj.m1923
pubmed: 32444358
pmcid: 7243800
Li L, Yang L, Gui S, Pan F, Ye T, Liang B, et al. Association of clinical and radiographic findings with the outcomes of 93 patients with COVID-19 in Wuhan. China Theranostics. 2020;10(14):6113–21. https://doi.org/10.7150/thno.46569 .
doi: 10.7150/thno.46569
pubmed: 32483442
Li R, Tian J, Yang F, Lv L, Yu J, Sun G, et al. Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan. China J Clin Virol. 2020;127:104363. https://doi.org/10.1016/j.jcv.2020.104363 .
doi: 10.1016/j.jcv.2020.104363
pubmed: 32298988
Li X, Guo Z, Li B, Zhang X, Tian R, Wu W, et al. Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019 in Shanghai. China ASAIO J. 2020;66(5):475–81. https://doi.org/10.1097/MAT.0000000000001172 .
doi: 10.1097/MAT.0000000000001172
pubmed: 32243266
Liu X, Zheng X, Liu B, Wu M, Zhang Z, Zhang G, et al. Serum IgM against SARS-CoV-2 correlates with in-hospital mortality in severe/critical patients with COVID-19 in Wuhan. China Aging (Albany NY). 2020;12(13):12432–40. https://doi.org/10.18632/aging.103417 .
doi: 10.18632/aging.103417
McMichael TM, Currie DW, Clark S, Pogosjans S, Kay M, Schwartz NG, et al. Epidemiology of Covid-19 in a Long-Term Care Facility in King County. Washington N Engl J Med. 2020;382(21):2005–11. https://doi.org/10.1056/NEJMoa2005412 .
doi: 10.1056/NEJMoa2005412
pubmed: 32220208
Meng Y, Wu P, Lu W, Liu K, Ma K, Huang L, et al. Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients. PLoS Pathog. 2020;16(4):e1008520. https://doi.org/10.1371/journal.ppat.1008520 .
doi: 10.1371/journal.ppat.1008520
pubmed: 32343745
pmcid: 7209966
Miyashita S, Yamada T, Mikami T, Miyashita H, Chopra N, Rizk D. Impact of dementia on clinical outcomes in elderly patients with coronavirus 2019 (COVID-19): an experience in New York. Geriatr Gerontol Int. 2020;20(7):732–4. https://doi.org/10.1111/ggi.13942 .
doi: 10.1111/ggi.13942
pubmed: 32691924
pmcid: 7404346
Moghaddam A, Heller RA, Sun Q, Seelig J, Cherkezov A, Seibert L et al. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients. 2020;12(7). https://doi.org/10.3390/nu12072098 .
Morena V, Milazzo L, Oreni L, Bestetti G, Fossali T, Bassoli C, et al. Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan. Italy Eur J Intern Med. 2020;76:36–42. https://doi.org/10.1016/j.ejim.2020.05.011 .
doi: 10.1016/j.ejim.2020.05.011
pubmed: 32448770
Myrstad M, Ihle-Hansen H, Tveita AA, Andersen EL, Nygard S, Tveit A, et al. National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study. Scand J Trauma Resusc Emerg Med. 2020;28(1):66. https://doi.org/10.1186/s13049-020-00764-3 .
doi: 10.1186/s13049-020-00764-3
pubmed: 32660623
pmcid: 7356106
Na KR, Kim HR, Ham Y, Choi DE, Lee KW, Moon JY, et al. Acute Kidney Injury and Kidney Damage in COVID-19 Patients. J Korean Med Sci. 2020;35(28):e257. https://doi.org/10.3346/jkms.2020.35.e257 .
doi: 10.3346/jkms.2020.35.e257
pubmed: 32686373
pmcid: 7371456
Nightingale R, Nwosu N, Kutubudin F, Fletcher T, Lewis J, Frost F et al. Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service. BMJ Open Respir Res. 2020;7(1). https://doi.org/10.1136/bmjresp-2020-000639 .
Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, et al. Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. J Clin Virol. 2020;127:104378. https://doi.org/10.1016/j.jcv.2020.104378 .
doi: 10.1016/j.jcv.2020.104378
pubmed: 32353762
pmcid: 7172806
Nowak B, Szymanski P, Pankowski I, Szarowska A, Zycinska K, Rogowski W, et al. Clinical characteristics and short-term outcomes of patients with coronavirus disease 2019: a retrospective single-center experience of a designated hospital in Poland. Pol Arch Intern Med. 2020;130(5):407–11. https://doi.org/10.20452/pamw.15361 .
doi: 10.20452/pamw.15361
pubmed: 32420710
Pan F, Zheng C, Ye T, Li L, Liu D, Li L, et al. Different computed tomography patterns of Coronavirus Disease 2019 (COVID-19) between survivors and non-survivors. Sci Rep. 2020;10(1):11336. https://doi.org/10.1038/s41598-020-68057-4 .
doi: 10.1038/s41598-020-68057-4
pubmed: 32647307
pmcid: 7347874
Pei G, Zhang Z, Peng J, Liu L, Zhang C, Yu C, et al. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol. 2020;31(6):1157–65. https://doi.org/10.1681/ASN.2020030276 .
doi: 10.1681/ASN.2020030276
pubmed: 32345702
pmcid: 32345702
Pellaud C, Grandmaison G, Pham Huu Thien HP, Baumberger M, Carrel G, Ksouri H et al. Characteristics, comorbidities, 30-day outcome and in-hospital mortality of patients hospitalised with COVID-19 in a Swiss area - a retrospective cohort study. Swiss Med Wkly. 2020;150:w20314. https://doi.org/10.4414/smw.2020.20314 .
Ren H, Yang Y, Wang F, Yan Y, Shi X, Dong K, et al. Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19. Cardiovasc Diabetol. 2020;19(1):58. https://doi.org/10.1186/s12933-020-01035-2 .
doi: 10.1186/s12933-020-01035-2
pubmed: 32393351
pmcid: 7213552
Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan. China Intensive Care Med. 2020;46(5):846–8. https://doi.org/10.1007/s00134-020-05991-x .
doi: 10.1007/s00134-020-05991-x
pubmed: 32125452
pmcid: 32125452
Satlin MJ, Goyal P, Magleby R, Maldarelli GA, Pham K, Kondo M, et al. Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease. PLoS ONE. 2020;15(7):e0236778. https://doi.org/10.1371/journal.pone.0236778 .
doi: 10.1371/journal.pone.0236778
pubmed: 32701969
pmcid: 7377460
Senkal N, Meral R, Medetalibeyoglu A, Konyaoglu H, Kose M, Tukek T. Association between chronic ACE inhibitor exposure and decreased odds of severe disease in patients with COVID-19. Anatol J Cardiol. 2020;24(1):21–9. https://doi.org/10.14744/AnatolJCardiol.2020.57431 .
doi: 10.14744/AnatolJCardiol.2020.57431
pubmed: 32628137
pmcid: 7414823
Shao F, Xu S, Ma X, Xu Z, Lyu J, Ng M, et al. In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan. China Resuscitation. 2020;151:18–23. https://doi.org/10.1016/j.resuscitation.2020.04.005 .
doi: 10.1016/j.resuscitation.2020.04.005
pubmed: 32283117
Shi Y, Yu X, Zhao H, Wang H, Zhao R, Sheng J. Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan. Crit Care. 2020;24(1):108. https://doi.org/10.1186/s13054-020-2833-7 .
doi: 10.1186/s13054-020-2833-7
pubmed: 32188484
pmcid: 32188484
Smith AA, Fridling J, Ibhrahim D, Porter PS Jr. Identifying Patients at Greatest Risk of Mortality due to COVID-19: A New England Perspective. West J Emerg Med. 2020;21(4):785–9. https://doi.org/10.5811/westjem.2020.6.47957 .
