Life-long brain compensatory responses to galactic cosmic radiation exposure.
Astronauts
Biomarkers
Brain
/ metabolism
Cosmic Radiation
/ adverse effects
Dentate Gyrus
/ metabolism
Environmental Exposure
/ adverse effects
Female
Hippocampus
/ metabolism
Humans
Male
Neurogenesis
/ radiation effects
Radiation Exposure
/ adverse effects
Space Flight
Spatial Learning
/ radiation effects
Time Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 02 2021
22 02 2021
Historique:
received:
05
10
2020
accepted:
01
02
2021
entrez:
23
2
2021
pubmed:
24
2
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Galactic cosmic radiation (GCR) composed of high-energy, heavy particles (HZE) poses potentially serious hazards to long-duration crewed missions in deep space beyond earth's magnetosphere, including planned missions to Mars. Chronic effects of GCR exposure on brain structure and cognitive function are poorly understood, thereby limiting risk reduction and mitigation strategies to protect against sequelae from exposure during and after deep-space travel. Given the selective vulnerability of the hippocampus to neurotoxic insult and the importance of this brain region to learning and memory, we hypothesized that GCR-relevant HZE exposure may induce long-term alterations in adult hippocampal neurogenesis, synaptic plasticity, and hippocampal-dependent learning and memory. To test this hypothesis, we irradiated 3-month-old male and female mice with a single, whole-body dose of 10, 50, or 100 cGy
Identifiants
pubmed: 33619310
doi: 10.1038/s41598-021-83447-y
pii: 10.1038/s41598-021-83447-y
pmc: PMC7900210
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
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