Risk factors for vertical transmission of Chagas disease: A systematic review and meta-analysis.

Adult Chagas Disease / transmission Female Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical Parasite Load Pregnancy Pregnancy Complications, Parasitic Risk Factors
Chagas disease Meta-analysis Neonatal diseases Systematic review Vertical infection transmission

Journal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 10 01 2021
revised: 15 02 2021
accepted: 16 02 2021
pubmed: 23 2 2021
medline: 3 6 2021
entrez: 22 2 2021
Statut: ppublish

Résumé

Vertical transmission of Trypanosoma cruzi infection from mother to infant accounts for a growing proportion of new Chagas disease cases. However, no systematic reviews of risk factors for T. cruzi vertical transmission have been performed. We performed a systematic review of the literature in PubMed, LILACS, and Embase databases, following PRISMA guidelines. Studies were not excluded based on language, country of origin, or publication date. Our literature review yielded 27 relevant studies examining a wide variety of risk factors, including maternal age, parasitic load, immunologic factors and vector exposure. Several studies suggested that mothers with higher parasitic loads may have a greater risk of vertical transmission. A meta-analysis of 2 studies found a significantly higher parasitic load among transmitting than non-transmitting mothers with T. cruzi infection. A second meta-analysis of 10 studies demonstrated that maternal age was not significantly associated with vertical transmission risk. The literature suggests that high maternal parasitic load may be a risk factor for congenital Chagas disease among infants of T. cruzi seropositive mothers. Given the considerable heterogeneity and risk of bias among current literature, additional studies are warranted to assess potential risk factors for vertical transmission of T. cruzi infection.

Sections du résumé

BACKGROUND BACKGROUND
Vertical transmission of Trypanosoma cruzi infection from mother to infant accounts for a growing proportion of new Chagas disease cases. However, no systematic reviews of risk factors for T. cruzi vertical transmission have been performed.
METHODS METHODS
We performed a systematic review of the literature in PubMed, LILACS, and Embase databases, following PRISMA guidelines. Studies were not excluded based on language, country of origin, or publication date.
RESULTS RESULTS
Our literature review yielded 27 relevant studies examining a wide variety of risk factors, including maternal age, parasitic load, immunologic factors and vector exposure. Several studies suggested that mothers with higher parasitic loads may have a greater risk of vertical transmission. A meta-analysis of 2 studies found a significantly higher parasitic load among transmitting than non-transmitting mothers with T. cruzi infection. A second meta-analysis of 10 studies demonstrated that maternal age was not significantly associated with vertical transmission risk.
CONCLUSIONS CONCLUSIONS
The literature suggests that high maternal parasitic load may be a risk factor for congenital Chagas disease among infants of T. cruzi seropositive mothers. Given the considerable heterogeneity and risk of bias among current literature, additional studies are warranted to assess potential risk factors for vertical transmission of T. cruzi infection.

Identifiants

DOI: 10.1016/j.ijid.2021.02.074 PMID: 33618005 PMC: PMC8370023
pubmed: 33618005
pii: S1201-9712(21)00160-0
doi: 10.1016/j.ijid.2021.02.074
pmc: PMC8370023
mid: NIHMS1727177
pii:
doi:

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

357-373

Subventions

Organisme : FIC NIH HHS
ID : D43 TW010074
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI113197
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107028
Pays : United States

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Melissa D Klein (MD)

Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address: melissa_klein@med.unc.edu.

Alvaro Proaño (A)

Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.

Sassan Noazin (S)

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Michael Sciaudone (M)

Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Robert H Gilman (RH)

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Natalie M Bowman (NM)

Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address: natalie_bowman@med.unc.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Risk factors for vertical transmission of...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › Risk factors for vertical transmission of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Risk factors for vertical transmission of...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Risk factors for vertical transmission of...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Risk factors for vertical transmission of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Transmission de maladie infectieuse › Transmission verticale de maladie infectieuse › Risk factors for vertical transmission of...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Charge parasitaire › Risk factors for vertical transmission of...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Risk factors for vertical transmission of...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications infectieuses de la grossesse › Complications parasitaires de la grossesse › Risk factors for vertical transmission of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Risk factors for vertical transmission of...