Innate and Adaptive Immunity: ILC2 and Th2 Cells in Upper and Lower Airway Allergic Diseases.
Adaptive/acquired immunity
Allergic rhinitis
Asthma
Chronic rhinosinusitis with nasal polyps
Eosinophils
ILC2
Innate immunity
Th2
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
06
01
2021
revised:
05
02
2021
accepted:
09
02
2021
pubmed:
23
2
2021
medline:
25
5
2021
entrez:
22
2
2021
Statut:
ppublish
Résumé
Advances in our understanding of the immune system, with the recent discovery of a parallel set of innate T lymphocytes, the innate lymphocytes (ILCs), have led to a reassessment of the pathogenesis of allergic and eosinophilic airway disorders, including allergic rhinitis (AR), asthma, and chronic rhinosinusitis with nasal polyps. We review current understanding of both elements of type-2 inflammatory responses and their relative influence in these common conditions and consider possible impacts of this on treatment selection.
Identifiants
pubmed: 33618052
pii: S2213-2198(21)00193-8
doi: 10.1016/j.jaip.2021.02.013
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1851-1857Informations de copyright
Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.