Estimating HIV incidence in the Akwa Ibom AIDS indicator survey (AKAIS), Nigeria using the limiting antigen avidity recency assay.
Adolescent
Adult
Anti-HIV Agents
/ therapeutic use
Antibody Affinity
/ immunology
Cross-Sectional Studies
Female
HIV Antibodies
/ blood
HIV Antigens
/ immunology
HIV Infections
/ diagnosis
HIV Seropositivity
/ blood
HIV-1
/ immunology
Humans
Immunoenzyme Techniques
/ methods
Incidence
Infant, Newborn
Male
Middle Aged
Nigeria
/ epidemiology
Surveys and Questionnaires
Viral Load
Young Adult
HIV-1
Nigeria
incidence
limiting antigen avidity
recent infection
viral load
Journal
Journal of the International AIDS Society
ISSN: 1758-2652
Titre abrégé: J Int AIDS Soc
Pays: Switzerland
ID NLM: 101478566
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
06
05
2020
revised:
31
12
2020
accepted:
13
01
2021
entrez:
23
2
2021
pubmed:
24
2
2021
medline:
18
9
2021
Statut:
ppublish
Résumé
HIV incidence estimates are important to characterize the status of an epidemic, identify locations and populations at high risk and to guide and evaluate HIV prevention interventions. We used the limiting antigen avidity assay (LAg) as part of a recent infection testing algorithm to estimate HIV incidence in the Akwa Ibom AIDS Indicator Survey (AKAIS), Nigeria. In 2017, AKAIS, a cross-sectional population-based study was conducted at the household (HH) level in 31 local government areas (LGAs) of Akwa Ibom state. Of the 8963 participants aged ≥15 years who were administered questionnaires for demographic and behavioural data, 8306 consented to HIV rapid testing. Whole-blood specimens were collected from 394 preliminary HIV-seropositive individuals for CD4+ cell count determination and plasma storage. Samples were shipped to a central quality laboratory for HIV confirmatory testing and viral load determination. A total of 370 HIV-positive specimens were tested for the recent HIV infection using the LAg assay. Of the 8306 consenting adults, the HIV prevalence was 4.8%. Of the 370 HIV-positive samples tested for HIV recency, the median age was 35 years, 48.8% had CD4+ cell count >500/mm The finding of the high HIV incidence among the 15 to 49-year age group calls for renewed and innovative efforts to prevent HIV infection among young adults in Akwa Ibom state.
Identifiants
pubmed: 33619853
doi: 10.1002/jia2.25669
pmc: PMC7900440
doi:
Substances chimiques
Anti-HIV Agents
0
HIV Antibodies
0
HIV Antigens
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25669Subventions
Organisme : PEPFAR
Pays : United States
Informations de copyright
© 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.
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