doi: 10.5811/westjem.2020.6.47957
pubmed: 32726242
pmcid: 7390549
Song JW, Zhang C, Fan X, Meng FP, Xu Z, Xia P, et al. Immunological and inflammatory profiles in mild and severe cases of COVID-19. Nat Commun. 2020;11(1):3410. https://doi.org/10.1038/s41467-020-17240-2 .
doi: 10.1038/s41467-020-17240-2
pubmed: 32641700
pmcid: 7343781
Steinberg E, Wright E, Kushner B. In Young Adults with COVID-19, Obesity Is Associated with Adverse Outcomes. West J Emerg Med. 2020;21(4):752–5. https://doi.org/10.5811/westjem.2020.5.47972 .
doi: 10.5811/westjem.2020.5.47972
pubmed: 32726235
pmcid: 7390557
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–7. https://doi.org/10.1111/jth.14768 .
doi: 10.1111/jth.14768
pubmed: 32073213
pmcid: 7166509
Tharakan S, Nomoto K, Miyashita S, Ishikawa K. Body temperature correlates with mortality in COVID-19 patients. Crit Care. 2020;24(1):298. https://doi.org/10.1186/s13054-020-03045-8 .
doi: 10.1186/s13054-020-03045-8
pubmed: 32503659
pmcid: 7274509
Trigo J, Garcia-Azorin D, Planchuelo-Gomez A, Martinez-Pias E, Talavera B, Hernandez-Perez I, et al. Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study. J Headache Pain. 2020;21(1):94. https://doi.org/10.1186/s10194-020-01165-8 .
doi: 10.1186/s10194-020-01165-8
pubmed: 32727345
pmcid: 7388434
Vuagnat P, Frelaut M, Ramtohul T, Basse C, Diakite S, Noret A, et al. COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Paris area. Breast Cancer Res. 2020;22(1):55. https://doi.org/10.1186/s13058-020-01293-8 .
doi: 10.1186/s13058-020-01293-8
pubmed: 32460829
pmcid: 7254663
Wang B, Van Oekelen O, Mouhieddine TH, Del Valle DM, Richter J, Cho HJ, et al. A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward. J Hematol Oncol. 2020;13(1):94. https://doi.org/10.1186/s13045-020-00934-x .
doi: 10.1186/s13045-020-00934-x
pubmed: 32664919
pmcid: 7359431
Wang L, He W, Yu X, Hu D, Bao M, Liu H, et al. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. J Infect. 2020;80(6):639–45. https://doi.org/10.1016/j.jinf.2020.03.019 .
doi: 10.1016/j.jinf.2020.03.019
pubmed: 32240670
pmcid: 7118526
Wang L, Li X, Chen H, Yan S, Li D, Li Y, et al. Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan. China Am J Nephrol. 2020;51(5):343–8. https://doi.org/10.1159/000507471 .
doi: 10.1159/000507471
pubmed: 32229732
Wang Y, Lu X, Li Y, Chen H, Chen T, Su N, et al. Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19. Am J Respir Crit Care Med. 2020;201(11):1430–4. https://doi.org/10.1164/rccm.202003-0736LE .
doi: 10.1164/rccm.202003-0736LE
pubmed: 32267160
pmcid: 7258632
Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, et al. Association Between Hypoxemia and Mortality in Patients With COVID-19. Mayo Clin Proc. 2020;95(6):1138–47. https://doi.org/10.1016/j.mayocp.2020.04.006 .
doi: 10.1016/j.mayocp.2020.04.006
pubmed: 32376101
pmcid: 7151468
Xu J, Yang X, Yang L, Zou X, Wang Y, Wu Y, et al. Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China. Crit Care. 2020;24(1):394. https://doi.org/10.1186/s13054-020-03098-9 .
doi: 10.1186/s13054-020-03098-9
pubmed: 32631393
pmcid: 7336107
Xu PP, Tian RH, Luo S, Zu ZY, Fan B, Wang XM, et al. Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study. Theranostics. 2020;10(14):6372–83. https://doi.org/10.7150/thno.46833 .
