How Do Electrostatic Perturbations of the Protein Affect the Bifurcation Pathways of Substrate Hydroxylation versus Desaturation in the Nonheme Iron-Dependent Viomycin Biosynthesis Enzyme?

Bacterial Proteins / chemistry Catalytic Domain Hydroxylation Iron / metabolism Models, Molecular Nonheme Iron Proteins / chemistry Oxygenases / chemistry Static Electricity Viomycin / biosynthesis

Journal

The journal of physical chemistry. A
ISSN: 1520-5215
Titre abrégé: J Phys Chem A
Pays: United States
ID NLM: 9890903

Informations de publication

Date de publication:
04 Mar 2021
Historique:
pubmed: 24 2 2021
medline: 2 7 2021
entrez: 23 2 2021
Statut: ppublish

Résumé

The viomycin biosynthesis enzyme VioC is a nonheme iron and α-ketoglutarate-dependent dioxygenase involved in the selective hydroxylation of l-arginine at the C

Identifiants

DOI: 10.1021/acs.jpca.1c00141 PMID: 33620220
pubmed: 33620220
doi: 10.1021/acs.jpca.1c00141
doi:

Substances chimiques

Bacterial Proteins 0
Nonheme Iron Proteins 0
Iron E1UOL152H7
Oxygenases EC 1.13.-
vioC protein, Chromobacterium violaceum EC 1.13.-
Viomycin YVU35998K5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1720-1737

Auteurs

Hafiz Saqib Ali (HS)

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.
ORCID: 0000-0001-5770-5376

Richard H Henchman (RH)

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.
ORCID: 0000-0002-0461-6625

Jim Warwicker (J)

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

Sam P de Visser (SP)

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.
ORCID: 0000-0002-2620-8788

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Métabolisme › Hydroxylation › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électricité › Électricité statique › How Do Electrostatic Perturbations of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Viomycine › How Do Electrostatic Perturbations of the...