doi: 10.7150/thno.46833
pubmed: 32483458
pmcid: 7255028
Xu X, Han M, Li T, Sun W, Wang D, Fu B, et al. Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci U S A. 2020;117(20):10970–5. https://doi.org/10.1073/pnas.2005615117 .
doi: 10.1073/pnas.2005615117
pubmed: 7245089
pmcid: 7245089
Yan Y, Yang Y, Wang F, Ren H, Zhang S, Shi X et al. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. BMJ Open Diabetes Res Care. 2020;8(1). https://doi.org/10.1136/bmjdrc-2020-001343 .
Yang BY, Barnard LM, Emert JM, Drucker C, Schwarcz L, Counts CR, et al. Clinical Characteristics of Patients With Coronavirus Disease 2019 (COVID-19) Receiving Emergency Medical Services in King County, Washington. JAMA Netw Open. 2020;3(7):e2014549. https://doi.org/10.1001/jamanetworkopen.2020.14549 .
doi: 10.1001/jamanetworkopen.2020.14549
pubmed: 32639570
pmcid: 7344378
Yang Q, Zhou Y, Wang X, Gao S, Xiao Y, Zhang W, et al. Effect of hypertension on outcomes of adult inpatients with COVID-19 in Wuhan, China: a propensity score-matching analysis. Respir Res. 2020;21(1):172. https://doi.org/10.1186/s12931-020-01435-8 .
doi: 10.1186/s12931-020-01435-8
pubmed: 32631365
pmcid: 7336415
Yang X, Yang Q, Wang Y, Wu Y, Xu J, Yu Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020;18(6):1469–72. https://doi.org/10.1111/jth.14848 .
doi: 10.1111/jth.14848
pubmed: 32302435
Ye W, Chen G, Li X, Lan X, Ji C, Hou M, et al. Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19. Respir Res. 2020;21(1):169. https://doi.org/10.1186/s12931-020-01428-7 .
doi: 10.1186/s12931-020-01428-7
pubmed: 32620118
pmcid: 7332531
Yuan M, Yin W, Tao Z, Tan W, Hu Y. Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China. PLoS ONE. 2020;15(3):e0230548. https://doi.org/10.1371/journal.pone.0230548 .
doi: 10.1371/journal.pone.0230548
pubmed: 32191764
pmcid: 7082074
Zhang G, Hu C, Luo L, Fang F, Chen Y, Li J, et al. Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan. China J Clin Virol. 2020;127:104364. https://doi.org/10.1016/j.jcv.2020.104364 .
doi: 10.1016/j.jcv.2020.104364
pubmed: 32311650
Zhang J, Wang X, Jia X, Li J, Hu K, Chen G, et al. Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan. China Clin Microbiol Infect. 2020;26(6):767–72. https://doi.org/10.1016/j.cmi.2020.04.012 .
doi: 10.1016/j.cmi.2020.04.012
pubmed: 32304745
Zhang J, Meng G, Li W, Shi B, Dong H, Su Z, et al. Relationship of chest CT score with clinical characteristics of 108 patients hospitalized with COVID-19 in Wuhan, China. Respir Res. 2020;21(1):180. https://doi.org/10.1186/s12931-020-01440-x .
doi: 10.1186/s12931-020-01440-x
pubmed: 32664991
pmcid: 7359422
Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost. 2020;18(6):1324–9. https://doi.org/10.1111/jth.14859 .
doi: 10.1111/jth.14859
pubmed: 32306492
Zhang P, Zhu L, Cai J, Lei F, Qin JJ, Xie J, et al. Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19. Circ Res. 2020;126(12):1671–81. https://doi.org/10.1161/CIRCRESAHA.120.317134 .
doi: 10.1161/CIRCRESAHA.120.317134
pubmed: 32302265
pmcid: 7265882
Zhang S, Guo M, Duan L, Wu F, Hu G, Wang Z, et al. Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study. Crit Care. 2020;24(1):438. https://doi.org/10.1186/s13054-020-03123-x .
doi: 10.1186/s13054-020-03123-x
pubmed: 32678040
pmcid: 7364297
Zhang SY, Lian JS, Hu JH, Zhang XL, Lu YF, Cai H, et al. Clinical characteristics of different subtypes and risk factors for the severity of illness in patients with COVID-19 in Zhejiang, China. Infect Dis Poverty. 2020;9(1):85. https://doi.org/10.1186/s40249-020-00710-6 .
doi: 10.1186/s40249-020-00710-6
pubmed: 32641121
pmcid: 7341711
Zhao XY, Xu XX, Yin HS, Hu QM, Xiong T, Tang YY, et al. Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study. BMC Infect Dis. 2020;20(1):311. https://doi.org/10.1186/s12879-020-05010-w .
doi: 10.1186/s12879-020-05010-w
pubmed: 32345226
pmcid: 7188494
Zhu L, Gong N, Liu B, Lu X, Chen D, Chen S, et al. Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan. China Eur Urol. 2020;77(6):748–54. https://doi.org/10.1016/j.eururo.2020.03.039 .
doi: 10.1016/j.eururo.2020.03.039
pubmed: 32317180
Zou X, Li S, Fang M, Hu M, Bian Y, Ling J, et al. Acute Physiology and Chronic Health Evaluation II Score as a Predictor of Hospital Mortality in Patients of Coronavirus Disease 2019. Crit Care Med. 2020;48(8):e657–65. https://doi.org/10.1097/ccm.0000000000004411 .
doi: 10.1097/ccm.0000000000004411
pubmed: 32697506
pmcid: 7217128
Higgins JPT SJ, Savovi? J, Page MJ, Hróbjartsson A, Boutron I, Reeves B & Eldridge S. A revised tool for assessing risk of bias in randomized trials. Cochrane Database of Systematic Reviews. Cochrane Methods. 2016.
Begg CB, Mazumdar M. Operating Characteristics of a Rank Correlation Test for Publication Bias. Biometrics. 1994;50(4):1088–101. https://doi.org/10.2307/2533446 .
doi: 10.2307/2533446
pubmed: 7786990
Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P et al. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med. 2020:1–8. https://doi.org/10.1007/s42399-020-00363-4 .
Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. 2020;14(4):395–403. https://doi.org/10.1016/j.dsx.2020.04.018 .
doi: 10.1016/j.dsx.2020.04.018
pubmed: 32334395
pmcid: 7162793
Mantovani A, Byrne CD, Zheng MH, Targher G. Diabetes as a risk factor for greater COVID-19 severity and in-hospital death: A meta-analysis of observational studies. Nutr Metab Cardiovasc Dis. 2020;30(8):1236–48. https://doi.org/10.1016/j.numecd.2020.05.014 .
doi: 10.1016/j.numecd.2020.05.014
pubmed: 32571616
pmcid: 7258796
Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, et al. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020;63(8):1500–15. https://doi.org/10.1007/s00125-020-05180-x .
doi: 10.1007/s00125-020-05180-x
pubmed: 32472191
pmcid: 7256180
Booth CM, Matukas LM, Tomlinson GA, Rachlis AR, Rose DB, Dwosh HA, et al. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003;289(21):2801–9. https://doi.org/10.1001/jama.289.21.JOC30885 .
doi: 10.1001/jama.289.21.JOC30885
pubmed: 12734147
Alqahtani FY, Aleanizy FS, Ali El Hadi Mohamed R, Alanazi MS, Mohamed N, Alrasheed MM et al. Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study. Epidemiol Infect. 2018;147:1–5. https://doi.org/10.1017/s0950268818002923 .
Fuso L, Pitocco D, Antonelli-Incalzi R. Diabetic lung, an underrated complication from restrictive functional pattern to pulmonary hypertension. Diabetes Metab Res Rev. 2019;35(6):e3159. https://doi.org/10.1002/dmrr.3159 .
doi: 10.1002/dmrr.3159
pubmed: 30909316
Candido R, Jandeleit-Dahm KA, Cao Z, Nesteroff SP, Burns WC, Twigg SM, et al. Prevention of accelerated atherosclerosis by angiotensin-converting enzyme inhibition in diabetic apolipoprotein E-deficient mice. Circulation. 2002;106(2):246–53. https://doi.org/10.1161/01.cir.0000021122.63813.32 .
doi: 10.1161/01.cir.0000021122.63813.32
pubmed: 12105166
Bramante CT, Ingraham NE, Murray TA, Marmor S, Hovertsen S, Gronski J, et al. Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis. The Lancet Healthy Longevity. 2020. https://doi.org/10.1016/s2666-7568(20)30033-7 .
doi: 10.1016/s2666-7568(20)30033-7
pubmed: 33521772
pmcid: 7832552
Solerte SB, D’Addio F, Trevisan R, Lovati E, Rossi A, Pastore I, et al. Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective. Observational Study Diabetes Care. 2020;43(12):2999–3006. https://doi.org/10.2337/dc20-1521 .
doi: 10.2337/dc20-1521
pubmed: 32994187
Mirani M, Favacchio G, Carrone F, Betella N, Biamonte E, Morenghi E, et al. Impact of Comorbidities and Glycemia at Admission and Dipeptidyl Peptidase 4 Inhibitors in Patients With Type 2 Diabetes With COVID-19: A Case Series From an Academic Hospital in Lombardy. Italy Diabetes Care. 2020;43(12):3042–9. https://doi.org/10.2337/dc20-1340 .
doi: 10.2337/dc20-1340
pubmed: 33023989
Lampasona V, Secchi M, Scavini M, Bazzigaluppi E, Brigatti C, Marzinotto I, et al. Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study. Diabetologia. 2020;63(12):2548–58. https://doi.org/10.1007/s00125-020-05284-4 .
doi: 10.1007/s00125-020-05284-4
pubmed: 33029657
Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Lian N, et al. The impact of COPD and smoking history on the severity of COVID-19: A systemic review and meta-analysis. J Med Virol. 2020. https://doi.org/10.1002/jmv.25889 .
doi: 10.1002/jmv.25889
pubmed: 33289151
pmcid: 7537507
Zhang Y, Murugesan P, Huang K, Cai H. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Nat Rev Cardiol. 2020;17(3):170–94. https://doi.org/10.1038/s41569-019-0260-8 .
doi: 10.1038/s41569-019-0260-8
pubmed: 31591535
Davidson AM, Wysocki J, Batlle D. The interaction of SARS-CoV-2 and other coronavirus with Angiotensin Converting Enzyme 2 (ACE2) as their main receptor: therapeutic implications. Hypertension. 2020. https://doi.org/10.1161/hypertensionaha.120.15256 .
doi: 10.1161/hypertensionaha.120.15256
pubmed: 32851855
pmcid: 7480804
Pranata R, Permana H, Huang I, Lim MA, Soetedjo NNM, Supriyadi R, et al. The use of renin angiotensin system inhibitor on mortality in patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. Diabetes Metab Syndr. 2020;14(5):983–90. https://doi.org/10.1016/j.dsx.2020.06.047 .
doi: 10.1016/j.dsx.2020.06.047
pubmed: 32615377
pmcid: 7319940
Baral R, White M, Vassiliou VS. Effect of Renin-Angiotensin-Aldosterone System Inhibitors in Patients with COVID-19: a Systematic Review and Meta-analysis of 28,872 Patients. Curr Atheroscler Rep. 2020;22(10):61. https://doi.org/10.1007/s11883-020-00880-6 .
doi: 10.1007/s11883-020-00880-6
pubmed: 32830286
pmcid: 32830286
Boakye D, Rillmann B, Walter V, Jansen L, Hoffmeister M, Brenner H. Impact of comorbidity and frailty on prognosis in colorectal cancer patients: A systematic review and meta-analysis. Cancer Treat Rev. 2018;64:30–9. https://doi.org/10.1016/j.ctrv.2018.02.003 .
doi: 10.1016/j.ctrv.2018.02.003
pubmed: 29459248
Tönjes A, Hoffmann A, Kralisch S, Qureshi AR, Klöting N, Scholz M, et al. Pro-neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease. Eur J Endocrinol. 2020;183(3):233–44. https://doi.org/10.1530/eje-20-0087 .
doi: 10.1530/eje-20-0087
pubmed: 32508317
Qiu S, Cai X, Jia L, Sun Z, Wu T, Wendt J, et al. Does objectively-measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis. Eur Heart J Qual Care Clin Outcomes. 2020. https://doi.org/10.1093/ehjqcco/qcaa051 .
doi: 10.1093/ehjqcco/qcaa051
pubmed: 33351143
Galdas P, Cheater F, Marshall P. What is the role of masculinity in white and South Asian men’s decisions to seek medical help for cardiac chest pain? J Health Serv Res Policy. 2007;12(4):223–9. https://doi.org/10.1258/135581907782101552 .
doi: 10.1258/135581907782101552
pubmed: 17925074
Wambier CG, Goren A, Vaño-Galván S, Ramos PM, Ossimetha A, Nau G, et al. Androgen sensitivity gateway to COVID-19 disease severity. Drug Dev Res. 2020. https://doi.org/10.1002/ddr.21688 .
doi: 10.1002/ddr.21688
pubmed: 32412125
pmcid: 7273095
Asselta R, Paraboschi EM, Mantovani A, Duga S. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. Aging (Albany NY). 2020;12(11):10087–98. https://doi.org/10.18632/aging.103415 .
doi: 10.18632/aging.103415
Vom Steeg LG, Dhakal S, Woldetsadik YA, Park HS, Mulka KR, Reilly EC, et al. Androgen receptor signaling in the lungs mitigates inflammation and improves the outcome of influenza in mice. PLoS Pathog. 2020;16(7):e1008506. https://doi.org/10.1371/journal.ppat.1008506 .
doi: 10.1371/journal.ppat.1008506
Corona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, et al. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. Andrology. 2020;8(5):970–87. https://doi.org/10.1111/andr.12770 .
doi: 10.1111/andr.12770
pubmed: 32026626
Wittert G, Bracken K, Robledo KP, Grossmann M, Yeap BB, Handelsman DJ, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021;9(1):32–45. https://doi.org/10.1016/s2213-8587(20)30367-3 .
doi: 10.1016/s2213-8587(20)30367-3
pubmed: 33338415
Poissy J, Goutay J, Caplan M, Parmentier E, Duburcq T, Lassalle F, et al. Pulmonary Embolism in Patients With COVID-19: Awareness of an Increased Prevalence. Circulation. 2020;142(2):184–6. https://doi.org/10.1161/circulationaha.120.047430 .
doi: 10.1161/circulationaha.120.047430
pubmed: 32330083
Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res. 2020;191:148–50. https://doi.org/10.1016/j.thromres.2020.04.041 .
doi: 10.1016/j.thromres.2020.04.041
pubmed: 7192101
pmcid: 7192101
Grasselli G, Tonetti T, Protti A, Langer T, Girardis M, Bellani G, et al. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study. Lancet Respir Med. 2020. https://doi.org/10.1016/s2213-2600(20)30370-2 .
doi: 10.1016/s2213-2600(20)30370-2
pubmed: 33197387
pmcid: 7832136
Marietta M, Vandelli P, Mighali P, Vicini R, Coluccio V, D’Amico R. Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol. Trials. 2020;21(1):574. https://doi.org/10.1186/s13063-020-04475-z .
doi: 10.1186/s13063-020-04475-z
pubmed: 32586394
pmcid: 7316577
Mahumud RA, Kamara JK, Renzaho AMN. The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis. Infection. 2020:1–21. https://doi.org/10.1007/s15010-020-01502-8 .